Results 101 to 110 of about 102,004 (258)

A Soft Robotic Model for Simulating Heart Valve Disease and Cardiac Interventions

Advanced Science, EarlyView.
This paper introduces a fully synthetic fabrication methodology for a soft robotic, in‐vitro model of the left‐heart, complete with a functioning mitral valve apparatus. With a view towards patient‐specific modeling, we demonstrate physiological flow and pressure waveforms, tunable mitral valve function with clinical imaging compatibility, and its use ...
James Davies, Emanuele Nicotra, Kefan Zhu, Chi Cong Nguyen, Bibhu Sharma, Adrienne Ji, Phuoc Thien Phan, Jingjing Wan, Patrick Pruscino, Hermione Truong, Jelena Rnjak‐Kovacina, Hoang‐Phuong Phan, Christopher Hayward, Nigel Hamilton Lovell, Thanh Nho Do   +14 more
wiley   +1 more source

Unveiling systemic complexity: The role of artificial intelligence in integrative athlete monitoring [PDF]

Journal of Exercise & Organ Cross Talk
Dear Editor-in-ChiefWe are pleased to submit our manuscript, "Unveiling Systemic Complexity: The Role of Artificial Intelligence in Integrative Athlete Monitoring," for peer review and potential publication as a Letter in Exercise & Organ Crosstalk.
Mostafa Ghanei
doaj   +1 more source

Aerospace medicine and biology: A continuing bibliography with indexes, supplement 162, January 1977 [PDF]

This bibliography lists 189 reports, articles, and other documents introduced into the NASA scientific and technical information system in December ...

core   +1 more source

Detrended Fluctuation Analysis of Systolic Blood Pressure Control Loop

, 2009
We use detrended fluctuation analysis (DFA) to study the dynamics of blood pressure oscillations and its feedback control in rats by analyzing systolic pressure time series before and after a surgical procedure that interrupts its control loop. We found,
, Afifi A K, Bernardi L, C E C Galhardo, Carretta R, da Silva Soares P P, Echeverría J C, Eke A, Galhardo C E C Penna T J P de Menezes M A Soares P P, Guyton A C, Jacob F, Krieger E M, Langewitz W, M Argollo de Menezes, Mancia G, P P S Soares, Pagani M, Pagani M, Press W, Schreihofer A M, Smyth H S, T J P Penna, Virginia L B   +22 more
core   +1 more source

GPCRs in CAR‐T Cell Immunotherapy: Expanding the Target Landscape and Enhancing Therapeutic Efficacy

Advanced Science, EarlyView.
Chimeric antigen receptor T cell therapy faces dual challenges of target scarcity and an immunosuppressive microenvironment in solid tumors. This review highlights how G protein‐coupled receptors can serve as both novel targets to expand the therapeutic scope and functional modules to enhance CAR‐T cell efficacy.
Zhuoqun Liu, Yuchen Xiao, Yamin Zhao, Lihe Dai, David J.H. Shih, Shikang Liang, Honglei Tian, Liu Liu, Feng Tian, Bing Liu, Lei Chang, Chao Zhang   +11 more
wiley   +1 more source

Reprogramming heart failure: physiological orchestration and mechanistic decoding of exercise benefits

BMC Cardiovascular Disorders
Heart failure (HF) is a complex clinical syndrome caused by a variety of reasons leading to structural or functional damage to the heart and a decline in the heart’s pumping ability, and it is the endpoint of various cardiovascular diseases, which is ...
Longfei Xu, Congfei Chen, Kun Wang, Tianhui Wang   +3 more
doaj   +1 more source

Sirt3 Genetically Engineered Apoptotic Bodies Alleviate Skeletal Aging by Limiting Aggravated NLRP3 Inflammasome Activation of Senescent Macrophages

Advanced Science, EarlyView.
The senescence of macrophages leads to a decrease in the expression of Sirtuin3 (Sirt3), which in turn aggravates the NLRP3 inflammasome activation and IL‐1β secretion, thereby promoting the aging‐related osteoporosis. Sirt3‐enriched apoptotic bodies (ABs‐Sirt3) generated through genetic editing approaches can alleviate skeletal aging by targeting ...
Yanglin Wu, Shifeng Ling, Jiayi Mao, Hongyi Wang, Bo Wang, Zhenjia Che, Wenguo Cui, Ming Cai   +7 more
wiley   +1 more source

TRAP5 Inhibition Targeting Scar‐Associated Macrophages Ameliorates Acute Kidney Injury to Chronic Kidney Disease Transition

Advanced Science, EarlyView.
This study delineates macrophage heterogeneity along the acute kidney injury to chronic kidney disease transition. Single‐cell RNA sequencing reveals a TRAP5+ scar‐associated macrophage subset driven by Spp1–Cd44 signaling and mitochondrial metabolic reprogramming.
Chenxi Wang, Yaodong Gu, Wen Du, Lin Xie, Jinwei Quan, Yu Zhao, Ye Cheng, Zhaonan Wei, Yuanyuan Sha, Yi Wang, Dechao Xu, Xiang Gao, Min Chen, Xiangchen Gu   +13 more
wiley   +1 more source

First Generation Proteolysis Targeting Chimeras (PROTACs) for the Treatment of Progeria

Advanced Science, EarlyView.
We report the first PROTACs designed to degrade progerin, introducing a novel therapeutic approach for progeria. The best compound, UCM‐18142, significantly reduces progerin levels and improves key disease phenotypes in patient‐derived cells and in the LmnaG609G/G609G mouse model, paving the way for new treatment strategies targeting the root cause of ...
Jon Macicior‐Michelena, Marcelino Telechea, Daniel Fernández, Alba García‐Martín, Ángeles Canales, Silvia Ortega‐Gutiérrez   +5 more
wiley   +1 more source

The role of sex differences in cardiovascular, metabolic, and immune functions in health and disease: a review for “Sex Differences in Health Awareness Day”

Biology of Sex Differences
Sexual dimorphism is a fundamental characteristic of the anatomy and physiology of animals and humans, yet biomedical research has largely ignored these phenomena in the study of health and disease, despite early studies in the eighteenth and nineteenth ...
Lana McClements, Alexandra Kautzky-Willer, Georgios Kararigas, Sofia B. Ahmed, John N. Stallone   +4 more
doaj   +1 more source