Results 51 to 60 of about 1,188,706 (294)

Formation of calcium phosphate bions in patients with carotid and coronary atherosclerosis

Российский кардиологический журнал, 2020
Aim. To study the formation of calcium phosphate bions (CPB), a trigger of endothelial dysfunction in the patients with coronary and carotid atherosclerosis as compared to healthy blood donors.Material and methods.
A. G. Kutikhin, D. K. Shishkova, O. N. Khryachkova, A. V. Frolov, N. Yu. Osyaev, E. V. Indukaeva, O. V. Gruzdeva, A. R. Shabaev, N. I. Zagorodnikov, V. E. Markova, L. А. Bogdanov   +10 more
doaj   +1 more source

Gut alterations in a chronic kidney disease rat model with diet‐induced vascular calcification

FEBS Open Bio, EarlyView.
Chronic kidney disease (CKD) patients often suffer from intestinal and/or mineral and bone disorders. Using a rat model, we showed that uremic vascular calcification is associated with gut barrier alterations (decreased gut mucus production and Nlrp6 gene expression, increased gut inflammation), and plasma retention of gut‐origin uremic toxins (indoxyl
Piotr Bartochowski, Irene Cortijo, Shruti Bhargava, Bernard Jover, Fabrice Raynaud, Juliana H Boukhaled, Anne‐Dominique Lajoix, Vera Jankowski, Joachim Jankowski, Magali Cordaillat‐Simmons, Àngel Argilés, Nathalie Gayrard, Flore Duranton, Jonas Laget   +13 more
wiley   +1 more source

Iron‐dependent lysosomal LDL oxidation induces the expression of scavenger receptor A in human THP‐1 monocytes

FEBS Open Bio, EarlyView.
In human monocytic cells THP‐1, a limited uptake of native—not oxidized—LDL/VLDL induced expression of scavenger receptor A and cellular adhesion. Induction was inhibited by lysosomotropic (WR‐1065) and lipophilic (BHT) antioxidants and by siRNAs against ferritinophagy.
Martina Čierna, Richard Buchal, Martin Leníček, Amit Shachak, Jan Pláteník   +4 more
wiley   +1 more source

Vascular endothelial growth factor improves physico-mechanical properties and enhances endothelialization of poly(3-hydroxybutyrate-co-3-hydroxyvalerate)/poly(ε-caprolactone) small-diameter vascular grafts in vivo

Frontiers in Pharmacology, 2016
The combination of a natural hydrophilic polymer poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) and a synthetic hydrophobic polymer poly(ε-caprolactone) (PCL) is promising for the preparation of biodegradable and biocompatible small-diameter ...
Larisa V Antonova, Victoria V Sevostyanova, Anton G Kutikhin, Andrey V Mironov, Evgeniya O Krivkina, Amin R Shabaev, Vera G Matveeva, Elena A Velikanova, Evgeniya A Sergeeva, Andrey Yu Burago, Georgiy Yu Vasyukov, Tatiana V Glushkova, Yuliya A Kudryavtseva, Olga L Barbarash, Leonid S Barbarash   +14 more
doaj   +1 more source

Current trends in single‐cell RNA sequencing applications in diabetes mellitus

FEBS Open Bio, EarlyView.
Single‐cell RNA sequencing is a powerful approach to decipher the cellular and molecular landscape at a single‐cell resolution. The rapid development of this technology has led to a wide range of applications, including the detection of cellular and molecular mechanisms and the identification and introduction of novel potential diagnostic and ...
Seyed Sajjad Zadian, Khodakaram Jahanbin, Shekoofeh Nikooei, Marzieh Rostaminejad, Arezoo Rahimi, Pedram Abdizadeh, Behnam Alipoor   +6 more
wiley   +1 more source

Integrative Single-Cell Analysis of Cardiomyopathy Identifies Differences in Cell Stemness and Transcriptional Regulatory Networks among Fibroblast Subpopulations

Cardiology Research and Practice
Background. Cardiomyopathy encompasses a broad spectrum of diseases affecting myocardial tissue, characterized clinically by abnormalities in cardiac structure, heart failure, and/or arrhythmias.
Wenyang Nie, Zhijie Zhao, Yuhang Liu, Youcao Wang, Jingwen Zhang, Ying Hu, Yang Liu, Yong Wang, Zhen Wang   +8 more
doaj   +1 more source

Six-months success of radiofrequency ablation in cardiac arrhythmias treatment: Experience of our centre [PDF]

Vojnosanitetski Pregled, 2019
Background/Aim. Numerous trials have shown a high success of radiofrequency ablation (RFA) in the treatment of the patients with cardiac arrhythmias. We aimed to examine the RFA initial success in treatment of different cardiac arrhythmias and the RFA ...
Jurčević-Mudrić Ružica, Angelkov Lazar, Tomović Milosav, Kojić Dejan, Milojević Predrag   +4 more
doaj   +1 more source

Microbiome and Cardiovascular Disease [PDF]

, 2020
AbstractAtherosclerotic cardiovascular disease (ASCVD) is a prime example of a systems disease. In the initial phase, apolipoprotein B-containing cholesterol-rich lipoproteins deposit excess cholesterol in macrophage-like cells that subsequently develop into foam cells.
Herrema, Hilde, Nieuwdorp, Max, Groen, Albert K.   +2 more
openaire   +5 more sources

An efficient strategy for producing RNA‐free Nucleocapsid protein of SARS‐CoV‐2 for biochemical and structural investigations

FEBS Open Bio, EarlyView.
Cleavable N‐terminal Thioredoxin fusion enabled soluble expression and purification of otherwise insoluble SARS‐CoV‐2 Nucleocapsid (N) protein. A four‐step purification strategy yielded highly homogeneous, RNA‐free N protein. Binding assays showed high RNA affinity (Kd ~ 28 nm). The study will facilitate high‐resolution structural studies of N protein,
Shweta Singh, Gagan D. Gupta
wiley   +1 more source

Diastolic Pulmonary Gradient as a Predictor of Right Ventricular Failure After Left Ventricular Assist Device Implantation

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2019
Background Diastolic pulmonary gradient (DPG) was proposed as a better marker of pulmonary vascular remodeling compared with pulmonary vascular resistance (PVR) and transpulmonary gradient (TPG). The prognostic significance of DPG in patients requiring a
Hilmi Alnsasra, Rabea Asleh, Sarah D. Schettle, Naveen L. Pereira, Robert P. Frantz, Brooks S. Edwards, Alfredo L. Clavell, Simon Maltais, Richard C. Daly, John M. Stulak, Andrew N. Rosenbaum, Atta Behfar, Sudhir S. Kushwaha   +12 more
doaj   +1 more source