Results 81 to 90 of about 11,998,196 (407)
Future of smart cardiovascular implants [PDF]
, 2018 Cardiovascular disease remains the leading cause of death in Western society. Recent technological advances have opened the opportunity of developing new and innovative smart stent devices that have advanced electrical properties that can improve ...
Bussooa, Anubhav +2 more
core +1 more source
Molecular Oncology, EarlyView.In thyroid cancer patients, high‐dose (≥7.4 GBq) radioactive iodine therapy (RAIT) was associated with a higher prevalence of clonal hematopoiesis (variant allele frequency >2%) in individuals aged ≥50 years (OR = 2.44). In silico analyses showed that truncating PPM1D mutations conferred a selective advantage under these conditions.
Jaeryuk Kim +11 more
wiley +1 more source
Patient and Disease-Specific Induced Pluripotent Stem Cells for Discovery of Personalized Cardiovascular Drugs and Therapeutics. [PDF]
, 2020 Human induced pluripotent stem cells (iPSCs) have emerged as an effective platform for regenerative therapy, disease modeling, and drug discovery.
Chandy, Mark +2 more
core
Current trends in single‐cell RNA sequencing applications in diabetes mellitus
FEBS Open Bio, EarlyView.Single‐cell RNA sequencing is a powerful approach to decipher the cellular and molecular landscape at a single‐cell resolution. The rapid development of this technology has led to a wide range of applications, including the detection of cellular and molecular mechanisms and the identification and introduction of novel potential diagnostic and ...
Seyed Sajjad Zadian +6 more
wiley +1 more source
Small Molecules Enable Cardiac Reprogramming of Mouse Fibroblasts with a Single Factor, Oct4
Cell Reports, 2014 It was recently shown that mouse fibroblasts could be reprogrammed into cells of a cardiac fate by forced expression of multiple transcription factors and microRNAs.
Haixia Wang +9 more
doaj +1 more source
Pulmonary vasodilators: beyond the bounds of pulmonary arterial hypertension therapy in COVID-19
Pulmonary Circulation, 2020 Pulmonary arterial hypertension (PAH) and novel coronavirus (SARS-CoV-2) disease COVID-19 are characterized by extensive endothelial dysfunction and inflammation leading to vascular remodeling and severe microthrombi and microvascular obliterative ...
Veronica Franco +8 more
doaj +1 more source
Lipoprotein(a) Reduction in Persons with Cardiovascular Disease.
New England Journal of Medicine, 2020 BACKGROUND Lipoprotein(a) levels are genetically determined and, when elevated, are a risk factor for cardiovascular disease and aortic stenosis. There are no approved pharmacologic therapies to lower lipoprotein(a) levels.
S. Tsimikas +14 more
semanticscholar +1 more source
Cardiovascular disease in the elderly
Current Problems in Cardiology, 1987 The current worldwide explosive increase in the numbers of older persons is unprecedented in history. In the 1990s and beyond, the preponderance of patients with cardiovascular illness will be elderly, with a substantial subset among the frail elderly, 85 years old and older.
openaire +6 more sources
MicroRNA and Cardiovascular Disease [PDF]
BioMed Research International, 2015 Cardiovascular disease (CVD) is the leading cause of death and a major financial burden in most developed countries around the world, resulting in an estimated death toll of 17 million people in 2011. During the past decade, there have been significant advances in our knowledge of the pathogenesis, diagnosis, and treatment in CVD.
Xiao-Bo Liao +4 more
openaire +2 more sources
FEBS Open Bio, EarlyView.Cleavable N‐terminal Thioredoxin fusion enabled soluble expression and purification of otherwise insoluble SARS‐CoV‐2 Nucleocapsid (N) protein. A four‐step purification strategy yielded highly homogeneous, RNA‐free N protein. Binding assays showed high RNA affinity (Kd ~ 28 nm). The study will facilitate high‐resolution structural studies of N protein,
Shweta Singh, Gagan D. Gupta
wiley +1 more source