Results 51 to 60 of about 1,387,753 (249)

SIRT4 positively regulates autophagy via ULK1, but independently of HDAC6 and OPA1

FEBS Open Bio, EarlyView.
Cells expressing SIRT4 (H161Y), a catalytically inactive mutant of the sirtuin SIRT4, fail to upregulate LC3B‐II and exhibit a reduced autophagic flux under stress conditions. Interestingly, SIRT4(H161Y) promotes phosphorylation of ULK1 at S638 and S758 that are associated with inhibition of autophagy initiation.
Isabell Lehmkuhl, Khawar Amin, Lydia Gabriel, Nils Hampel, Afshin Iram, Julia Hesse, Constanze Wiek, Jasmin Thuy Vy Nguyen, Helmut Hanenberg, Jürgen Scheller, M. Reza Ahmadian, Björn Stork, Doreen M. Floss, Roland P. Piekorz   +13 more
wiley   +1 more source

Interpretation of the Annual Report on Cardiovascular Health and Diseases in China 2021

Cardiology Discovery, 2023
The Writing Committee of the Annual Report on Cardiovascular Health and Diseases in China
doaj   +1 more source

Ten years risk assessment of atherosclerotic cardiovascular disease using Astro-CHARM and pooled cohort equation in a south Asian sub-population

BMC Public Health, 2020
Background Atherosclerotic cardiovascular diseases (ASCVD) are on the rise in low and middle-income countries attributed to modern sedentary lifestyle and dietary habits.
Tariq Ashraf, Muhammad Naeem Mengal, Atif Sher Muhammad, Asal Khan Tareen, Muhammad Nauman Khan, Khawar Abbas Kazmi, Asif Nadeem, Shakil Sarwar, Zara Bashir, Nadeem Qamar, Musa Karim   +10 more
doaj   +1 more source

Optimal LDL cholesterol levels in young and old patients with type 2 diabetes for secondary prevention of cardiovascular diseases are different [PDF]

, 2023
Chaiho Jeong, Bongseong Kim, Jinyoung Kim, Han-Sang Baek, Mee Kyoung Kim, Tae Seo Sohn, Ki‐Hyun Baek, Ki‐Ho Song, Hyun-Shik Son, Kyungdo Han, Hyuk‐Sang Kwon   +10 more
openalex   +1 more source

Evaluation of in vitro toxicity of common phytochemicals included in weight loss supplements using 1H NMR spectroscopy

FEBS Open Bio, EarlyView.
We investigated the toxicity of 12 active compounds commonly found in herbal weight loss supplements (WLS) using human liver and colon cell models. Epigallocatechin‐3‐gallate was the only compound showing significant toxicity. Metabolic profiling revealed protein degradation, disrupted energy and lipid metabolism suggesting that the inclusion of EGCG ...
Emily C. Davies, Garth L. Maker, Ian F. Musgrave, Samantha Lodge   +3 more
wiley   +1 more source

Interpretation of Annual Report on Cardiovascular Health and Diseases in China 2019

Cardiology Discovery, 2021
The Writing Committee of the Annual Report on Cardiovascular Health and Diseases in China, Xiaoxia Fu, Tianyu Xu   +2 more
doaj   +1 more source

Burden of cardiovascular disease in women: data from Pakistan’s largest cardiac hospital network

npj Women's Health
Cardiovascular disease (CVD) is understudied, underdiagnosed, and undertreated in women due to a lack of knowledge and understanding, particularly in the context of low-middle incomes countries (LMICs).
Sabha Bhatti, Samir Rehman, Sidra Fayyaz, Sumyia Gurmani, Musa Karim, Tahir Saghir, Abdul Hakeem   +6 more
doaj   +1 more source

Assessment of the prognostic performance of TIMI, PAMI, CADILLAC and GRACE scores for short-term major adverse cardiovascular events in patients undergoing emergent percutaneous revascularisation: a prospective observational study

BMJ Open
Objectives Accurately predicting short-term MACE (major adverse cardiac events) following primary percutaneous coronary intervention (PCI) remains a clinical challenge.
Rajesh Kumar, Shaheer Khan, Jawaid Akbar Sial, Musa Karim, Tahir Saghir, Uroosa Safdar, Nasir Yaqoob, Sumaira Fareed Khan, Khairaj Matani, Naveedullah Khan, Bisma Jalil, Elham Yousufzai, Muhammad Owais Shahid, Shitba Naeem, Kanchan Bhagia, Moiz Ahmed, Abdul Fatah Tunio, Kainat Arif Mughal, Ali Hyder, Fawad Farooq   +19 more
doaj   +1 more source

Understanding bio‐based polymers: A study of origins, properties, biodegradation and their impact on health and the environment

FEBS Open Bio, EarlyView.
This review provides an overview of bio‐based polymer sources, their unique functional properties and their environmental impact, and addresses their role as sustainable alternatives. It discusses end‐of‐life options, including composting and anaerobic digestion for renewable energy.
Sabina Kolbl Repinc, Blaž Stres, Mirica Karlovits, Igor Karlovits, Petra Jerič, Ondrej Panák, Anja Verbič, Blaž Likozar, Uroš Novak   +8 more
wiley   +1 more source

Do collaterals to infarct bed in STE-ACS patients undergoing emergent percutaneous coronary revascularization matter? An assessment of a prospective pool for in-hospital course

Indian Heart Journal
Background: Limited data exist on the role of coronary collaterals circulation (CCC) in patients with ST-elevation acute coronary syndrome (STE-ACS).
Rajesh Kumar, Naveed Ullah Khan, Ayaz Mir, Khalid Naseeb, Gulzar Ali, Arti Ashok, Mukesh Kumar, Abiha Urooj, Uroosa Safdar, Aisha Hussain, Muhammad Ishaq, Tahir Saghir, Jawaid Akbar Sial, Abdul Hakeem, Musa Karim   +14 more
doaj   +1 more source