Results 41 to 50 of about 7,309,579 (256)

The efficiency of cardiovascular risk assessment: do the right patients get statin treatment? [PDF]

, 2013
OBJECTIVE: To evaluate targeting of statin prescribing for primary prevention to those with high cardiovascular disease (CVD) risk. DESIGN: Two cohort studies including the general population and initiators of statins aged 35-74 years.
Van Staa, Tjeerd; id_orcid, van Staa, Tjeerd-Pieter, Gulliford, Martin, Goldacre, Ben, Smeeth, Liam, Ng, Edmond S-W   +5 more
core   +1 more source

Chronic kidney disease progression in patients with previous type 2 diabetes and/or hypertension: a population-based cohort study from primary care in Spain

BMJ Open
Objectives To evaluate whether between hypertension and type 2 diabetes (T2D)—established drivers of chronic kidney disease (CKD) progression—one might be more strongly associated with CKD progression than the other.Design Cohort study using a primary ...
David Vizcaya, Betlem Salvador-González, Oriol Cunillera-Puértolas, Sílvia Cobo-Guerrero, José Romano-Sánchez, Daniel Bundó-Luque, Ariadna Arbiol-Roca   +6 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Cardiovascular risk assessment and management in rheumatoid arthritis : are guidelines being followed? [PDF]

, 2014
Aim: The aim of the audit was to determine whether the cardiovascular risk assessment and management in rheumatoid arthritis patients at Mater Dei Hospital is in concordance with the recommendations by the European League Against Rheumatism (EULAR ...
Borg, Andrew A., Magro, Rosalie, Buhagiar, Malcolm, Taliana, Nikita   +3 more
core  

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Cardiovascular risk protection from the Mediterranean diet and olive oil. A transcriptomic update in humans

Grasas y Aceites, 2016
This review highlights the human studies that explore the benefits of the Mediterranean diet and olive oil, based on gene expression analysis. We summarized consistent human transcriptomic studies on cardiovascular risk, based on TMD and olive oil ...
S. Carrión, L. Torres, O. Castañer
doaj   +1 more source

Efficacy and safety of inclisiran a newly approved FDA drug: a systematic review and pooled analysis of available clinical studies

American Heart Journal Plus, 2022
Study objective: This systematic review and meta-analysis aimed to assess the efficacy and safety profile of treatment with inclisiran, a drug that has been recently approved by the United States Food and Drug Administration (FDA) and the European ...
Arrigo F.G. Cicero, Federica Fogacci, Alberto Zambon, Peter P. Toth, Claudio Borghi   +4 more
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Socioeconomic position in childhood and adult cardiovascular risk factors, vascular structure, and function: cardiovascular risk in Young Finns study [PDF]

, 2005
Objective: To examine the association of childhood socioeconomic position (SEP) with adult cardiovascular risk factors, vascular structure, and vascular function in a contemporary population of young adults. Design: Population based prospective cohort
Keltikangas-Järvinen, L., Kivimäki, M, Ferrie, J E, Keltikangas-Järvinen, L, Raitakari, O.T., Raitakari, O T, Elovainio, M., Viikari, J.S.A., Vahtera, J, Elovainio, M, Juonala, M., Viikari, J S A, Vahtera, J., Leino, M, Pulkki-Råback, L., Smith, Davey G, Davey Smith, G., Ferrie, J.E., Juonala, M, Leino, M., Pulkki-Råback, L, Kivimäki, M.   +21 more
core  

Asian Cohort Studies on Cardiovascular Risk Factors in Childhood [PDF]

, 2019
Long-term cohort studies have shown that cardiovascular risk factors measured during childhood were associated with levels of adult cardiovascular risk factors and also with the lifetime risk of cardiovascular disease (CVD).
김현창, 정선재, 서일
core   +1 more source