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Age and the Cardiovascular System
New England Journal of Medicine, 1992DESPITE the decline in rates of mortality due to heart disease during the past two decades, cardiovascular disease remains the most frequent single cause of death among persons over 65 years of age.1 2 3 It also accounts for a major and growing proportion of hospitalizations and health care costs and is a leading cause of morbidity among older people.2
Franklin H. Epstein, Jeanne Y. Wei
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Aquaporins in Cardiovascular System
2017Recent studies have shown that some aquaporins (AQPs ), including AQP1, AQP4, AQP7 and AQP9, are expressed in endothelial cells, vascular smooth muscle cells and heart of cardiovascular system. These AQPs are involved in the cardiovascular function and in pathological process of related diseases, such as cerebral ischemia , congestion heart failure ...
Lu, Tie +3 more
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Arrestins in the Cardiovascular System
2013Of the four mammalian arrestins, only the β-arrestins (βarrs; Arrestin2 and -3) are expressed throughout the cardiovascular system, where they regulate, as either desensitizers/internalizers or signal transducers, several G-protein-coupled receptors (GPCRs) critical for cardiovascular homeostasis.
Anastasios, Lymperopoulos +1 more
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Sleep and the Cardiovascular System
2013There is a close relationship between the cardiovascular and respiratory systems, and between these systems and sleep, leading in turn to peculiar cardiovascular and respiratory changes during the sleep-wake cycle. Physiological changes during sleep may be disrupted in several pathological conditions, where cardiovascular and sleep alterations can be ...
Parati, G, Lombardi, C, Mancia, G
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Hypothyroidism and cardiovascular system
Clinical Medicine (Russian Journal), 2016The article presents data on the relationship between thyroid dysfunction and cardiovascular diseases. The role of dyslipidemia, adipokines (adiponectin, leptin, resistin), C-reactive protein, deficiency of vitamin D3 in the development of cardiovascular disease in hypothyroidism is discussed.
A F, Verbovoy +4 more
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MicroRNAs in the cardiovascular system
Current Opinion in Cardiology, 2011Reprogramming of gene expression underlies the mechanisms involved in cardiac pathogenesis. MicroRNAs (miRNAs) are unique posttranscriptional regulators of gene expression whose function in cardiac development and disease has recently begun to unravel. In addition, they are potentially highly effective therapeutic tools.
Mingyue, Han +2 more
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Ghrelin and the Cardiovascular System
2014Ghrelin is a peptide that was originally isolated from the stomach. It exerts potent growth hormone (GH)-releasing and orexigenic activities. Several studies have highlighted the therapeutic benefits of ghrelin for the treatment of cardiovascular disease. In animal models of chronic heart failure, the administration of ghrelin improved cardiac function
Takeshi, Tokudome +3 more
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Osteopontin and cardiovascular system
Molecular and Cellular Biochemistry, 2006A matricellular protein, osteopontin (OPN), is expressed in response to mechanical stress and similar stimuli in the heart, integrates the inter-ECM signal transduction network of component cells, and maintains efficient contractility through quantitative and qualitative control of extracellular matrix (ECM) proteins. In particular, OPN is re-expressed
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Age and the cardiovascular system
Hospital Medicine, 1999Congestive heart failure is a common cause of morbidity and mortality in the elderly population. Important changes occur in the structure and function of the cardiovascular system with advancing age. An understanding of these changes is vital for optimum management of these patients.
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Cardiovascular and respiratory systems
2008Abstract In this chapter it is emphasized how, compared to other systems, little is known about the mechanisms of placebo and placebo-related effects in both the cardiovascular and respiratory systems. Side effects in placebo groups of cardiovascular clinical trials are common and might represent the basis of nocebo effects, although no ...
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