Results 61 to 70 of about 11,050,255 (347)

The zinc finger domains of PARP‐1 are selectively and potently inhibited by the Au(I)‐based drugs sodium aurothiomalate and aurothioglucose

FEBS Letters, EarlyView.
PARP‐1 is a key enzyme in the DNA damage response, and its inhibition induces cancer cell death via synthetic lethality. Au(I)‐based drugs, such as aurothioglucose and sodium aurothiomalate, block PARP‐1's DNA‐dependent activity by targeting its zinc finger domains.
Uliana Bashtanova, Melinda Jane Duer
wiley   +1 more source

Results of preclinical trials in a sheep model of biodegradable small-diameter vascular grafts

Вестник трансплантологии и искусственных органов, 2022
Surface modification of polymer vascular matrices is a promising development for preventing vascular graft thrombosis, improving long-term patency and accelerating remodeling. Objective: to study the outcomes of long-term patency of PHBV/PCL/GFmix grafts
L. V. Antonova, E. O. Krivkina, M. Yu. Khanova, E. A. Velikanova, V. G. Matveeva, А. V. Mironov, A. R. Shabaev, Е. A. Senokosova, T. V. Glushkova, M. Yu. Sinitsky, R. А. Mukhamadiyarov, L. S. Barbarash   +11 more
doaj   +1 more source

COPD and Cardiovascular Disease

Pulmonology, 2019
COPD is one of the major public health problems in people aged 40 years or above. It is currently the 4th leading cause of death in the world and projected to be the 3rd leading cause of death by 2020. COPD and cardiac comorbidities are frequently associated.
André, S., Conde, B., Fragoso, E., Boléo-Tomé, J.P., Areias, Vanda, Cardoso, J.   +5 more
openaire   +6 more sources

European Code Against Cancer, 5th edition – hormone replacement therapy, other common medical therapies and cancer

Molecular Oncology, EarlyView.
The 5th edition of the European Code Against Cancer (ECAC5) contains 14 recommendations on cancer prevention. Here, we update the cancer prevention recommendations regarding the use of hormone replacement therapy (HRT), which is positioned as recommendation number 13 of the ECAC5.
Mangesh A. Thorat, Marc Arbyn, David Baldwin, Xavier Castells, Solveig Hofvind, Urska Ivanus, Carlo Senore, Esther Toes‐Zoutendijk, Carlijn van der Aalst, Carlos Canelo‐Aybar, Fiorella Karina Fernández‐Sáenz, Ariadna Feliu, Hajo Zeeb, Andre L. Carvalho, Erica D'Souza, David Ritchie, Carolina Espina, Iris Lansdorp‐Vogelaar, Andrea DeCensi   +18 more
wiley   +1 more source

Predictors of myocardial fibrosis and loss of epicardial adipose tissue volume in the long-term period after myocardial infarction

Российский кардиологический журнал, 2020
Aim. To assess the changes of biochemical markers in hospitalization, the relationship with the severity of myocardial fibrosis and the epicardial adipose tissue (EAT) thickness one year after myocardial infarction (MI).Material and methods.
O. L. Barbarash, O. V. Gruzdeva, T. B. Pecherina, O. E. Akbasheva, D. A. Borodkina, V. V. Kashtalap, V. N. Karetnikova, A. N. Kokov, N. K. Brel, Yu. A. Dyleva, E. V. Belik, E. G. Uchasova, E. E. Bychkova, A. A. Kuzmina   +13 more
doaj   +1 more source

Experience in the development of a system for repeated prosthetic heart valves

Сибирский научный медицинский журнал, 2023
The failure of heart valve bioprostheses, requiring repeated intervention to replace them, is a serious drawback that narrows the scope of such devices.
E. A. Ovcharenko, K. Yu. Klyshnikov, A. N. Stasev, A. V. Evtushenko, I. K. Khalivopulo, D. V. Borisenko, T. V. Glushkova, A. V. Ivanova, I. V. Dvadtsatov, S. S. Krutitsky, Yu. A. Kudryavtseva, O. L. Barbarash, L. S. Barbarash   +12 more
doaj   +1 more source

Genetic Testing for Inherited Cardiovascular Diseases: A Scientific Statement From the American Heart Association.

Circulation Genomic and Precision Medicine, 2020
Advances in human genetics are improving the understanding of a variety of inherited cardiovascular diseases, including cardiomyopathies, arrhythmic disorders, vascular disorders, and lipid disorders such as familial hypercholesterolemia.
K. Musunuru, R. Hershberger, S. Day, N. J. Klinedinst, A. Landstrom, V. Parikh, Siddharth K. Prakash, C. Semsarian, A. Sturm   +8 more
semanticscholar   +1 more source

Depression and Cardiovascular Diseases

Annals of the Russian academy of medical sciences, 2014
Depression is considered to be an independent cardiovascular risk factor and it may worsen the symptoms of already established cardiovascular pathology such as coronary heart disease, chronic heart failure, stroke and hypertension. 3 key psychobiological mechanisms by means of which depression influences cardiovascular system: disbalance in stress ...
N F, Nuralieva, D A, Napalkov
openaire   +3 more sources

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Low-Dose Gallic Acid Administration Does Not Improve Diet-Induced Metabolic Disorders and Atherosclerosis in Apoe Knockout Mice

Journal of Immunology Research, 2022
Diets rich in polyphenols are known to be beneficial for cardiovascular health. Gallic acid (GA) is a plant-derived triphenolic chemical with multiple cardio-protective properties, such as antiobesity, anti-inflammation, and antioxidation.
Jie Bai, Qiu-Yue Lin, Xiangbo An, Shuang Liu, Yao Wang, Yunpeng Xie, Jiawei Liao   +6 more
doaj   +1 more source