Results 71 to 80 of about 11,050,255 (347)

Berberine–cinnamic acid co‐crystal effect in ameliorating hyperlipidemia might be regulated through the PI3K/AKT/mTOR/SREBP‐1 signaling pathway

FEBS Open Bio, EarlyView.
Berberine–cinnamic acid co‐crystal (BBR‐CA) inhibits the phosphorylation of the phosphatidylinositol 3‐kinase (PI3K)/AKT/mammalian target of rapamycin (mTOR) pathway, suppressing the transfer of pre‐sterol regulatory element‐binding proteins‐1 (SREBP‐1) from the endoplasmic reticulum to the nucleus. This results in a decrease in the expression level of
Wenheng Gao, Yunlong Li, Lihua Chen, Wenshuo Yang, Yong He, Ye Yang, Dengke Yin, Song Tan   +7 more
wiley   +1 more source

Menopause and cardiovascular disease

Journal of Mid-life Health, 2019
Menopausal health demand priority in Indian scenario due to increase in life expectancy and growing population of menopausal women. Time demands to promote a multidisciplinary, multi-factorial, comprehensive approach to the care of these women. By the medium of this editorial and our experience in dealing women in advancing age in and around menopause,
Annil Mahajan, Ranu Patni, Varun Gupta
openaire   +3 more sources

The impact of Hnrnpl deficiency on transcriptional patterns of developing muscle cells

FEBS Open Bio, EarlyView.
We performed nanopore whole‐transcriptome sequencing comparing RNA from Hnrnpl‐knockdown versus control C2C12 myoblasts to investigate the contributions of Hnrnpl to muscle development. Our results indicate that Hnrnpl regulates the expression of genes involved with Notch signaling and skeletal muscle, particularly splicing patterns of specific muscle ...
Hannah R. Littel, Mekala Gunasekaran, Audrey L. Daugherty, Natalya M. Wells, Johnnie Turner, Christine C. Bruels, Christina A. Pacak, Isabelle Draper, Peter B. Kang   +8 more
wiley   +1 more source

Predictors and Clinical Outcomes of Vasoplegia in Patients Bridged to Heart Transplantation With Continuous‐Flow Left Ventricular Assist Devices

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2019
Background The presence of a durable left ventricular assist device (LVAD) is associated with increased risk of vasoplegia in the early postoperative period following heart transplantation (HT).
Rabea Asleh, Hilmi Alnsasra, Richard C. Daly, Sarah D. Schettle, Alexandros Briasoulis, Riad Taher, Shannon M. Dunlay, John M. Stulak, Atta Behfar, Naveen L. Pereira, Robert P. Frantz, Brooks S. Edwards, Alfredo L. Clavell, Sudhir S. Kushwaha   +13 more
doaj   +1 more source

Short‐term actions of epigalocatechin‐3‐gallate in the liver: a mechanistic insight into hypoglycemic and potential toxic effects

FEBS Open Bio, EarlyView.
Epigallocatechin‐3‐gallate (EGCG) acutely inhibited gluconeogenesis and enhanced glycolysis, glycogenolysis, and fatty acid oxidation in perfused rat livers. Mechanistic assays revealed mitochondrial uncoupling, inhibition of pyruvate carboxylation and glucose‐6‐phosphatase, shift of NADH/NAD+ ratios toward oxidation, and loss of membrane integrity ...
Carla Indianara Bonetti, Bruna Lopes Correia, Francielle Cristina Nakamura Manicardi, Nairana Mithieli de Queiroz Eskuarek Melo, Vanesa de Oliveira Pateis, Jurandir Fernando Comar, Anacharis Babeto de Sá‐Nakanishi, Adelar Bracht, Lívia Bracht   +8 more
wiley   +1 more source

Predictive accuracy of systolic blood pressure to left ventricular end-diastolic pressure ratio versus TIMI score for short-term mortality after primary percutaneous coronary intervention [PDF]

Journal of Cardiovascular and Thoracic Research
Introduction: Aim of this study was to evaluate the predictive performance of systolic blood pressure (SBP) to left ventricular end-diastolic pressure (LVEDP) ratio for the prediction of in-hospital and short-term mortality in a contemporary cohort of ...
Rajesh Kumar, Naveed Ullah Khan, Ali Bin Naseer, Zille Huma, Kalsoom Chachar, Maryam Samad, Muhammad Ishaq, Abiha Urooj, Uroosa Safdar, Muhammad Rasool, Sohail Khan, Jawaid Akbar Sial, Tahir Saghir, Nadeem Qamar   +13 more
doaj   +1 more source

The role of mitochondrial dynamics in cardiovascular diseases

British Journal of Pharmacology, 2020
The process of mitochondrial dynamics is emerging as a core player in cardiovascular homeostasis. This process refers to the co‐ordinated cycles of biogenesis, fusion, fission and degradation to which mitochondria constantly undergo to maintain their ...
Maurizio Forte, L. Schirone, P. Ameri, C. Basso, D. Catalucci, Jessica Modica, C. Chimenti, L. Crotti, G. Frati, S. Rubattu, G. Schiattarella, D. Torella, C. Perrino, C. Indolfi, S. Sciarretta   +14 more
semanticscholar   +1 more source

The Emerging Role of Irisin in Cardiovascular Diseases

Journal of the American Heart Association : Cardiovascular and Cerebrovascular Disease, 2021
Irisin, a novel hormone like polypeptide, is cleaved and secreted by an unknown protease from a membrane‐spanning protein, FNDC5 (fibronectin type III domain‐containing protein 5).
Jinjuan Fu, Fangtang Li, Yuanjuan Tang, Lin Cai, C. Zeng, Yongjian Yang, Jian Yang   +6 more
semanticscholar   +1 more source

HSP70 governs permeability and mechanotransduction in primary human endothelial cells

FEBS Open Bio, EarlyView.
HSP70 chemical inhibition reduces endothelial cell proliferation and increases permeability, the latter supported by normal interendothelial junctional protein distribution. HSP70 also plays a role in shear stress response, a hemodynamic force naturally present in blood vessels and correlated with vessel protection.
Andrea Pinto‐Martinez, Everton G. Melo, Isadora C. B. Pavan, Percíllia V. S. Oliveira, Luiza B. C. T. Coimbra, Thaís L. S. Araujo   +5 more
wiley   +1 more source

Radial or femoral access in primary percutaneous coronary intervention (PCI): Does the choice matters?

Indian Heart Journal, 2020
Background: This study was conducted with the aim of providing a quantitative appraisal of clinical outcomes of trans-radial access for primary percutaneous coronary interventions (PCI) in patients with ST-segment evaluation myocardial infarction (STEMI).
Mahesh Kumar Batra, Lajpat Rai, Naveed Ullah Khan, Muhammad Naeem Mengal, Sanam Khowaja, Syed Nadeem Hassan Rizvi, Tahir Saghir, Nadeem Qamar, Jawaid Akbar Sial, Musa Karim   +9 more
doaj   +1 more source