Results 101 to 110 of about 10,143,464 (406)

The Evolving Understanding and Approach to Residual Cardiovascular Risk Management

Frontiers in Cardiovascular Medicine, 2020
Despite unprecedented advances in treatment of atherosclerotic cardiovascular disease, it remains the leading cause of death and disability worldwide. Treatment of major traditional risk factors, including low-density lipoprotein-cholesterol, serves as ...
Devinder S. Dhindsa, P. Sandesara, M. Shapiro, N. Wong   +3 more
semanticscholar   +1 more source

Overview of molecular signatures of senescence and associated resources: pros and cons

FEBS Open Bio, EarlyView.
Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas, Sylvia Vagena, Pavlos Pantelis, Giorgos Theocharous, Russel Petty, Konstantinos Evangelou, Vassilis G. Gorgoulis   +6 more
wiley   +1 more source

Dietary nitrate and nitrite protect against doxorubicin‐induced cardiac fibrosis and oxidative protein damage in tumor‐bearing mice

FEBS Open Bio, EarlyView.
Chemotherapies such as doxorubicin can have toxic effects on healthy cardiovascular/heart tissue. Following up on a doxorubicin toxicity study in mice without tumors where nitrate water was cardioprotective (lessened toxicity), this study with tumor‐bearing mice undergoing doxorubicin treatment showed no negative effect of nitrate and nitrite on drug ...
Rama D. Yammani, Xiaofei Chen, Nildris Cruz‐Diaz, Xuewei Zhu, Swati Basu, Daniel B. Kim‐Shapiro, David R. Soto‐Pantoja, Leslie B. Poole   +7 more
wiley   +1 more source

COVID-19 and the cardiovascular system: implications for risk assessment, diagnosis, and treatment options

Cardiovascular Research, 2020
The novel coronavirus disease (COVID-19) outbreak, caused by SARS-CoV-2, represents the greatest medical challenge in decades. We provide a comprehensive review of the clinical course of COVID-19, its comorbidities, and mechanistic considerations for ...
T. Guzik, Saidi A Mohiddin, A. Dimarco, V. Patel, K. Savvatis, F. Marelli-Berg, M. Madhur, M. Tomaszewski, P. Maffia, F. D’Acquisto, S. Nicklin, A. Marian, R. Nosalski, E. Murray, B. Guzik, C. Berry, R. Touyz, R. Kreutz, Daowen Wang, D. Bhella, Orlando Sagliocco, F. Crea, E. Thomson, I. McInnes   +23 more
semanticscholar   +1 more source

Diabetes‐induced vascular calcification is associated with low pyrophosphate and its oral supplementation prevents calcification in diabetic mice

FEBS Open Bio, EarlyView.
Induction of diabetes in three different mouse strains uniformly resulted in an increase in TNAP activity and a reduction in pyrophosphate (PPi) in the circulation. Inhibition of TNAP restored plasma PPi. Diabetes‐induced calcification in the media layer of the aorta was detected only in the Abcc6−/− strain, which is predisposed to ectopic ...
Krisztina Fülöp, Eszter Kozák, Natália Tőkési, Lilian Kocsis, Anikó Kelemen, Zsuzsanna Geszti, Adriána Kutás, Mariann Harangi, Ágnes Diószegi, Zsolt Rapi, József Balla, Olivier Le Saux, András Váradi, Viola Pomozi   +13 more
wiley   +1 more source

Associations between the neural-hematopoietic-inflammatory axis and DNA methylation of stress-related genes in human leukocytes: Data from the Washington, D.C. cardiovascular health and needs assessment

Brain, Behavior, & Immunity - Health
Chronic stress is associated with cardiovascular disease (CVD) risk and elevated amygdala activity. Previous research suggests a plausible connection between amygdala activity, hematopoietic tissue activity, and cardiovascular events; however, the ...
Manuel A. Cintron, Yvonne Baumer, Alina P.S. Pang, Elizabeth M. Aquino Peterson, Lola R. Ortiz-Whittingham, Joshua A. Jacobs, Sonal Sharda, Kameswari A. Potharaju, Andrew S. Baez, Cristhian A. Gutierrez-Huerta, Erika N. Ortiz-Chaparro, Billy S. Collins, Valerie M. Mitchell, Abhinav Saurabh, Laurel G. Mendelsohn, Neelam R. Redekar, Subrata Paul, Michael J. Corley, Tiffany M. Powell-Wiley   +18 more
doaj   +1 more source

Suggestive evidence of a multi-cytokine resistin pathway in humans and its role on cardiovascular events in high-risk individuals [PDF]

, 2017
In cells and tissues resistin affects IL-1β, IL-6, IL-8, IL-12 and TNF-α expression, thus suggesting the existence of a multi-cytokine "resistin pathway".
Antonucci, Alessandra, Copetti, Massimiliano, De Bonis, Concetta, Di Paola, Rosa, Marucci, Antonella, Menzaghi, Claudia, Ortega Moreno, Lorena, Salvemini, Lucia, Trischitta, Vincenzo   +8 more
core   +1 more source

Pathogenic Neurofibromatosis type 1 gene variants in tumors of non‐NF1 patients and role of R1276

FEBS Open Bio, EarlyView.
Somatic variants of the neurofibromatosis type 1 (NF1) gene occur across neoplasms without clinical manifestation of the disease NF1. We identified emerging somatic pathogenic NF1 variants and hotspots, for example, at the arginine finger 1276. Those missense variants provide fundamental information about neurofibromin's role in cancer.
Mareike Selig, Swanhild Lohse, Sara Elahi, Nils Hartmann, Stefanie Deckert, Shutian Si, Alexander Desuki, Anja Harder   +7 more
wiley   +1 more source

Subcutaneous Administration of Apolipoprotein J-Derived Mimetic Peptide d-[113–122]apoJ Improves LDL and HDL Function and Prevents Atherosclerosis in LDLR-KO Mice

Biomolecules, 2020
Mimetic peptides are potential therapeutic agents for atherosclerosis. d-[113–122]apolipoprotein (apo) J (d-[113–122]apoJ) is a 10-residue peptide that is predicted to form a class G* amphipathic helix 6 from apoJ; it shows anti-inflammatory and anti ...
Andrea Rivas-Urbina, Anna Rull, Joile Aldana-Ramos, David Santos, Nuria Puig, Nuria Farre-Cabrerizo, Sonia Benitez, Antonio Perez, David de Gonzalo-Calvo, Joan Carles Escola-Gil, Josep Julve, Jordi Ordoñez-Llanos, Jose Luis Sanchez-Quesada   +12 more
doaj   +1 more source

Blood rheology, cardiovascular risk factors, and cardiovascular disease: The West of Scotland Coronary Prevention Study [PDF]

, 2000
The West of Scotland Coronary Prevention Study (WOSCOPS) showed that pravastatin reduced the risk of coronary heart disease (CHD) events in 6,595 middle-aged hypercholesterolaemic men aged 45-64 years without prior myocardial infarction followed for an ...
Ann Rumley, Christopher Packard, Gordon Lowe, Ian Ford, James Shepherd, John Norrie, null null, Peter Macfarlane, Stuart Cobbe   +8 more
core   +1 more source