Results 101 to 110 of about 5,900,632 (304)
Patient Preference and AdherenceYing Zhang,1 Mingyuan Liu,2 Jing Han,3 Xin Tian,4 Youqing Xin5 1School of Public Health, Capital Medical University, Beijing, 100069, People’s Republic of China; 2Department of Vascular Surgery, Beijing Friendship Hospital, Capital Medical University ...
Zhang Y, Liu M, Han J, Tian X, Xin Y
doaj
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
, 2017 Xia Wang,1 Qiongni Chen,2 Min Yang1 1Xiangya School of Nursing, 2Nursing Department, Second Xiangya Hospital, Central South University, Changsha, Hunan, People’s Republic of China Background: This study assessed the effect of expressed emotion ...
Chen Q, Yang M, Wang X
core
Open MedicineFamily caregiving for dementia patients is a challenging task, with profound effects on caregivers’ physical and mental well-being. The purpose of this study was to explore the impact of Kolb’s experiential learning theory on the caregiving burden and ...
Xu Yue +3 more
doaj +1 more source
FEBS Letters, EarlyView.Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante +10 more
wiley +1 more source
Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding
FEBS Letters, EarlyView.In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança +2 more
wiley +1 more source
The hidden economic burden of cancer caring
CancerAbstractBackgroundAdvances in clinical cancer care have increased the number of survivors, which has impacted informal caregiving. This study estimates the annual opportunity cost of informal cancer care and quantifies the gap in the quality adjusted life expectancy (QALE).MethodInformal cancer carers by sex and two age groups (15–64 years old and 65 ...
Lan Gao +12 more
openaire +2 more sources
FEBS Letters, EarlyView.Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell +2 more
wiley +1 more source
, 2012 [[abstract]]Background: To cope with social problems raised by aging population, the Government had promoted the “Ten-year Program for Long-Term Care” as well as other programs since 1998.
Chuang, Wen Ling
core
FEBS Letters, EarlyView.How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley +1 more source