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Ketones and the cardiovascular system
Nature Cardiovascular Research, 2023Ketone bodies, the main one being β-hydroxybutyrate, have emerged as important regulators of the cardiovascular system. In healthy individuals, as well as in individuals with heart failure or post-myocardial infarction, ketones provide a supplemental energy source for both the heart and the vasculature.
Gary D. Lopaschuk, Jason R. B. Dyck
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Hypothyroidism and cardiovascular system
Clinical Medicine (Russian Journal), 2016The article presents data on the relationship between thyroid dysfunction and cardiovascular diseases. The role of dyslipidemia, adipokines (adiponectin, leptin, resistin), C-reactive protein, deficiency of vitamin D3 in the development of cardiovascular disease in hypothyroidism is discussed.
A F, Verbovoy +4 more
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MicroRNAs in the cardiovascular system
Current Opinion in Cardiology, 2011Reprogramming of gene expression underlies the mechanisms involved in cardiac pathogenesis. MicroRNAs (miRNAs) are unique posttranscriptional regulators of gene expression whose function in cardiac development and disease has recently begun to unravel. In addition, they are potentially highly effective therapeutic tools.
Mingyue, Han +2 more
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Age and the Cardiovascular System
New England Journal of Medicine, 1992DESPITE the decline in rates of mortality due to heart disease during the past two decades, cardiovascular disease remains the most frequent single cause of death among persons over 65 years of age.1 2 3 It also accounts for a major and growing proportion of hospitalizations and health care costs and is a leading cause of morbidity among older people.2
Franklin H. Epstein, Jeanne Y. Wei
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Exercise and the Cardiovascular System
The Physician and Sportsmedicine, 1979Whether regular endurance exercise will increase life span has not been conclusively proved, but as one panelist says, 'If you want to take a gamble, it's a good one.'
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Ghrelin and the Cardiovascular System
2014Ghrelin is a peptide that was originally isolated from the stomach. It exerts potent growth hormone (GH)-releasing and orexigenic activities. Several studies have highlighted the therapeutic benefits of ghrelin for the treatment of cardiovascular disease. In animal models of chronic heart failure, the administration of ghrelin improved cardiac function
Takeshi, Tokudome +3 more
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Osteopontin and cardiovascular system
Molecular and Cellular Biochemistry, 2006A matricellular protein, osteopontin (OPN), is expressed in response to mechanical stress and similar stimuli in the heart, integrates the inter-ECM signal transduction network of component cells, and maintains efficient contractility through quantitative and qualitative control of extracellular matrix (ECM) proteins. In particular, OPN is re-expressed
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Age and the cardiovascular system
Hospital Medicine, 1999Congestive heart failure is a common cause of morbidity and mortality in the elderly population. Important changes occur in the structure and function of the cardiovascular system with advancing age. An understanding of these changes is vital for optimum management of these patients.
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Aquaporins in Cardiovascular System
2017Recent studies have shown that some aquaporins (AQPs ), including AQP1, AQP4, AQP7 and AQP9, are expressed in endothelial cells, vascular smooth muscle cells and heart of cardiovascular system. These AQPs are involved in the cardiovascular function and in pathological process of related diseases, such as cerebral ischemia , congestion heart failure ...
Lu, Tie +3 more
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Arrestins in the Cardiovascular System
2013Of the four mammalian arrestins, only the β-arrestins (βarrs; Arrestin2 and -3) are expressed throughout the cardiovascular system, where they regulate, as either desensitizers/internalizers or signal transducers, several G-protein-coupled receptors (GPCRs) critical for cardiovascular homeostasis.
Anastasios, Lymperopoulos +1 more
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