Results 61 to 70 of about 7,309,579 (256)

Electronic Cigarettes and Cardiovascular Risk: Caution Waiting for Evidence

European Cardiology Review, 2019
Electronic cigarettes use is a growing trend in contemporary societies, with the propensity to compete with traditional tobacco smoking. Some preclinical studies demonstrated the toxic and detrimental effects of electronic cigarettes liquid components ...
Domenico D’Amario, Stefano Migliaro, Josip Andjelo Borovac, Rocco Vergallo, Mattia Galli, Attilio Restivo, Matteo Bonini, Enrico Romagnoli, Antonio Maria Leone, Filippo Crea   +9 more
doaj   +1 more source

In silico and in vitro exploration of a tyrosinase for biocatalytic production of catechols

FEBS Open Bio, EarlyView.
Tyrosinase from Ralstonia pseudosolanacearum is a promising biocatalyst for producing valuable catechols from monophenol substrates. This tyrosinase is uniquely suited to this due to its high monophenolase : diphenolase ratio. We combined in silico docking and in vivo kinetic characterisation of this tyrosinase with 11 industrially relevant monophenols,
James Britton, Fang Zhao, Reeta Davis, Meg Walsh, Kevin E O'Connor, David O'Connell, Tanja Narancic   +6 more
wiley   +1 more source

Associations between the neural-hematopoietic-inflammatory axis and DNA methylation of stress-related genes in human leukocytes: Data from the Washington, D.C. cardiovascular health and needs assessment

Brain, Behavior, & Immunity - Health
Chronic stress is associated with cardiovascular disease (CVD) risk and elevated amygdala activity. Previous research suggests a plausible connection between amygdala activity, hematopoietic tissue activity, and cardiovascular events; however, the ...
Manuel A. Cintron, Yvonne Baumer, Alina P.S. Pang, Elizabeth M. Aquino Peterson, Lola R. Ortiz-Whittingham, Joshua A. Jacobs, Sonal Sharda, Kameswari A. Potharaju, Andrew S. Baez, Cristhian A. Gutierrez-Huerta, Erika N. Ortiz-Chaparro, Billy S. Collins, Valerie M. Mitchell, Abhinav Saurabh, Laurel G. Mendelsohn, Neelam R. Redekar, Subrata Paul, Michael J. Corley, Tiffany M. Powell-Wiley   +18 more
doaj   +1 more source

Five‐Year Outcomes of Laparoscopic Sphincter‐Preserving Surgery for Rectal Cancer: A Prospective Study in Elderly Vietnamese Patients

Aging and Cancer, EarlyView.
This prospective study demonstrates that laparoscopic sphincter‐preserving surgery is feasible for elderly patients. While overall survival reaches 70% at 5 years, advanced T‐stage and the omission of neoadjuvant therapy significantly drive recurrence, highlighting the need for personalized geriatric protocols despite logistical challenges.
Huu Duc Ho, Quang Le, Ngoc Thach Tran, Van Viet Ung, Loc Vu   +4 more
wiley   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

Debate: Testosterone Therapy Reduces Cardiovascular Risk in Men with Diabetes. Against the Motion

, 2015
© 2015, Springer Science+Business Media New York. Observationally, men with low testosterone are more vulnerable to type 2 diabetes (T2DM). In meta-analysis of, albeit small, randomized controlled trials (RCTs) giving men testosterone improves glucose ...
Xu, Lin, Schooling, C. Mary, Zhao, Jie
core   +1 more source

Understanding and Mitigating the Risk of Accelerated Biological Aging in Survivors of Cancer: A Scoping Review

Aging and Cancer, EarlyView.
Cancer treatment is associated with measurable acceleration of biological aging across epigenetic, telomere, senescence, and immune biomarkers. However, biomarker validation and interventional strategies remain limited, especially in hematologic malignancies, underscoring the need for standardized multi‐omic aging assessments and adequately powered ...
Moataz Ellithi, Emily Herdman, Danielle Westmark, Vijaya R. Bhatt   +3 more
wiley   +1 more source

Helicobacter pylori and Early Vascular Aging: Endothelial Dysfunction, Arterial Stiffness, and Conditional Cardiovascular Vulnerability

Current Issues in Molecular Biology
Helicobacter pylori (H. pylori) infection has been investigated as a potential contributor to extra-gastric vascular injury, although its cardiovascular relevance remains uncertain and context-dependent. This state-of-the-art narrative review synthesizes
Federica Fogacci, Giulia Fiorini, Cristina Scollo, Claudio Borghi, Dino Vaira, Arrigo Francesco Giuseppe Cicero   +5 more
doaj   +1 more source

The Role of Calcitonin Gene‐Related Peptide in High‐Altitude Headache: A Prospective Field Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective High‐altitude headache (HAH) is a common neurological condition associated with rapid ascent to high altitude. The pathophysiological mechanisms underlying HAH remain incompletely understood. Calcitonin gene‐related peptide (CGRP), a neuropeptide implicated in migraine pathophysiology, may play a key role in the pathophysiology of ...
Roman Schniepp, Ludwig Karrasch, Helena Breitenstein, Andreas Straube, Katharina Kamm   +4 more
wiley   +1 more source

Evidence on the prevalence and geographic distribution of major cardiovascular risk factors in Italy [PDF]

, 2013
Objective: To assess the prevalence and geographic distribution of major cardiovascular risk factors in a large community-wide sample of the Italian population. Design: A cross-sectional survey.
Guida, Bruna, Laccetti R, Falconi, Claudio, Pota, Andrea, Falconi C, Bardaro, Leopoldo, Bardaro L, Laccetti, Roberta, Stranges, Saverio, Pota A, Memoli, Bruno, Stranges S   +11 more
core   +1 more source