Results 61 to 70 of about 1,451,116 (316)

Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum

FEBS Open Bio, EarlyView.
Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik, Russell Pickford, Hannah C. Timmins, Olivier Piguet, Glenda M. Halliday, Matthew C. Kiernan, Woojin Scott Kim   +6 more
wiley   +1 more source

Cardiovascular pathology: guide to practice and training [PDF]

, 2022
This chapter addresses the scope of practice and training in cardiovascular pathology. The importance of the autopsy for the documentation of cardiovascular diseases is discussed, including expanding roles for diagnostic imaging and molecular and genetic
Lelenwa, L., Zhao, B., Segura, A., Michaud, K., Buja, LM, McDonald, M.   +5 more
core   +1 more source

Timely Management of Obstructive Prosthetic Valve Thrombosis

JACC: Case Reports, 2019
Obstructive bioprosthetic valve thrombosis is associated with hemodynamic compromise, and evidence on management with fibrinolysis is limited. Echocardiography is required to assess thrombus size and its effects on valve gradients, area, and leaflet ...
Elona Rrapo Kaso, MD, Steve A. Noutong, MD, LeAnn N. Denlinger, MD, Mohammed Morsy, MD, Christopher M. Kramer, MD   +4 more
doaj   +1 more source

Acute Myocardial Infarction With Cardiogenic Shock Due to Pericardial Constriction and Multivessel Coronary Obstruction

JACC: Case Reports, 2020
We present a rare case of cardiogenic shock and multivessel coronary compression due to focal pericardial inflammation and constriction. The patient was treated in the acute phase with coronary stenting and temporary mechanical support.
Matthew F. Schaikewitz, MD, Christopher B. Nnaoma, MD, Richard D. Meredith, MD, Seth Uretsky, MD, Lawrence R. Blitz, MD, Allan L. Klein, MD, Mark S. Rosenthal, MD   +6 more
doaj   +1 more source

Physician-modified aortic cuff to “stabilize” paravisceral aortic thrombus and minimize risk of distal embolization during pararenal aneurysm repair with fenestrated stent graft

Journal of Vascular Surgery Cases and Innovative Techniques, 2022
As technology and surgeon experience evolve, endovascular repair of complex abdominal aortic aneurysms is often preferred in appropriately selected patients. However, the presence of pedunculated aortic thrombus represents a relative contraindication for
Brandon Douglass, MD, Tiziano Tallarita, MD, Jason Beckermann, MD, Vinay Nijhawan, MD, Joseph Wildenberg, MD, PhD, Jeremy McBride, MD, Thomas Carmody, MD   +6 more
doaj   +1 more source

PPARs and the Cardiovascular System

Antioxidants & Redox Signaling, 2009
Peroxisome proliferator-activated receptors (PPARs) belong to the nuclear hormone-receptor superfamily. Originally cloned in 1990, PPARs were found to be mediators of pharmacologic agents that induce hepatocyte peroxisome proliferation. PPARs also are expressed in cells of the cardiovascular system.
Hamblin, Milton, Chang, Lin, Fan, Yanbo, Zhang, Jifeng, Chen, Y. Eugene   +4 more
openaire   +4 more sources

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

FEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer, Angelique Kragl, Katrin Ziems, Juliane Glaubitz, Sophie Grammbauer, Susanne Hildebrandt, Mladen V. Tzvetkov, Gabriele Jedlitschky   +7 more
wiley   +1 more source

Hemostatic efficacy of a flowable collagen-thrombin matrix during coronary artery bypass grafting: a double-blind randomized controlled trial

Journal of Cardiothoracic Surgery, 2023
Background Flowable hemostatic agents have the advantage of being able to be applied to irregular wound surfaces and difficult to reach areas. We sought to compare the effectiveness and safety of the flowable hemostatic sealants Collastat® (collagen ...
Hyo-Hyun Kim, Kang Ju Lee, Dae Ryong Kang, Jun Hyeok Lee, Young-Nam Youn   +4 more
doaj   +1 more source

Cyclic azapeptide CD36 ligand attenuates cardiac injury and reduces long‐chain fatty acid accumulation after myocardial ischemia–reperfusion in mice

FEBS Open Bio, EarlyView.
In a murine model of myocardial ischemia and reperfusion (MI/R), the CD36 azapeptide ligand MPE‐298 reduces cardiac injury and transiently lowers left ventricular long‐chain fatty acids (LCFAs) accumulation 3 h after reperfusion, accompanied by a decrease of oxidative stress and inflammation‐associated genes' expression in the heart and adipose tissue.
Jade Gauvin, Naghme Radmannia, David N. Huynh, Liliane Ménard, Caroline Daneault, Maïté Veilleux, Ahsanullah Ahsanullah, André C. Carpentier, William D. Lubell, Matthieu Ruiz, Huy Ong, Sylvie Marleau, Simon‐Pierre Gravel   +12 more
wiley   +1 more source

Essential Roles of PIEZO1 in Mammalian Cardiovascular System: From Development to Diseases [PDF]

Mechanical force is the basis of cardiovascular development, homeostasis, and diseases. The perception and response of mechanical force by the cardiovascular system are crucial.
Sheng’an Su, Kaijie Chen, Yue Zhang, Hong Ma, Chengjiang Jin, Shuo Yu, Meixiang Xiang   +6 more
core   +1 more source