Results 61 to 70 of about 20,387,570 (303)

Lysyl oxidase (LOX)‐mediated remodeling of the extracellular matrix

FEBS Letters, EarlyView.
The lysyl oxidase (LOX) family of enzymes drives extracellular matrix remodeling by oxidizing collagen, elastin, and fibronectin, promoting covalent cross‐link formation. This activity regulates tissue architecture and mechanical properties, while its dysregulation contributes to fibrosis, cardiovascular disease, glaucoma, connective tissue disorders ...
Fernando Rodríguez‐Pascual, Marta Navarro‐Gutiérrez, Verónica Romero‐Albillo, Raquel Jiménez‐Sánchez   +3 more
wiley   +1 more source

Optical coherence tomography-based machine learning for predicting fractional flow reserve in intermediate coronary stenosis: a feasibility study

Scientific Reports, 2020
Machine learning approaches using intravascular optical coherence tomography (OCT) to predict fractional flow reserve (FFR) have not been investigated.
Jung-Joon Cha, Tran Dinh Son, Jinyong Ha, Jung-Sun Kim, Sung-Jin Hong, Chul-Min Ahn, Byeong-Keuk Kim, Young-Guk Ko, Donghoon Choi, Myeong-Ki Hong, Yangsoo Jang   +10 more
doaj   +1 more source

Lessons from the post-genomic era: Globin diversity beyond oxygen binding and transport

Redox Biology, 2020
Vertebrate hemoglobin (Hb) and myoglobin (Mb) were among the first proteins whose structures and sequences were determined over 50 years ago. In the subsequent pregenomic period, numerous related proteins came to light in plants, invertebrates and ...
Anna Keppner, Darko Maric, Miguel Correia, Teng Wei Koay, Ilaria M.C. Orlando, Serge N. Vinogradov, David Hoogewijs   +6 more
doaj   +1 more source

Autophagy in the cardiovascular system [PDF]

Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 2009
Autophagy is a catabolic pathway for bulk turnover of long-lived proteins and organelles via lysosomal degradation. Growing evidence reveals that autophagy is involved in the progression or prevention of many human diseases. Here we discuss the role of autophagy in the normal heart, in heart disease and atherosclerosis.
De Meyer, Guido R.Y., Martinet, Wim
openaire   +2 more sources

Neutralization of the PTX3/CD44 axis suppresses TGF‐β1 signaling in kidney fibrosis

FEBS Letters, EarlyView.
This study investigates how the PTX3/CD44 axis promotes kidney fibrosis by activating TGF‐β1 signaling. We demonstrate that the neutralizing antibody WHC‐001 effectively inhibits this pathway, suppressing myofibroblast activation and partial epithelial–mesenchymal transition (EMT).
Chao‐Chun Cheng, Shen‐Shin Chang, Feng‐Wei Chen, Ying‐Chieh Su, Thanh Phuong Nguyen, Yu‐Wei Hsiao, Jhih‐Ying Chi, Hsin‐Yin Liang, Ju‐Ming Wang   +8 more
wiley   +1 more source

Update of the European Association of Cardiovascular Imaging (EACVI) Core Syllabus for the European Cardiovascular Magnetic Resonance Certification Exam. [PDF]

, 2014
An updated version of the European Association of Cardiovascular Imaging (EACVI) Core Syllabus for the European Cardiovascular Magnetic Resonance (CMR) Certification Exam is now available online. The syllabus lists key elements of knowledge in CMR.
Westwood, Mark, Karamitsos, Theodoros T.D., Cosyns, B, Alpendurada, Francisco, Petersen, Steffen Ellebæk, Petersen, SE, Greil, Gerald F., Stefanidis, Alexandros A.S., Bucciarelli-Ducci, C, Karamitsos, TD, Greil, Gerald Franz, Cosyns, Bernard, Lancellotti, Patrizio, Tann, Oliver, Petersen, Steffen E., Stefanidis, Alexandros, Boubertakh, Redha, Karamitsos, Theodoros D., Stefanidis, Alexandros S, Imaging, EAC, Almeida, Ana Gomes, Stefanidis, Alexandros S., Karamitsos, Theodoros D, Stefanidis, AS, Plein, S, Greil, Gerald, Bucciarelli-Ducci, Chiara, Greil, Gerald F, Boubertakh, R, Karamitsos, Theodoros, Westwood, M, Alpendurada, F, ?, ?, Almeida, Ana G, Lancellotti, P, Plein, Sven, Almeida, AG, Greil, GF, Almeida, Ana G., Petersen, Steffen E, Tann, O, Chirinos Medina, Julio, Marwick, Thomas H., Segers, Patrick, Galderisi, Maurizio, Derumeaux, Genevieve, Zamorano, Jose L., Haluska, Brian, Aurigemma, Gerard, Gillebert, Thierry, Tapp, Robyn J., Gottdiener, John, Ofili, Elizabeth, Senior, Roxy   +53 more
core   +1 more source

Gut microbiota alterations in patients with non‐small‐cell lung cancer undergoing chemoradiotherapy

Molecular Oncology, EarlyView.
We investigated the impact of concurrent chemoradiotherapy (CRT) on the gut microbiota in patients with locally advanced non‐small‐cell lung cancer. Overall gut microbiota composition remained largely stable throughout CRT while antibiotic exposure may influence microbial diversity.
Hanne Marte Nymoen, Zhi Zhao, Henrik Horndalsveen, Maria Moksnes Bjaanæs, Bjørn Henning Grønberg, Tarje Halvorsen, Tesfaye Madebo, Marianne Aanerud, Jussi Koivunen, Kersti Oselin, Saulius Cicenas, Nina Helbekkmo, Jarkko Ahvonen, Maria Silvoniemi, Tine Norman Alver, Tonje Dalen, Åsa Kristina Öjlert, Saima Jamil Farooqi, Åslaug Helland, Vilde Drageset Haakensen   +19 more
wiley   +1 more source

High Risk Coronary Atherectomy, Perforation, and Successful Percutaneous Treatment

JACC: Case Reports, 2020
We report a case of coronary perforation during high-risk percutaneous coronary intervention with Impella (Abiomed, Danvers, Massachusetts) support that resulted in cessation of pulsatile arterial flow. Maintenance of systemic perfusion due to antecedent
Graham Peigh, MD, Arif Jivan, MD, PhD, Ethan Kosova, MD, Aubrey Opyt, BSN, RN, Daniel Schimmel, MD, MS, Mark J. Ricciardi, MD   +5 more
doaj   +1 more source

Decision support system for cardiovascular problems [PDF]

, 2008
The DISHEART project aims at developing a new computer based decision support system (DSS) integrating medical image data, modelling, simulation, computational Grid technologies and artificial intelligence methods for assisting clinical diagnosis and ...
Soudah Prieto, Eduardo, Oñate Ibáñez de Navarra, Eugenio, Bordone, Maurizio, López González, Roberto   +3 more
core  

Extracellular matrix remodeling and immune reprogramming drive residual tumor progression of liver cancer after incomplete microwave ablation

Molecular Oncology, EarlyView.
Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu, Yubei He, Nikolaus Berndt, Michael Mülleder, Kathrin Textoris‐Taube, Jing Guo, Matthias Stechele, Justus Ramtke, Shraga Nahum Goldberg, Lynn Jeanette Savic   +9 more
wiley   +1 more source