Results 71 to 80 of about 853,686 (274)
FEBS Letters, EarlyView.This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee +2 more
wiley +1 more source
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
Frontiers in Organizational PsychologyIntroductionThis study examines the role of identity leadership in shaping employees' career calling and work-related attitudes across cultural contexts. Drawing on the Social Identity Approach and research on calling, we propose a serial mediation model
Mahtab Fardi +3 more
doaj +1 more source
FEBS Letters, EarlyView.How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley +1 more source
A Comprehensive Study on Career Calling: Understanding the Role of Socioeconomic Factors and Work Volition Across Cultures [PDF]
openWork as a calling has been present in many different cultures and traditions throughout history, offering both positive and potential challenges. Understanding the concepts associated with career calling becomes pivotal for improving the experience ...
COSKUN, PELIN
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The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation
FEBS Letters, EarlyView.Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge +6 more
wiley +1 more source
The Development, Validation, and Application of a Career Calling Scale for Emerging Adults: Examining the Role of Career Calling in Career Development [PDF]
, 2014 This PhD research program aimed to fulfil three objectives: (1) develop a new measure to assess career calling in emerging adulthood, (2) apply a general goal-setting model to test cross-sectional associations between career calling, self-regulatory ...
Praskova, Anna
core +1 more source
Chiral separation of chloroalkanes with the chromatographic column onboard Martian rovers
FEBS Letters, EarlyView.Computer image of the Rosalind Franklin Rover of ESA's ExoMars mission. ExoMars is scheduled to land on planet Mars in Oxia Planum in 2029. This area represents an interesting spot to look for biosignatures. Investigations of ExoMars include measurement on molecular chirality. We show that chiral chloroalkanes, that have been identified on Mars, can be
Asma Merzougui +4 more
wiley +1 more source
Prospecting the protein design landscape
FEBS Letters, EarlyView.This review outlines the current state of various protein design approaches. We discuss the current possibilities enabled by recently released tools, highlight future avenues to pursue in protein design, and underscore the crucial role of key databases and resources for successful protein design workflows.
Jakob R. Riccabona +4 more
wiley +1 more source
Is the Concept of Calling still Relevant to Career Decision Making in Norway? Validating the Calling and Vocation Questionnaire (CVQ) with Norwegian Career Counsellors [PDF]
The concept of calling has been developed to recognise that much career decision making does not follow a rational model. Many people feel ‘called’ to an occupation in a way that transcends an analysis of capabilities and opportunities.
Hanson, J. +3 more
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