Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition
Molecular Oncology, EarlyView.We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff +11 more
wiley +1 more source
Deconstructing barriers to support Japanese students in group discussion
The Asia Pacific Scholar, 2022 Kiyotaka Yasui +6 more
doaj +1 more source
The Impact of Early Career Experiences on Youth’s Proactive Work Socialization Behavior [PDF]
, 1995 Little is known about the impact of individual characteristics, historical factors, and situational characteristics on youth\u27s proactive work socialization behavior (career planning, skill development, consultation, and networking).
Claes, Rita +1 more
core +2 more sources
Molecular Oncology, EarlyView.This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris +10 more
wiley +1 more source
Career Development – A Longitudinal Study Into Career Value Change [PDF]
Career theorists have long suggested that age and life stages have an impact upon our career values. However there is substantial disagreement over how this actually manifests itself. Some suggest these differences are generational with external factors
Arnold, J. +2 more
core
The characteristics of nurses in relation to their attitudes about career planning and development activities : a thesis presented in partial fulfillment of the requirements for the degree of Masters of Philosophy in Nursing at Massey University, Wellington, New Zealand [PDF]
, 2016 Introduction: The dilemma of nursing workforce capacity in coming years, as older nurses prepare to exit the workforce to retire, creates pressure on those that remain and makes retention of nurses a priority.
Bigsby, Margaret Anne
core
Targeting p38α in cancer: challenges, opportunities, and emerging strategies
Molecular Oncology, EarlyView.p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley +1 more source
Career Development Program for Refugee and Migrant Youth [PDF]
, 2006 The Career Guidance for Refugee and Migrant Young People project is an initiative of the South Metropolitan Migrant Resource Centre funded by the Department of Education and Training.
Gallegos, D., Tilbury, F.
core +1 more source
Careers Education: An Effective Tool for Poverty Reduction [PDF]
, 2008 Education plays an important role in enhancing the quality of life of people, both old and young. However, the quality of education someone receives per time determines the impact and contributions he or she makes in terms of poverty reduction, income ...
Moses, Chinonye, Love
core +1 more source