Results 121 to 130 of about 5,900,632 (304)

The Role of Resilience in Predicting the Care Burden of Family Caregivers of Stroke Patients: Descriptive Cross-Sectional Study [PDF]

نشریه پرستاری ایران
Background & Aims The family caregivers of stroke patients experience a high care burden that has negative effects on their lives. Resilience is a factor that seems to be able to help them adapt to these conditions.
Sajjad Amiri Bonyad, Faezeh Shamlou Hasani, Arezou Karampourian, Behnaz Alafchi   +3 more
doaj  

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Social alienation and influencing factors among caregivers of stroke patients in China: a cross-sectional study

Frontiers in Psychiatry
IntroductionAs the primary bearers of post-stroke rehabilitation and long-term care, caregivers of stroke patients in China face a profound sense of social alienation that has not yet been fully recognized due to issues such as role-related limitations ...
Lang Xu, Lang Xu, Lang Xu, Shanshan Liu, Mao Luo, Min Li, Cong Wang, Cong Wang   +7 more
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Prelude to 220 or 110

, 1971
[Burden] lay bolted with copper bands to a concrete floor, near two buckets of water in which live 110-volt lines had been submerged. Had anyone visiting the gallery chosen to spill the water, Burden would have been electrocuted.
Burden, Chris
core  

Australian burden of disease study: fatal burden of disease in Aboriginal and Torres Strait Islander people 2010 [PDF]

, 2015
This report presents estimates of fatal burden for Aboriginal and Torres Strait Islander Australians for 2010. Estimates of the \u27gap\u27 in fatal burden between Indigenous and non-Indigenous Australians are also reported, together with selected sub ...
Australian Institute of Health and Welfare
core  

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Nurses’ Burden of Elimination Care: Sequential Explanatory Mixed-Methods Design

, 2023
Se Young Jung,1,2 Hui-Woun Moon,2 Da Som Me Park,2 Sumi Sung,3 Hyesil Jung4 1Department of Family Medicine, Seoul National University Bundang Hospital, Seongnam, Republic of Korea; 2Office of eHealth Research and Business, Seoul National University ...
Jung SY, Moon HW, Jung H, Sung S, Park DSM   +4 more
core  

Maternal care burdens

Summary Malnutrition remains the primary cause of child mortality in Eastern Ethiopia. This thesis examines the persistent impact of child malnutrition on mortality rates despite widespread public awareness and ongoing governmental interventions.
openaire   +2 more sources