Results 71 to 80 of about 2,576,113 (332)
FEBS Letters, EarlyView.This study reveals how prime editing guide RNA (pegRNA) secondary structure and reverse transcriptase template length affect prime editing efficiency in correcting the phospholamban R14del cardiomyopathy‐associated mutation. Insights support the design of structurally optimized enhanced pegRNAs for precise gene therapy.
Bing Yao +7 more
wiley +1 more source
Personality and career choices
AFRICAN JOURNAL OF BUSINESS MANAGEMENT, 2012 Personality has been viewed as source of person’s attitude exhibited on the job workplace over the years. In this paper, propositions have been made about different kind of personality traits having relevance with nature of job requirements. The study tried to argue that prominent feature of personality traits can be successful in aligning with the ...
Sajjad Hussain +3 more
openaire +3 more sources
The Influence of Generations On Career Choice (Social Cognitive Career Theory Perspective)
, 2018 The aim of this study is to investigate the influence of generations on career choice based on Social Cognitive Career Theory (SCCT). Our literature studies conclude that individual’s career choice will be highly related to the major characteristics and ...
Galuh Prawitasari
semanticscholar +1 more source
Cyclic nucleotide signaling as a drug target in retinitis pigmentosa
FEBS Letters, EarlyView.Disruptions in cGMP and cAMP signaling can contribute to retinal dysfunction and photoreceptor loss in retinitis pigmentosa. This perspective examines the mechanisms and evaluates emerging evidence on targeting these pathways as a potential therapeutic strategy to slow or prevent retinal degeneration.
Katri Vainionpää +2 more
wiley +1 more source
FEBS Letters, EarlyView.Three‐dimensional (3D) biological systems have become key tools in lymphoma research, offering reliable in vitro and ex vivo platforms to explore pathogenesis and support precision medicine. This review highlights current 3D non‐Hodgkin lymphoma models, detailing their features, advantages, and limitations, and provides a broad perspective on future ...
Carla Faria +3 more
wiley +1 more source
Guidance methods in psychological «spaces» of self-determination [PDF]
Национальный психологический журнал, 2017 Self-determination is deemed as search and continuous refinement of the meaning of the future life. The paper discusses various options for self-determination, i.e. professional, personal, social, and other ones. Self-determination means making a certain
Nikolai S. Prjazhnikov
doaj +1 more source
FEBS Letters, EarlyView.Tuberculosis remains a global health challenge and new therapeutic targets are required. Here, we characterized SseA, a sulfurtransferase from Mycobacterium tuberculosis involved in macrophage infection, and its interaction with the newly identified protein SufEMtb that activates SseA enzymatic activity.
Giulia Di Napoli +10 more
wiley +1 more source
Frontiers in EducationIntroductionGuided by the Factors Influencing Teaching Choice (FIT-Choice) model, this study investigates the career choices of student teachers majoring in childcare and analyses the factors influencing their career choices to address the teacher ...
Xinghua Wang +5 more
doaj +1 more source
CMAJ Open, 2016 BACKGROUND Specialty career choice is a critical decision for medical students, and research has examined factors influencing particular specialties or assessed it from a demographic perspective.
K. Pianosi, C. Bethune, K. Hurley
semanticscholar +1 more source
Development of visible light‐sensitive human neuropsin (OPN5) via single amino acid substitution
FEBS Letters, EarlyView.The present study determines a key amino acid residue, Lys91, for defining UV sensitivity of human OPN5. Heterologous action spectroscopy of the wild type and K91 mutants of OPN5 in HEK293T cells reveals that substitution of Lys91 with neutral (alanine) or acidic amino acids (glutamic or aspartic acids) causes substantial shifts in spectral sensitivity
Yusuke Sakai +2 more
wiley +1 more source