Results 71 to 80 of about 1,188,706 (294)

The Comparative Effectiveness and Tolerability of Sphingosine‐1‐Phosphate Receptor Modulators in Patients With Multiple Sclerosis: A Network Meta‐Analysis of Randomized Controlled Trials

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Sphingosine‐1‐phosphate receptor modulators (S1PRM) are used to treat relapsing multiple sclerosis (MS). Each drug has a different S1PR‐subtype selectivity. They target the G‐protein coupled S1P receptors and exert significant immunomodulatory effects, such as preventing the formation of new CNS lesions and the reactivation of pre ...
Faizan Shahzad, Taimoon Rasheed, Momina Riaz Siddiqui, Hamza Hamid, Marwah Bintay Khalid, Haroon Shabbir, Besher Shami, Abdullah, Syed Ijlal Ahmed   +8 more
wiley   +1 more source

Burden of cardiovascular disease in women: data from Pakistan’s largest cardiac hospital network

npj Women's Health
Cardiovascular disease (CVD) is understudied, underdiagnosed, and undertreated in women due to a lack of knowledge and understanding, particularly in the context of low-middle incomes countries (LMICs).
Sabha Bhatti, Samir Rehman, Sidra Fayyaz, Sumyia Gurmani, Musa Karim, Tahir Saghir, Abdul Hakeem   +6 more
doaj   +1 more source

Metabolic Consequences of Rheumatoid Arthritis

Arthritis Care &Research, EarlyView.
Patients with rheumatoid arthritis (RA) may have metabolic disruption, which can contribute to adverse long‐term outcomes, for multiple reasons. Patients with RA appear to have a higher risk of sarcopenia, type 1 and type 2 diabetes mellitus, metabolic syndrome, and hypertension. Systemic inflammation in RA can cause a “lipid paradox,” with reduced low‐
Stevie Barry, Emily Sheng, Joshua F. Baker   +2 more
wiley   +1 more source

Assessment of the prognostic performance of TIMI, PAMI, CADILLAC and GRACE scores for short-term major adverse cardiovascular events in patients undergoing emergent percutaneous revascularisation: a prospective observational study

BMJ Open
Objectives Accurately predicting short-term MACE (major adverse cardiac events) following primary percutaneous coronary intervention (PCI) remains a clinical challenge.
Rajesh Kumar, Shaheer Khan, Jawaid Akbar Sial, Musa Karim, Tahir Saghir, Uroosa Safdar, Nasir Yaqoob, Sumaira Fareed Khan, Khairaj Matani, Naveedullah Khan, Bisma Jalil, Elham Yousufzai, Muhammad Owais Shahid, Shitba Naeem, Kanchan Bhagia, Moiz Ahmed, Abdul Fatah Tunio, Kainat Arif Mughal, Ali Hyder, Fawad Farooq   +19 more
doaj   +1 more source

Topological Data Analysis Identified Prognostically-Distinct Phenotypes in Transcatheter Edge-to-Edge Repair Patients

Mayo Clinic Proceedings: Digital Health, 2023
Objective: To identify prognostically distinct phenotype clusters in transcatheter edge-to-edge repair (TEER) patients based on topological data analysis (TDA), which was never used to assess the heterogeneous TEER population.
Chieh-Ju Chao, MD, Timothy Barry, MB, BCh, BAO, Amith Seri, MBBS, Ahmed El Shaer, MBBS, Nadia Chavez Ponce, MD, Soham Chakraborty, BS, Sean Smith, MD, Mohamad Alkhouli, MD, Jeremy Thaden, MD, David Fortuin, MD, John P. Sweeney, MD, Mackram Eleid, MD, Charanjit S. Rihal, MD, David R. Holmes, MD, Peter M. Pollak, MD, Abdallah El Sabbagh, MD, Steven J. Lester, MD, Jae K. Oh, MD, Win-Kuang Shen, MD, Imon Banerjee, PhD, Reza Arsanjani, MD   +20 more
doaj  

Periodontal disease and cardiovascular disease [PDF]

Evidence-Based Dentistry, 2004
Data sources Medline (1980–present) and bibliographic citations from each article were consulted to find relevant studies. Study selection Analyses were restricted to cohort studies published between 1980 and February 2001 so that any effects of secular trends could be minimised.
openaire   +4 more sources

Association of Higher Levels of High‐Sensitivity C‐Reactive Protein With Future Development of Psoriatic Arthritis in Psoriasis: A Prospective Cohort Study

Arthritis Care &Research, EarlyView.
Objective We aimed to assess whether high‐sensitivity C‐reactive protein (hsCRP) levels could predict the development of psoriatic arthritis (PsA) in patients with psoriasis. Methods We analyzed data from a prospective cohort of patients with psoriasis without PsA at enrollment.
Lihi Eder, Xianwei Li, Vinod Chandran, Cheryl F. Rosen, Richard J. Cook, Dafna D. Gladman   +5 more
wiley   +1 more source

Biologics and Cardiovascular Disease

Journal of Cardiovascular Pharmacology, 2018
Abstract: The advent of biologic therapy has enhanced our ability to augment disease in an increasingly targeted manner. The use of biologics in cardiovascular disease (CVD) has steadily increased over the past several decades. Much of the early data on biologics and CVD were derived from their use in rheumatologic populations ...
Juan C. Frías, Michael J. Lipinski, John S Van Taunay, M. Teresa Albelda   +3 more
openaire   +3 more sources

Avoidable Hospitalizations in Persons With Rheumatoid Arthritis: A Population‐Based Study Using Administrative Data

Arthritis Care &Research, EarlyView.
Objective We estimated incidence rates of avoidable hospitalizations by persons with rheumatoid arthritis (RA) relative to the general population. Methods We identified individuals meeting a validated case definition for RA based on International Classification of Diseases, Ninth Revision, Clinical Modification (ICD‐9‐CM) and ICD‐10‐CA codes in years ...
Dani G. Contreras, Claire E. H. Barber, J. Antonio Aviña‐Zubieta, Hude Quan, Seungwon Lee, James A. King, Cheryl Barnabe   +6 more
wiley   +1 more source

Xenoantigenicity of porcine decellularized valves

Journal of Cardiothoracic Surgery, 2017
Background The xenoantigenicity of porcine bioprosthetic valves is implicated as an etiology leading to calcification and subsequent valve failure. Decellularization of porcine valves theoretically could erase the antigenicity of the tissue leading to ...
Meghana R. K. Helder, Nicholas J. Stoyles, Brandon J. Tefft, Ryan S. Hennessy, Rebecca R. C. Hennessy, Roy Dyer, Tyra Witt, Robert D. Simari, Amir Lerman   +8 more
doaj   +1 more source