Results 21 to 30 of about 107,260 (262)

La caída de una camarera mayor

open access: yesLos Libros de la Corte.es, 2023
Cada vez son más los estudios que centran su atención en el poder informal que se daba en espacios cortesanos aparentemente no ligados a los principales núcleos de poder político, como eran los consejos de la monarquía.
Francisco José García Pérez
doaj   +1 more source

Proteasomal degradation of intracellularly expressed Amblyomin‐X limits suicide gene therapy potential in melanoma cells

open access: yesFEBS Open Bio, EarlyView.
This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel   +4 more
wiley   +1 more source

El buen pastor en Carlos II: equidad y crítica política

open access: yesHispania, 2013
Una de las metáforas más relevantes en el pensamiento político del barroco español se relaciona con la imagen bíblica del buen pastor. Ésta ayudó a desarrollar en la segunda mitad del siglo XVII imágenes de homogeneidad política a partir del rey.
Iván Sánchez Llanes
doaj   +1 more source

Acute caffeine treatment protects the developing retina from ischemia‐induced cell death

open access: yesFEBS Open Bio, EarlyView.
Caffeine reduces cell death in the developing retina under ischemia (OGD). This effect does not involve BDNF upregulation or antioxidant pathways (NRF2/VEGF). Neuroprotection occurs mainly through adenosine A2A receptor antagonism, decreasing glutamate release and excitotoxicity, highlighting caffeine's potential as an acute neuroprotective agent in ...
Amanda Alves Nascimento   +6 more
wiley   +1 more source

La reforma de predicadores en la Real Capilla de Carlos II

open access: yesHispania Sacra, 2019
El siguiente artículo persigue el estudio de la reforma de predicadores reales como parte de un programa reformista que afectó a todos los ámbitos de la Real Capilla.
Francisco José García Pérez
doaj   +1 more source

Transcripts enriched in codons that trigger P‐site tRNA‐mediated mRNA decay possess stable mRNA

open access: yesFEBS Open Bio, EarlyView.
PTMD codons were first described by Mendel et al. as mediators of an mRNA decay pathway dependent on the human protein CNOT3, homologous to yeast Not5. Our findings confirm that PTMD codons destabilize transcripts; however, unlike in yeast, the human pathway specifically targets and slightly destabilizes primarily stable mRNAs.
Rodolfo Lopes Carneiro   +1 more
wiley   +1 more source

MagmaFlow: A desktop platform for artificial intelligence‐driven expression analysis

open access: yesFEBS Open Bio, EarlyView.
MagmaFlow is a free, no‐code platform for gene expression analysis. It generates interactive volcano plots, links genes to literature, pathways, and diseases, prioritizes candidates using millions of publications, identifies affected biological processes, builds network diagrams, and exports publication‐ready figures and reports for macOS and Windows ...
Carlos E. Buss   +7 more
wiley   +1 more source

Developmental and Epileptic Encephalopathy due to Biallelic Pathogenic Variants in PIGM

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective PIGM encodes a critical enzyme in the glycosylphosphatidylinositol (GPI)‐anchor biosynthesis pathway. While promoter‐region mutations in PIGM have been associated with a relatively mild phenotype characterized by portal vein thrombosis and absence seizures, recent evidence suggests that coding‐region mutations result in a more severe
Júlia Sala‐Coromina   +11 more
wiley   +1 more source

La polarización dinástica en los Países Bajos: la nobleza flamenca borbonista entre España y Francia (hacia 1670-1706)

open access: yesCuadernos Dieciochistas
Este artículo arroja luz sobre el modo en que se construyó la adhesión a la sucesión borbónica en los Países Bajos. El estudio se centra en lo que puede describirse como la base social del borbonismo, a saber, un número relativamente reducido de familias
Thomas Glesener
doaj   +1 more source

El nuncio Federico Borromeo y la caída del padre Nithard (1668–69)

open access: yesInvestigaciones Históricas, 2021
El artículo estudia la intervención del nuncio de Clemente IX, Federico Borromeo, como mediador en la crisis política que supuso la salida de la corte y de España del jesuita Everardo Nithard, confesor y favorito de la reina Mariana de Austria, al final
Luis Ribot García
doaj   +1 more source

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