Results 61 to 70 of about 2,278,438 (306)

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Sauna use as a novel management approach for cardiovascular health and peripheral arterial disease

Frontiers in Cardiovascular Medicine
IntroductionHeat therapy (HT), particularly in the form of whole-body sauna bathing, has emerged as a promising intervention for the management of cardiovascular disease (CVD).
Sergio Sastriques-Dunlop, Santiago Elizondo-Benedetto, Mohamed A. Zayed, Mohamed A. Zayed, Mohamed A. Zayed, Mohamed A. Zayed, Mohamed A. Zayed, Mohamed A. Zayed   +7 more
doaj   +1 more source

Endothelial dysfunction in adolescents and young adults with nonalcoholic liver disease [PDF]

, 2019
Nonalcoholic liver disease is a global public health problem that increases cardiovascular morbidity and mortality in these patients. This paper discusses endothelial dysfunction among patients (adolescents and young adults) with nonalcoholic liver ...
Donoiu, Ionuț, Istrătoaie, Octavian, Moise, Cristiana G, Mustafa, Edme R, Rogoveanu, Ion, Tudorașcu, Diana R, TÂRTEA, Georgică C   +6 more
core   +1 more source

Developing evidence‐based, cost‐effective P4 cancer medicine for driving innovation in prevention, therapeutics, patient care and reducing healthcare inequalities

Molecular Oncology, EarlyView.
The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg, Joachim von Braun, Julio Celis, Anton Berns, Michael Baumann, Tit Albreht, Nancy Abou‐Zeid, Vanderlei Bagnato, Christian Brandts, Chien‐Jen Chen, Massimiliano di Pietro, Manjit Dosanjh, Thomas Dubois, Alexander Eggermont, Angelika Eggert, Ingemar Ernberg, Sara Faithfull, Johannes Förner, Stefan Fröhling, Manuel Heitor, Leroy Hood, Wei Jiang, Bengt Jönsson, Ravi Kannan, Maria Leptin, Su Li, Peter Lindgren, Douglas Lowy, Jun Ma, Alex Markham, Péter Nagy, Simon Oberst, M. Iqbal Parker, Danielle Rodin, Kevin Ryan, Joachim Schüz, Richard Sullivan, Josep Tabernero, Peter Turkson, Oliver Várhelyi, Harold Varmus, Chijie Wang, Elisabete Weiderpass, Nils Wilking   +43 more
wiley   +1 more source

Endoglin: a critical mediator of cardiovascular health

Vascular Health and Risk Management, 2013
Navin K Kapur,1 Kevin J Morine,1 Michelle Letarte2,31Molecular Cardiology Research Institute, Tufts Medical Center, Tufts University School of Medicine, Boston, Massachusetts, USA; 2Molecular Structure and Function Program, Hospital for Sick Children ...
Kapur NK, Morine KJ, Letarte M
doaj  

Association of Life’s Crucial 9 with all-cause and cardiovascular mortality in stroke survivors and predictive value for mortality compared with Life’s Essential 8: evidence from NHANES 2005–2018

Frontiers in Neurology
BackgroundThere is evidence of a positive correlation between depressive disorders and poor cardiovascular health (CVH). Recently, the inclusion of psychological health assessments into Life’s Essential 8 (LE8) has been put forward to enhance the ...
Xupeng Wu, Xiaofeng Li, Xiaofeng Li, Hong Liu   +3 more
doaj   +1 more source

Cardiovascular medication, physical activity and mortality: cross-sectional population study with ongoing mortality follow up [PDF]

, 2009
Objective: to establish physical activity levels in relation to cardiovascular medication and to examine if physical activity is associated with benefit independently of medication among individuals with no diagnosis of cardiovascular disease (CVD ...
Hamer, M., Primatesta, P., Stamatakis, E.   +2 more
core  

Status of cardiovascular health among adults in a rural area of Northwest China: Results from a cross-sectional study. [PDF]

, 2016
The aim of this study was to assess the status of cardiovascular health among a rural population in Northwest China and to determine the associated factors for cardiovascular health.A population-based cross-sectional study was conducted in the rural ...
Cao, Lei, Dang, Shaonong, Li, Qiang, Liu, Ruru, Marshall, Roger J, Pei, Leilei, Wang, Duolao, Yan, Hong, Yang, Ruihai, Zhao, Yaling   +9 more
core   +2 more sources

Phytoestrogens and cardiovascular health

Journal of the American College of Cardiology, 2000
Coronary artery disease is the leading overall cause of mortality for women and increases dramatically after menopause. Estrogen has many beneficial cardiovascular actions although concerns have been raised about its effects on the progression of breast and uterine neoplasms and its tendency to increase coagulability. Selective estrogen agonists may be
Wroblewski Lissin, Lynette, Cooke, John P   +1 more
openaire   +2 more sources

Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition

Molecular Oncology, EarlyView.
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li, Shuichi Tatarano, Hirofumi Yoshino, Saeki Saito, Mitsuhiko Tominaga, Junya Arima, Ikumi Fukuda, Takashi Sakaguchi, Ryosuke Matsushita, Yasutoshi Yamada, Hideki Enokida   +10 more
wiley   +1 more source