Results 91 to 100 of about 1,590,210 (316)

Aging Is a Key Driver for Adult Acute Myeloid Leukemia

Aging and Cancer, EarlyView.
Acute myeloid leukemia (AML) is a classical age‐related hematologic malignancy, and a key driver of AML is aging, which profoundly regulates intrinsic factors such as genomic instability, epigenetic reprogramming, and metabolic dysregulation, and alters bone marrow microenvironment.
Rong Yin, Haojian Zhang
wiley   +1 more source

Super‐Refractory Status Epilepticus (SRSE) in a Patient With Compound Heterozygous OPA1 Variants: Case Report and Literature Review

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Super‐Refractory Status Epilepticus (SRSE) is a rare, life‐threatening neurological emergency with unclear etiology in many cases. Mitochondrial dysfunction, often due to disease‐causing genetic variants, is increasingly recognized as a cause, with each gene producing distinct pathophysiological mechanisms.
Pouria Mohammadi, Lara Basovic, Christopher Michael McGraw   +2 more
wiley   +1 more source

Cardiovascular risk factors

, 2021
Cardiovascular diseases are caused by a combination of several factors, including genetics, cultural, psychosocial factors. While some of the factors are not under the control of the individual, there are some risk factors that an individual can modify.
Vakilzadehian, Niyousha
core  

Integrating information from novel risk factors with calculated risks: the critical impact of risk factor prevalence [PDF]

, 2011
Case vignette: a 60-year-old man visits his physician for assessment of his 10-year cardiovascular risk. On the basis of his systolic blood pressure, lipid profile, smoking status, and the fact that he is nondiabetic, the Framingham risk score estimates ...
Kostende, P.J., Physical and Colloid Chemistry, Kostense, P.J., Yvo M. Smulders, Jan Groenewold, Sattar, N., Albertus J. Kooter, Groenewold, J., Naveed Sattar, Thijs, A., Kooter, A.J., Sub Physical and Colloid Chemistry, Piet J. Kostense, Abel Thijs, Smulders, Y.M.   +14 more
core   +1 more source

Subcutaneous Administration of Apolipoprotein J-Derived Mimetic Peptide d-[113–122]apoJ Improves LDL and HDL Function and Prevents Atherosclerosis in LDLR-KO Mice

Biomolecules, 2020
Mimetic peptides are potential therapeutic agents for atherosclerosis. d-[113–122]apolipoprotein (apo) J (d-[113–122]apoJ) is a 10-residue peptide that is predicted to form a class G* amphipathic helix 6 from apoJ; it shows anti-inflammatory and anti ...
Andrea Rivas-Urbina, Anna Rull, Joile Aldana-Ramos, David Santos, Nuria Puig, Nuria Farre-Cabrerizo, Sonia Benitez, Antonio Perez, David de Gonzalo-Calvo, Joan Carles Escola-Gil, Josep Julve, Jordi Ordoñez-Llanos, Jose Luis Sanchez-Quesada   +12 more
doaj   +1 more source

Genes and cardiovascular risk [PDF]

European Heart Journal, 2012
This editorial refers to ‘Influence of common genetic variation on blood lipid levels, cardiovascular risk, and coronary events in two British prospective cohort studies’[†][1], by S. Shah et al. , 972 and ‘Impact of common genetic variation on response to simvastatin therapy among 18 705 participants in the Heart Protection Study’[‡][2], by J.C ...
openaire   +2 more sources

Spinal Cord Infarction Versus Idiopathic Transverse Myelitis: Clinical, Radiological, and Functional Insights From a Retrospective Cohort Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Introduction Spinal cord infarction (SCI) is a rare but devastating myelopathy, characterized by a high disability rate and an unfavorable prognosis. It has often been underdiagnosed and misdiagnosed as idiopathic transverse myelitis (ITM). This study aimed to describe the clinical features, radiological biomarkers, treatments, and functional ...
Zeqiang Ji, Jianlong Zhang, Yiming Shi, Shiyu Shan, Yang Du, Guangshuo Li, Ying Jin, Yani Zhang, Chuanying Wang, Yijun Lin, Yuhao Guo, Decai Tian, Xingquan Zhao, Tian Song   +13 more
wiley   +1 more source

Changes in physical activity are associated with changes in metabolic cardiovascular risk factors. [PDF]

, 2001
AIMS/HYPOTHESIS: To investigate the effect of changes in physical activity on changes in metabolic cardiovascular risk factors and to investigate what factors affect the association between physical activity and cardiovascular mortality.
Zethelius, B, Lithell, H.O.,, McKeigue, PM, Zethelius, B,, Lithell, HO, McKeigue, P.M., Byberg, Liisa,, Byberg, L   +7 more
core   +1 more source

Clustering Algorithm Reveals Dopamine‐Motor Mismatch in Cognitively Preserved Parkinson's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To explore the relationship between dopaminergic denervation and motor impairment in two de novo Parkinson's disease (PD) cohorts. Methods n = 249 PD patients from Parkinson's Progression Markers Initiative (PPMI) and n = 84 from an external clinical cohort.
Rachele Malito, Chiara Meneghini, Alice Galli, Luca Gallo, Pierfrancesco Mitrotti, Paola Dimartino, Marianna Inglese, Cinzia Zatti, Alessandro Lupini, Andrea Pilotto, Alessandro Padovani, Micol Avenali, Enza Maria Valente, Cristina Tassorelli, Silvia P. Caminiti   +14 more
wiley   +1 more source

Trends in cardiovascular risk factors in poland: results from the comprehensive cardiovascular risk prevention program

Background: Cardiovascular diseases (CVDs) are the leading cause of mortality globally and in Poland. This study assessed the prevalence and trends of cardiovascular (CV) risk factors in the Polish population over time.
Jakubiak, Grzegorz K., Magdalena Lisiak, Uchmnaowicz, Izabella, Christopher S. Lee, Grzegorz K. Jakubiak, Marta Wleklik, Andrzej Mysiak, Lee, Christopher S., Czapla, Michał, Mysiak, Andrzej, Grzegorz Kubielas, Lisiak, Magdalena, Michał Czapla, Izabella Uchmanowicz, Wleklik, Marta, Stanisław Surma, Kubielas, Grzegorz, Czapla, Michał [0000-0002-4245-5420], Surma, Stanisław   +18 more
core   +1 more source