Results 81 to 90 of about 1,590,210 (316)

Screening and epitope characterization of Nidogen‐2‐specific nanobodies

FEBS Open Bio, EarlyView.
Camel immunization and phage display were employed to generate high‐affinity VHH nanobodies against Nidogen‐2. After library construction, biopanning, ELISA screening, sequencing, and recombinant expression, selected nanobodies were purified and characterized, leading to the preliminary exploration of a nanobody‐based sandwich ELISA for specific ...
Jianchuan Wen, Qianqian Cui, Zhongyun Lan, Yingjun Wang, Shuaiying Zhao, Wenxuan Feng, Yunfeng Liu, Qiting Huang, Dongna Zhang, Jianfeng Xu   +9 more
wiley   +1 more source

Lipid lowering with inclisiran: a real-world single-centre experience

Open Heart, 2022
Objective The reduction in circulating low-density lipoprotein cholesterol (LDL-c) is the primary aim of lipid-lowering therapies as a method of atherosclerotic cardiovascular disease risk reduction.
Jaimini Cegla, Ben Jones, Kausik K Ray, Stewart Wilson, Ferruccio De Lorenzo, Pritpal Padam, Lucy Barton, Alessia David, Shahenaz Walji   +8 more
doaj   +1 more source

Debate: Testosterone Therapy Reduces Cardiovascular Risk in Men with Diabetes. Against the Motion

, 2015
© 2015, Springer Science+Business Media New York. Observationally, men with low testosterone are more vulnerable to type 2 diabetes (T2DM). In meta-analysis of, albeit small, randomized controlled trials (RCTs) giving men testosterone improves glucose ...
Xu, Lin, Schooling, C. Mary, Zhao, Jie
core   +1 more source

Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum

FEBS Open Bio, EarlyView.
Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik, Russell Pickford, Hannah C. Timmins, Olivier Piguet, Glenda M. Halliday, Matthew C. Kiernan, Woojin Scott Kim   +6 more
wiley   +1 more source

Cardiovascular risk profile and frailty in a population-based study of older British men. [PDF]

, 2015
Frailty in older age is known to be associated with cardiovascular disease (CVD) risk. However, the extent to which frailty is associated with the CVD risk profile has been little studied.
Papacosta, AO, Arianayagam, DS, Whincup, PH, Ramsay, SE, Iliffe, S, Lennon, LT, Cryer, J, Wannamethee, SG   +7 more
core   +1 more source

Electronic Cigarettes and Cardiovascular Risk: Caution Waiting for Evidence

European Cardiology Review, 2019
Electronic cigarettes use is a growing trend in contemporary societies, with the propensity to compete with traditional tobacco smoking. Some preclinical studies demonstrated the toxic and detrimental effects of electronic cigarettes liquid components ...
Domenico D’Amario, Stefano Migliaro, Josip Andjelo Borovac, Rocco Vergallo, Mattia Galli, Attilio Restivo, Matteo Bonini, Enrico Romagnoli, Antonio Maria Leone, Filippo Crea   +9 more
doaj   +1 more source

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

FEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer, Angelique Kragl, Katrin Ziems, Juliane Glaubitz, Sophie Grammbauer, Susanne Hildebrandt, Mladen V. Tzvetkov, Gabriele Jedlitschky   +7 more
wiley   +1 more source

Cyclic azapeptide CD36 ligand attenuates cardiac injury and reduces long‐chain fatty acid accumulation after myocardial ischemia–reperfusion in mice

FEBS Open Bio, EarlyView.
In a murine model of myocardial ischemia and reperfusion (MI/R), the CD36 azapeptide ligand MPE‐298 reduces cardiac injury and transiently lowers left ventricular long‐chain fatty acids (LCFAs) accumulation 3 h after reperfusion, accompanied by a decrease of oxidative stress and inflammation‐associated genes' expression in the heart and adipose tissue.
Jade Gauvin, Naghme Radmannia, David N. Huynh, Liliane Ménard, Caroline Daneault, Maïté Veilleux, Ahsanullah Ahsanullah, André C. Carpentier, William D. Lubell, Matthieu Ruiz, Huy Ong, Sylvie Marleau, Simon‐Pierre Gravel   +12 more
wiley   +1 more source

A new flow chip in combination with multiphoton microscopy as a protocol for longitudinal 3D imaging of tissue calcification under shear stress

FEBS Open Bio, EarlyView.
Miniaturized flow chip platform enabling continuous perfusion and longitudinal multiphoton 3D imaging of vascular smooth muscle cell constructs under physiological flow. Brightfield imaging guides region selection, while CellTracker Green and mRuby‐labeled fetuin‐A visualize cells and mineral deposition, respectively. Magnesium supplementation markedly
Vytautas Kučikas, Aaron D. Morgan, Ignas Čiurlionis, Christian Böhm, Stefan Jockenhövel, Willi Jahnen‐Dechent, Marc A. M. J. van Zandvoort   +6 more
wiley   +1 more source

Associations between the neural-hematopoietic-inflammatory axis and DNA methylation of stress-related genes in human leukocytes: Data from the Washington, D.C. cardiovascular health and needs assessment

Brain, Behavior, & Immunity - Health
Chronic stress is associated with cardiovascular disease (CVD) risk and elevated amygdala activity. Previous research suggests a plausible connection between amygdala activity, hematopoietic tissue activity, and cardiovascular events; however, the ...
Manuel A. Cintron, Yvonne Baumer, Alina P.S. Pang, Elizabeth M. Aquino Peterson, Lola R. Ortiz-Whittingham, Joshua A. Jacobs, Sonal Sharda, Kameswari A. Potharaju, Andrew S. Baez, Cristhian A. Gutierrez-Huerta, Erika N. Ortiz-Chaparro, Billy S. Collins, Valerie M. Mitchell, Abhinav Saurabh, Laurel G. Mendelsohn, Neelam R. Redekar, Subrata Paul, Michael J. Corley, Tiffany M. Powell-Wiley   +18 more
doaj   +1 more source