Results 71 to 80 of about 140,915 (300)
Molecular Oncology, EarlyView.CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir +12 more
wiley +1 more source
Promoting healthy transition from college to work market throughout seminars: the building of the therapeutic relationship [PDF]
, 2009 This communication presents a specialized preventive career intervention – the Career Self-Management Seminar (CSMS; Taveira et al., 2006 – forms A and B).
Loureiro, Nazaré +2 more
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Online career construction for a trauma survivor with career choice ambivalence
South African Journal of Higher EducationThis article reports on the online administration of career construction counselling for a trauma survivor who sought help in resolving her career-choice ambivalence (uncertainty). The participant was purposively selected from a group of people attending
J. G. Maree
doaj +1 more source
The Relationship Between Career Patterns And Personality Types
SA Journal of Industrial Psychology, 2002 Contemporary career research emphasises the need for career counselling practices that will assist individuals in shifting from linear career preferences to non-linear career patterns.
M. Coetzee, A. M.G. Schreuder
doaj +1 more source
Molecular Oncology, EarlyView.Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz +15 more
wiley +1 more source
Kariérové cesty intelektovo nadaných ľudí
Psychologie pro Praxi, 2019 In comparison with other areas of lives of intellectually gifted, their career development is relatively rarely discussed and researched. In this overview study specific problems that gifted students face when choosing their careers (such as ...
Eva Rajčániová
doaj +1 more source
Life-design counselling for survivors of family violence in resource-constrained areas
South African Journal of Education, 2020 The purpose of this study was to explore and assess the feasibility of counselling based on life-design principles in enhancing the career resilience of children who are exposed to family violence. The research project involved a QUALITATIVE–quantitative
Cobus J. Venter , Jacobus G. Maree
doaj +1 more source
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Workplace Counselling in Indonesia [PDF]
, 2003 Workplace counselling is aimed at providing support for the physical and mental welfare of employees. This effort will have impact on increasing productivitiy and work performance of employees so that as the end result the company will get a better ...
Mawardi, Artiawati +1 more
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Effect of chemotherapy on passenger mutations in metastatic colorectal cancer
Molecular Oncology, EarlyView.Changes in passenger mutation load and predicted immunotherapy response after chemotherapy treatment. Tumor cells rich with passenger mutations have increased sensitivity to chemotherapy. Correlation of passenger mutations with neoantigen load suggests highly mutated clones promote a more effective response to immunotherapy, and therefore, first‐line ...
Marium T. Siddiqui +6 more
wiley +1 more source