Results 51 to 60 of about 2,024,000 (335)

SEC24A deficiency lowers plasma cholesterol through reduced PCSK9 secretion. [PDF]

, 2013
The secretory pathway of eukaryotic cells packages cargo proteins into COPII-coated vesicles for transport from the endoplasmic reticulum (ER) to the Golgi.
Adams, Elizabeth, Bai, Yongsheng, Baines, Andrea, Bajaj, Kanika, Chen, Xiao-Wei, Ginsburg, David, Lin, Jiandie, Liu, Hui-Hui, Ma, Danjun, Meng, Zhuo-Xian, Sartor, Maureen A, Schekman, Randy, Wang, He, Yi, Zhengping, Young, Stephen G, Yu, Genggeng, Zhang, Bin, Zhang, Pengcheng   +17 more
core   +1 more source

Transfer of Functional Cargo in Exomeres

Cell Reports, 2019
SUMMARY Exomeres are a recently discovered type of extracellular nanoparticle with no known biological function. Herein, we describe a simple ultracentrifugation-based method for separation of exomeres from exosomes.
Qin Zhang, J. Higginbotham, D. K. Jeppesen, Yu-Ping Yang, Wei Li, Eliot T. McKinley, Ramona Graves‐Deal, J. Ping, Colleen M. Britain, Kaitlyn A. Dorsett, Celine L. Hartman, D. Ford, Ryan M. Allen, K. Vickers, Qi Liu, J. Franklin, S. Bellis, R. Coffey   +17 more
semanticscholar   +1 more source

World tendences of civil aviation development and the enlargement of the Lithuanian civil aviation [PDF]

Transport, 2006
The article deals with global trends in civil aviation, such as: liberalisation of aviation market, globalisation of airlines, privatisation of airlines and invasion of low cost airlines into the market.
J. Butkevičius, A. Jarašūnienė
doaj  

Justification of the acceptability of a hybrid approach to passenger and freight flows' predictive modelling in the context of sustainable development [PDF]

E3S Web of Conferences
The relevance of the study is determined by the need for more accurate long-term forecasting in modeling passenger and freight flows. The methodological basis of the study consists of methods of analysis and forecasting of time series, methods of ...
Shapoval Ganna, Vasylenko Igor, Lytvynenko Sergiy, Kostiennikov Oleksii, Valko Alla, Viniukov-Proshchenko Artur   +5 more
doaj   +1 more source

Hoea a mai tōu waka – Claiming spaces for Māori tamariki and rangatahi in cognitive behaviour therapy [PDF]

, 2008
Cognitive Behaviour Therapy (CBT) has been shown to be an effective therapeutic intervention for a variety of psychological difficulties for children and youth (Barrett, Healey-Farrell, March, 2004; Stulemeijer, de Jong, Fiselier, Hoogveld, Bleijenberg ...
Cargo, Tania
core   +1 more source

The Cargo Receptor NDP52 Initiates Selective Autophagy by Recruiting the ULK Complex to Cytosol-Invading Bacteria

Molecules and Cells, 2019
Summary Xenophagy, a selective autophagy pathway that protects the cytosol against bacterial invasion, relies on cargo receptors that juxtapose bacteria and phagophore membranes. Whether phagophores are recruited from a constitutive pool or are generated
Benjamin J. Ravenhill, Keith B Boyle, Natalia von Muhlinen, Cara J. Ellison, G. Masson, Elsje G. Otten, Ágnes Foeglein, Roger L. Williams, F. Randow   +8 more
semanticscholar   +1 more source

Reconstitution of cargo-induced LC3 lipidation in mammalian selective autophagy

Science Advances, 2021
Reconstitution experiments show how different cargo receptors engage the autophagy machinery in unique ways to lipidate LC3. Selective autophagy of damaged mitochondria, protein aggregates, and other cargoes is essential for health.
Chunmei Chang, Xiaoshan Shi, Liv E. Jensen, A. Yokom, Dorotea Fracchiolla, S. Martens, J. Hurley   +6 more
semanticscholar   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Mathematical modeling of fastening conditions in piggyback transport: ensuring safety and stability across different transport modes

Discover Applied Sciences
Ensuring cargo stability during piggyback transportation is crucial for maintaining safety and efficiency, especially in intermodal transport systems. This study focuses on developing a mathematical model to optimise the fastening methods for vehicles ...
Ziyoda Mukhamedova, Diyor Boboyev, Shukhrat Saidivaliev, Rustam Abdullaev, Jamshid Kobulov, Sardorbek Akhmedov, Sherzod Fayzibayev   +6 more
doaj   +1 more source