Results 101 to 110 of about 5,997,028 (302)

International accreditation for acute stroke care: lessons learnt from a Kenyan Stroke Centre

open access: yesFrontiers in Stroke
BackgroundThe prevalence of stroke is increasing in Africa, yet resources remain limited in managing the disease. Whilst there are international guidelines on how to set up and manage stroke services, even in resource-limited settings, the uptake remains
Dilraj Singh Sokhi
doaj   +1 more source

Interprofessional Pulmocheck care pathway: An innovative approach to managing pediatric asthma care in the Netherlands

open access: yes, 2018
Objectives: Under-diagnosis and suboptimal asthma control in children persists. An innovative care pathway was developed by a hospital department of pediatrics with the aim to detect pulmonary problems in children and provide appropriate treatment ...
Dauven, T.   +8 more
core   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

open access: yesMolecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington   +10 more
wiley   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

open access: yesMolecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq   +8 more
wiley   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

open access: yesMolecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park   +6 more
wiley   +1 more source

Kansas Health Care Stabilization Fund General Information [2014]

open access: yes, 2014
"As of July 1, 2014." "The above information is updated based on enactment of 2014 House Bill 2516. Fund or HCSF means the Health Care Stabilization Fund. Fund law means the Health Care Provider Insurance Availability Act (K.S.A.
Kansas. Health Care Stabilization Fund.
core   +1 more source

Online Supports for Family Carers: Options & Experiences [PDF]

open access: yes, 2016
One of the key developments of the late 20th and early 21st centuries is the development of the internet as an everyday tool used by the majority of citizens.
Care Alliance Ireland
core  

Reablement training and practice : challenging ageism, ableism, and dependency in the care of older Australians

open access: yes, 2023
How can formal care arrangements and procedures using reablement practices of ‘working with’ older people, challenge the stigma of ‘dependency’ in the care of older adults?
Maxwell, Hazel (R20947), Linden, Tanya
core  

Cancer‐associated mutations in endometriosis reframe a benign disease through molecular oncology

open access: yesMolecular Oncology, EarlyView.
This review aims to comprehensively analyse cancer‐associated somatic mutations (CAMs) present in endometriotic lesions, emphasizing their biological roles, spatial distribution and implications for translational applications in medicine. By contextualizing a benign state within a genomic framework, this analysis seeks to establish its value as a ...
Clarissa Mujacic   +15 more
wiley   +1 more source

Disability and family carer policy - challenges and responses [PDF]

open access: yes, 2017
A working definition of ‘disability’ is crucial to any research, policy development or service provision in the field. There are many definitions of disability (Iezzoni & Freedman, 2008), some directly contradicting others. These differences originate
Care Alliance Ireland
core  

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