Results 71 to 80 of about 797,424 (256)

Narrative Career Counselling and People with Refugee Backgrounds

open access: yes
This chapter explores the application of narrative career counselling to support the career development of people with refugee backgrounds after resettlement.
Abkhezr, Peyman
core   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

open access: yesMolecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur   +11 more
wiley   +1 more source

The Relationship Between Career Patterns And Personality Types

open access: yesSA Journal of Industrial Psychology, 2002
Contemporary career research emphasises the need for career counselling practices that will assist individuals in shifting from linear career preferences to non-linear career patterns.
M. Coetzee, A. M.G. Schreuder
doaj   +1 more source

A Practitioner's Guide to Uncharted Waters of Career Counselling, a Critical Reflection Perspective

open access: yes, 2021
This is a practical book intended for career practitioners working with young people in schools and other institutions providing career guidance and counselling.
Graungaard, Elisabeth   +13 more
core  

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

open access: yesMolecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche   +10 more
wiley   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

open access: yesMolecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi   +6 more
wiley   +1 more source

Strengths and Weaknesses of the Polish System of Vocational Guidance and Career Counselling for Convicts on the Example of Occupational Activation Forms

open access: yesHoryzonty Wychowania, 2019
RESEARCH OBJECTIVE: The aim of the article is to present strengths and weaknesses of the Polish system of vocational guidance and career counselling for convicts on the example of occupational activation forms.
Daria Joanna Becker-Pestka
doaj  

Life-design counselling for survivors of family violence in resource-constrained areas

open access: yesSouth African Journal of Education, 2020
The purpose of this study was to explore and assess the feasibility of counselling based on life-design principles in enhancing the career resilience of children who are exposed to family violence. The research project involved a QUALITATIVE–quantitative
Cobus J. Venter , Jacobus G. Maree
doaj   +1 more source

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

open access: yesMolecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee   +3 more
wiley   +1 more source

Extracellular matrix remodeling and immune reprogramming drive residual tumor progression of liver cancer after incomplete microwave ablation

open access: yesMolecular Oncology, EarlyView.
Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu   +9 more
wiley   +1 more source

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