Results 71 to 80 of about 2,380,266 (312)

Chemokines and Cardiovascular Risk [PDF]

Arteriosclerosis, Thrombosis, and Vascular Biology, 2008
Based on the importance of inflammation in atherogenesis, recent work has focused on whether plasma markers of inflammation can noninvasively diagnose and prognosticate atherosclerotic disorders. Although several studies support an important pathogenic role of chemokines in atherosclerosis, potentially representing attractive therapeutic targets in ...
Pål, Aukrust, Bente, Halvorsen, Arne, Yndestad, Thor, Ueland, Erik, Øie, Kari, Otterdal, Lars, Gullestad, Jan K, Damås   +7 more
openaire   +2 more sources

Screening and epitope characterization of Nidogen‐2‐specific nanobodies

FEBS Open Bio, EarlyView.
Camel immunization and phage display were employed to generate high‐affinity VHH nanobodies against Nidogen‐2. After library construction, biopanning, ELISA screening, sequencing, and recombinant expression, selected nanobodies were purified and characterized, leading to the preliminary exploration of a nanobody‐based sandwich ELISA for specific ...
Jianchuan Wen, Qianqian Cui, Zhongyun Lan, Yingjun Wang, Shuaiying Zhao, Wenxuan Feng, Yunfeng Liu, Qiting Huang, Dongna Zhang, Jianfeng Xu   +9 more
wiley   +1 more source

Cardiovascular risk factors, global cardiovascular risk, and vascular age in a cohort of Peruvian HIV patients

HIV & AIDS Review. International Journal of HIV-Related Problems
Introduction Data on cardiovascular risk and vascular age in patients with human immunodeficiency virus (HIV) from developing countries are scarce. Therefore, the current study aimed to determine the prevalence of cardiovascular risk factors, global ...
German Valenzuela-Rodriguez, Jaime A. Collins, Raul Castillo, Luis R. Illescas, Adrian V. Hernandez, Carlos Diaz-Arocutipa   +5 more
doaj   +1 more source

Lipid lowering with inclisiran: a real-world single-centre experience

Open Heart, 2022
Objective The reduction in circulating low-density lipoprotein cholesterol (LDL-c) is the primary aim of lipid-lowering therapies as a method of atherosclerotic cardiovascular disease risk reduction.
Jaimini Cegla, Ben Jones, Kausik K Ray, Stewart Wilson, Ferruccio De Lorenzo, Pritpal Padam, Lucy Barton, Alessia David, Shahenaz Walji   +8 more
doaj   +1 more source

The cardiovascular safety of incretin-based therapies: a review of the evidence [PDF]

, 2013
Cardiovascular disease (CVD) is a leading cause of morbidity and mortality in people with diabetes and therefore managing cardiovascular (CV) risk is a critical component of diabetes care. As incretin-based therapies are effective recent additions to the
Petrie, J.R.
core   +2 more sources

Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum

FEBS Open Bio, EarlyView.
Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik, Russell Pickford, Hannah C. Timmins, Olivier Piguet, Glenda M. Halliday, Matthew C. Kiernan, Woojin Scott Kim   +6 more
wiley   +1 more source

Does sticky blood predict a sticky end? Associations of blood viscosity, haematocrit and fibrinogen with mortality in the West of Scotland [PDF]

, 2003
There is increasing evidence that blood viscosity and its major determinants (haematocrit, plasma viscosity and fibrinogen) are associated with an increased risk of incident cardiovascular events; however, their associations with mortality are not ...
Ann Rumley, Danesh, Danesh, Gordon D. O. Lowe, Heart Protection Study Collaborative Group, Hugh Tunstall-Pedoe, Koenig, Lee, Lee, Lowe, Lowe, Lowe, Lowe, Lowe, Lowe, Lowe, Lowe, Mark Woodward, Meade, Millar, Progress Collaborative Group, Rose, Smith, Smith, Sweetnam, Tunstall-Pedoe, Von Clauss, Wannamethee, Woodward, Woodward   +29 more
core   +1 more source

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

FEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer, Angelique Kragl, Katrin Ziems, Juliane Glaubitz, Sophie Grammbauer, Susanne Hildebrandt, Mladen V. Tzvetkov, Gabriele Jedlitschky   +7 more
wiley   +1 more source

Electronic Cigarettes and Cardiovascular Risk: Caution Waiting for Evidence

European Cardiology Review, 2019
Electronic cigarettes use is a growing trend in contemporary societies, with the propensity to compete with traditional tobacco smoking. Some preclinical studies demonstrated the toxic and detrimental effects of electronic cigarettes liquid components ...
Domenico D’Amario, Stefano Migliaro, Josip Andjelo Borovac, Rocco Vergallo, Mattia Galli, Attilio Restivo, Matteo Bonini, Enrico Romagnoli, Antonio Maria Leone, Filippo Crea   +9 more
doaj   +1 more source

Cardiovascular risk profile and frailty in a population-based study of older British men. [PDF]

, 2014
BACKGROUND: Frailty in older age is known to be associated with cardiovascular disease (CVD) risk. However, the extent to which frailty is associated with the CVD risk profile has been little studied. Our aim was to examine the associations of a range of
Afilalo, Bastos-Barbosa, Bergmeyer, Bowers, Chang, Chaves, Clegg, Cole, Collard, Fried, Gindler, Hill, Le Couteur, Levey, Levy, Nauck, Peake, Rockwood, Stankov, Szanton, Thomas, Trinder, Walker, Weissman, Wilhelm-Leen, Xue   +25 more
core   +1 more source