Results 61 to 70 of about 4,045,619 (295)

Factors that influence career uncertainty in college freshmen [PDF]

, 2003
Plan BCareer development is a lifelong process that can be fostered through education programs at all levels, but specifically during the beginning of one’s college years.
Sinz, Amber A.
core  

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Career Decision Ambiguity Tolerance and Career Decision-Making Difficulties in a French Sample: The Mediating Role of Career Decision Self-Efficacy [PDF]

Journal of Career Assessment, 2017
In the current work, we investigated the relationship between career decision ambiguity tolerance (CDAT) and career decision-making difficulties among French-speaking university students. In a preliminary validation study ( N = 246), we examined the psychometric properties of the CDAT Scale.
Storme, Martin, Celik, Pinar, Myszkowski, Nils   +2 more
openaire   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Self-efficacy source and career adaptability: The mediating roles of career decision self-efficacy

Humanitas: Indonesian Psychological Journal, 2019
Career adaptability is defined as individual’s ability to make self and environmental assessments in order to deal with changes that occur to themselves and the environment — both planned and unplanned.
Firosyana Rizki Amalia, Farida Kurniawati   +1 more
doaj   +1 more source

The Impact of a College Career Intervention Program on Career Decision Self-Efficacy, Career Indecision, and Decision-Making Difficulties [PDF]

Journal of Career Assessment, 2017
A quasi-experimental longitudinal intervention study utilizing intervention and comparison groups was carried out with first-year Malaysian college students in order to evaluate the effectiveness of a careers course designed to help students in their career decision-making. Participants in both groups were given questionnaires assessing career decision
Lam, Michele, Santos, Angeli
openaire   +1 more source

Waiting for a career epiphany - a barrier to decision-making? [PDF]

, 2018
The desire for a career epiphany, a sudden realisation of a future career, can often feature as an unspoken wish in career conversations with students and graduates.
Cunningham, E.A, Houston, K, Houston, Kathleen, Cunningham, EA   +3 more
core   +1 more source

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source