Results 61 to 70 of about 30,651 (306)

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Web-enhanced return-to-work coordination for employees with common mental disorders: reduction of sick leave duration and relapse

BMC Public Health
Background Common mental disorders (CMDs) are highly prevalent in workplace settings, and have become a significant public health challenge. This study aims to assess the effectiveness of PRATICAdr, a web application facilitated by a Return-to-Work ...
Marc Corbière, Maud Mazaniello-Chézol, Tania Lecomte, Stéphane Guay, Alexandra Panaccio, Charles-Édouard Giguère   +5 more
doaj   +1 more source

Guiding AlphaFold to predict how Munc13‐1 opens Syntaxin‐1

FEBS Open Bio, EarlyView.
The syntaxin‐1 Habc‐domain (orange), linker (pink) and SNARE motif (yellow) form a closed conformation that binds to Munc18‐1 (violet) and is opened by the Munc13‐1 MUN domain (cyan) to form the SNARE complex that triggers neurotransmitter release.
Madhurima Chattopadhyay, Junjie Xu, Josep Rizo   +2 more
wiley   +1 more source

Empowering career pathways: integrating self-regulation strategies with career counseling practices

Frontiers in Education
IntroductionThis study explores the integration of self-regulation strategies into career counseling to enhance career development. It outlines the rationale behind this integration and sets the objectives of providing practical strategies for educators ...
Mohsen Rezaiee, Hossein Kareshki
doaj   +1 more source

Family Therapy; An Approach To Strengthen Islamic Career Counseling

Konseling Religi: Jurnal Bimbingan Konseling Islam, 2019
Research on families, especially parents, both the role and parenting style in the household, are not counted. However, problems that arise and originate from the family sphere come alternately.
Alfin Miftahul Khairi
doaj   +1 more source

Transcripts enriched in codons that trigger P‐site tRNA‐mediated mRNA decay possess stable mRNA

FEBS Open Bio, EarlyView.
PTMD codons were first described by Mendel et al. as mediators of an mRNA decay pathway dependent on the human protein CNOT3, homologous to yeast Not5. Our findings confirm that PTMD codons destabilize transcripts; however, unlike in yeast, the human pathway specifically targets and slightly destabilizes primarily stable mRNAs.
Rodolfo Lopes Carneiro, Fernando Lucas Palhano   +1 more
wiley   +1 more source

Role induction in career counseling

, 2011
[[abstract]]Many vocational psychologists advocate addressing career as well as personal concerns in career counseling. However, some clients may have inappropriate expectations toward career counseling and may not be prepared or want to discuss personal
Fouad, Nadya A.;Chen, Yung-Lung;Guillen, Amy;Henry, Caroline;Kantamneni, Neeta;Novakovic, Alexandra;Priester, Paul E.;Terry, Sarah
core  

Comparison of the efficacy of acceptance and commitment counseling (ACT) and constructivism-based counseling in orientation career protean of contract staff

مجله علوم روانشناختی, 2022
Background: In a world where the phenomenon of job loss is spreading rapidly, it is essential to be willing to invest continuously in a diverse career path that will lead to savings in human, social and psychological capital.
abed majidi, mohammad reza abedi, fatemeh samiee, parisa nilforooshan   +3 more
doaj  

Pathways and pitfalls: a qualitative study of student experiences in biomedical science education

FEBS Open Bio, EarlyView.
Biomedical science students from underrepresented backgrounds face barriers including financial strain, disrupted laboratory access and cultural exclusion. Peer networks provide vital support when institutional systems are difficult to navigate. To create inclusive learning environments and achieve academic success, educators should blend active, hands‐
Olivia J. Russell, Cassy Ross, Panagiota S. Filippou, Bruno Silvester Lopes, Dominic Gilchrist, Paul Dean, Kamar Ameen‐Ali, Tora K. Smulders‐Srinivasan, Ahmad A. Khundakar   +8 more
wiley   +1 more source

Re‐Awakening Public Attention to the Silent Pandemic of Cancer Among Older Adults in Low‐ and Middle‐Income Countries

Aging and Cancer, EarlyView.
ABSTRACT As global populations age, cancer is increasingly becoming a leading cause of morbidity and mortality among older adults, particularly in low‐ and middle‐income countries (LMICs). Despite accounting for the majority of new cancer cases and deaths, older individuals remain underrepresented in cancer research, clinical guidelines, and health ...
Ibrahim Bidemi Abdullateef, Sunkanmi Folorunsho, Abdulazeez Opeyemi Abdulganiyu   +2 more
wiley   +1 more source