Results 101 to 110 of about 705,010 (250)

A mixed methods evaluation of a facilitated research career pathway for nurses, midwives, allied health professionals and healthcare scientists working in the NHS

BMC Medical Education
Background Opportunities for nurses, midwives, allied health professionals and healthcare scientists (NMAHP+s) to engage in research are increasing but still lag behind opportunities for medical staff.Iinitiatives to identify, support and develop NMAHP+s
Eleanor Lutman-White, Nicolas Aldridge, Ceri Jones, Agnieszka Lewko, Jane Coad   +4 more
doaj   +1 more source

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

Molecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico, Veronica La Banca, Silvia D'Amico, Stefano Scalera, Sara Nicolai, Angelo Peschiaroli   +5 more
wiley   +1 more source

Extracellular matrix remodeling and immune reprogramming drive residual tumor progression of liver cancer after incomplete microwave ablation

Molecular Oncology, EarlyView.
Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu, Yubei He, Nikolaus Berndt, Michael Mülleder, Kathrin Textoris‐Taube, Jing Guo, Matthias Stechele, Justus Ramtke, Shraga Nahum Goldberg, Lynn Jeanette Savic   +9 more
wiley   +1 more source

The enablers of early career outcomes of information technology professionals

, 2018
The sustainability of digital economies requires that IT prospects find employment, persist and succeed in IT careers. IT research have yet to examine the enablers of these salient early career outcomes.
Setor, Tenace Kwaku
core   +1 more source

Shaping the new normal : practicing career guidance in the time of Coronavirus [PDF]

, 2020
What is the potential of career guidance in a time where the coronavirus is disrupting work and life as we know it? How can we as career practitioners respond in a situation where we do not know what the world will look like and where we, as well as ...
Sultana, Ronald, Hooley, Tristram, Sultana, Ronald G., Thomsen, Rie   +3 more
core  

Spatial heterogeneity of hotspot mutations and clonal relatedness in ovarian endometrioid carcinoma

Molecular Oncology, EarlyView.
Spatially resolved analysis revealed heterogeneous distributions of selected cancer‐associated mutations within ovarian endometrioid carcinomas. Shared mutations between paired endometrial and ovarian tumors supported clonal relatedness. These findings highlight the value of sampling multiple tumor regions when interpreting molecular profiles ...
Takahito Ashihara, Kosuke Murakami, Shiro Takamatsu, Akiko Kanto, Seiichi Mori, Tomoyuki Otani, Kazuko Sakai, Yasushi Kotani, Kazuto Nishio, Kaoru Abiko, Noriomi Matsumura   +10 more
wiley   +1 more source

“What we see in the In-Between”: navigating ethics and equity in the role of leading research projects with Alaska Native communities

Arctic Science
As 13 leaders in research with Alaska Native communities, we came together in a workshop to self-define the role of boundary spanners within our cross-cultural contexts.
Margaret Rudolf, Eva Dawn Burk, Craig Chythlook, Lauren Mallory Berry Divine, Kaare Sikuaq Erickson, Janessa Esquible, Elizabeth Figus, Karli Tyance Hassell, Krista Heeringa, Adelheid Herrmann, Henry P. Huntington, Mellisa Maktuayaq Johnson, Harmony Wayner   +12 more
doaj   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source

Aquaporin‐3 and aquaporin‐5 impact the development of pancreatic ductal adenocarcinoma spheroids

FEBS Open Bio, EarlyView.
Schematic representation of the role of aquaporin‐3 (AQP3) and aquaporin‐5 (AQP5) in pancreatic ductal adenocarcinoma (PDAC). Both proteins are upregulated in PDAC and are associated with tumor progression and metastatic potential. Silencing AQP3 or AQP5 in PDAC spheroids results in decreased diameter, area, and overall growth, underscoring their key ...
Catarina Pimpão, Diogo M. Engrácia, Graça Soveral, Filipa Mendes   +3 more
wiley   +1 more source

How can we promote academic GP careers? A qualitative framework analysis of factors affecting the development of the academic GP workforce

BMJ Open
Objectives General practice continues to be an under-represented career choice among medical school graduates, and the retention of the general practitioner (GP) workforce remains challenging.
Lisi Gordon, Anita Laidlaw, Catherine Kennedy, Zoë McElhinney, Robert Scully   +4 more
doaj   +1 more source