Results 241 to 250 of about 4,068,473 (311)

Beyond the review: additional non-oncologic drugs with clinically significant cardiovascular effects. [PDF]

Eur Heart J Cardiovasc Pharmacother
Van der Linden L, Vanassche T.
europepmc   +1 more source

Lactate‐Induced K370 Lactylation of STING Inhibits STING‐TBK1 Signaling and Dampens Anti‐Tumor Immunity

Advanced Science, EarlyView.
Lactate accumulation in glioblastoma drives lactylation of STING at lysine 370, a primate‐conserved residue. K370 lactylation weakens STING‐TBK1 binding, destabilizes STING, and disrupts ER‐to‐Golgi trafficking, blunting type I interferon signaling. LDHA inhibition reverses K370 lactylation and improves the antitumor efficacy of STING agonism combined ...
Yueyao Wu, Jingzhe Wang, Xu Chen, Yuntong Yang, Ping Wei, Han Xie, Honghao Wang, Chunyu Zhang, Siyi Xu, Qi Wang, Chunlong Zhong, Jing Zhang   +11 more
wiley   +1 more source

Leveraging bioinformatics approaches for drug repositioning in space radiation protection. [PDF]

PLoS One
Diaz TE, Kerrigan JA, Bowles DE, Kidane YH.   +3 more
europepmc   +1 more source

Treatment effects in contemporary cardiovascular pharmacotherapy: determinants and interpretation. [PDF]

Eur Heart J Cardiovasc Pharmacother
Rocca B.
europepmc   +1 more source

Comparative fatty acid profiling of irradiated canola varieties: insights from GC-MS metabolomics and molecular docking. [PDF]

RSC Adv
Younas Z, Ahmad I, Ullah F, Ilyas N, Hassan MU, Al Abdallah Q, Mashwani ZUR.   +6 more
europepmc   +1 more source

Sex differences in the associations of multidomain risk factor profiles with incident major adverse cardiovascular events. [PDF]

Front Cardiovasc Med
Yang Y, Chen X, Hu Y, Wang X, Wang H, Wei Y, Zhang F, Dong Z, Yu R.   +8 more
europepmc   +1 more source