Results 31 to 40 of about 1,622,147 (309)
Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma
Molecular Oncology, EarlyView.Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra +6 more
wiley +1 more source
Revista de Historia ModernaReseña del libro de SANZ CAMAÑES, Porfirio, En la periferia del Imperio español. Fidelidad, guerra y supervivencia en el Aragón de Carlos II, Madrid, Sílex ediciones, 2024, 256 pp. ISBN: 978-84-10267-06-0.
Enrique Solano Camón
doaj +1 more source
El buen pastor en Carlos II: equidad y crítica política
Hispania, 2013 Una de las metáforas más relevantes en el pensamiento político del barroco español se relaciona con la imagen bíblica del buen pastor. Ésta ayudó a desarrollar en la segunda mitad del siglo XVII imágenes de homogeneidad política a partir del rey.
Iván Sánchez Llanes
doaj +1 more source
Molecular Oncology, EarlyView.In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera +11 more
wiley +1 more source
Carlos II de España, «El hechizado» [PDF]
Revista médica de Chile, 2008 The death of King Charles II, «the Bewitched», ended two centuries of sovereignity of the Habsburg dynasty in Spain. Since his birth in 1661, he presented a peculiar set of physical, psychiatric and behavioral signs, such as respiratory and diarrheal diseases, recurrent seizures and deep developmental delay.
openaire +2 more sources
La reforma de predicadores en la Real Capilla de Carlos II
Hispania Sacra, 2019 El siguiente artículo persigue el estudio de la reforma de predicadores reales como parte de un programa reformista que afectó a todos los ámbitos de la Real Capilla.
Francisco José García Pérez
doaj +1 more source
Angiotensin II, via angiotensin receptor type 1/nuclear factor-κB activation, causes a synergistic effect on interleukin-1-β-induced inflammatory responses in cultured mesangial cells [PDF]
, 2015 Introduction: The nuclear factor-κB (NF-κB) is an important regulator of the inflammatory response. Angiotensin II (Ang II) activates the NF-κB pathway linked to renal inflammation. Although both AT1 and AT2 receptors are involved in Ang II-mediated NF-
Alberto Ortiz +12 more
core +2 more sources
Molecular Oncology, EarlyView.Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena +15 more
wiley +1 more source
El nuncio Federico Borromeo y la caída del padre Nithard (1668–69)
Investigaciones Históricas, 2021 El artículo estudia la intervención del nuncio de Clemente IX, Federico Borromeo, como mediador en la crisis política que supuso la salida de la corte y de España del jesuita Everardo Nithard, confesor y favorito de la reina Mariana de Austria, al final
Luis Ribot García
doaj +1 more source
FEBS Open Bio, EarlyView.This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel +4 more
wiley +1 more source