Results 61 to 70 of about 2,024,000 (335)
Stall force of a cargo driven by N interacting motor proteins
, 2017 We study a generic one-dimensional model for an intracellular cargo driven by N motor proteins against an external applied force. The model includes motor-cargo and motor-motor interactions.
Bhat, Deepak, Gopalakrishnan, Manoj
core +1 more source
The newfound relationship between extrachromosomal DNAs and excised signal circles
FEBS Letters, EarlyView.Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley +1 more source
Ddigital logistics - efficient mechanism of development of transport systems
Ученые записки Российской академии предпринимательства, 2021 Modern digital technologies have turned the transportation system over and have opened new horizons in development. The formation of «digital transport and logistics» should be based on the existing frame of the transport system, but at the same time ...
E. V. Komarova, A. V. Vlasov
doaj
Zernovì Produkti ì Kombìkorma, 2021 The results of studies of the quality of food and non-food grain of wheat from the southern regions of Ukraine in 2016 harvest are presented. The indicators of the quality of wheat grain were determined, the uniformity of their distribution in different ...
A. Penaki, A. Borta
doaj +1 more source
Environmental control of microtubule-based bidirectional cargo-transport
, 2014 Inside cells, various cargos are transported by teams of molecular motors. Intriguingly, the motors involved generally have opposite pulling directions, and the resulting cargo dynamics is a biased stochastic motion.
Appert-Rolland, Cécile +2 more
core +3 more sources
PICALM::MLLT10 translocated leukemia
FEBS Letters, EarlyView.This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen +7 more
wiley +1 more source
Polyubiquitin chain-induced p62 phase separation drives autophagic cargo segregation
Cell Research, 2018 Misfolded proteins can be degraded by selective autophagy. The prevailing view is that ubiquitin-tagged misfolded proteins are assembled into aggregates by the scaffold protein p62, and the aggregates are then engulfed and degraded by autophagosomes ...
Daxiao Sun +4 more
semanticscholar +1 more source
Extracellular Vesicles as Delivery Vehicles of Specific Cellular Cargo
Cells, 2020 Extracellular vesicles (EVs) mediate cell-to-cell communication via the transfer of biomolecules locally and systemically between organs. It has been elucidated that the specific EV cargo load is fundamental for cellular response upon EV delivery ...
B. Mir, C. Goettsch
semanticscholar +1 more source
Structural biology of ferritin nanocages
FEBS Letters, EarlyView.Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley +1 more source
Integration of Synaptic Vesicle Cargo Retrieval with Endocytosis at Central Nerve Terminals
Frontiers in Cellular Neuroscience, 2017 Central nerve terminals contain a limited number of synaptic vesicles (SVs) which mediate the essential process of neurotransmitter release during their activity-dependent fusion.
Michael A. Cousin
doaj +1 more source