Results 161 to 170 of about 7,992,081 (314)

Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

Molecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski, Liudmyla Dolinchuk, Michał Jerzak, Albert Gandurski, Tomasz Grochowski, Weronika Wojtyś, Maciej Zadrożny, Wojciech Kaźmierczak, Małgorzata Lenarcik, Marta Matejak‐Górska, Radosław Samsel, Tomasz Olesiński, Dawid Walerych   +12 more
wiley   +1 more source

PEN-Plus: a first step to better care

The Lancet Primary Care
The Lancet Primary Care
doaj   +1 more source

Taking care of women entrepreneurs in deprived areas ? Supporting business in Politique de la ville

GéoProximitéS
When women’s entrepreneurship is receiving political support from international to local scale, some associations are helping women to set up their own business in disadvantaged neighbourhoods. Entrepreneurship advisors seek to strengthen their capacity
Lorena Clément
doaj  

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

La double invisibilisation du care réalisé par les femmes en situation de post-catastrophe climatique : l’exemple de la vallée de la Roya.

GéoProximitéS
Following situations referred to as natural disaster (caused or not by humans), the concept of care (Tronto, 2008, 2012) is concrete because care activities become the main concern of everyone in order to ensure the vital needs of populations and of ...
Anouk Migeon
doaj  

Evaluating the structure and process of effective integrated care for people with multiple long-term conditions: systematic review protocol. [PDF]

BMJ Open
Todowede O, Damery S, Dracup N, Donoghue J, Butt F, Grove A, Scantlebury A.   +6 more
europepmc   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Perinatal interventions for parents with exposure to adverse childhood experiences: A narrative review of suitability for implementation in primary care. [PDF]

Infant Ment Health J
Chen JJ, Magnuson K, Edgar VB, Stewart SM.   +3 more
europepmc   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Environmental Sustainability Profile of Intensive Care Nurses in Türkiye: A Cross-Sectional Study. [PDF]

Nurs Crit Care
Erdem T, Yildiz Ayvaz M, Karadağ Aytemiz ÖE, Turen S, Ateş S, Bulbul E, Çetin E.   +6 more
europepmc   +1 more source