Results 41 to 50 of about 8,106,136 (327)
β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1
Molecular Oncology, EarlyView.Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero +8 more
wiley +1 more source
Synthesis, Characterization, and Photochemical Properties of a New Square Mn(I)-Ru(II) Complex Using Pyrazine as Bridge Ligand [PDF]
, 2013 The photochemical properties of the complexes cis,fac-[Ru(phen)(2)(pz)(2)-Mn(CO)(3)Br](2)(4+) (I), cis-[Ru(phen)(2)(pz)(2)](2+) (II), and fac-Mn(CO)(3)(pz)(2)Br (III) where phen is phenanthroline and pz is pyrazine in acetonitrile solution are reported ...
Aguiar, Inara de +3 more
core +3 more sources
Aggressive prostate cancer is associated with pericyte dysfunction
Molecular Oncology, EarlyView.Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero +11 more
wiley +1 more source
La caída de una camarera mayor
Los Libros de la Corte.es, 2023 Cada vez son más los estudios que centran su atención en el poder informal que se daba en espacios cortesanos aparentemente no ligados a los principales núcleos de poder político, como eran los consejos de la monarquía.
Francisco José García Pérez
doaj +1 more source
Screening for lung cancer: A systematic review of overdiagnosis and its implications
Molecular Oncology, EarlyView.Low‐dose computed tomography (CT) screening for lung cancer may increase overdiagnosis compared to no screening, though the risk is likely low versus chest X‐ray. Our review of 8 trials (84 660 participants) shows added costs. Further research with strict adherence to modern nodule management strategies may help determine the extent to which ...
Fiorella Karina Fernández‐Sáenz +12 more
wiley +1 more source
La leyenda negra contra España durante el Romanticismo inglés: las colecciones biográficas de Mary Hays [PDF]
, 2016 En este trabajo se analizan las referencias a España en dos colecciones biográficas de la escritora inglesa Mary Hays: Female Biography (1803) y Memoirs of Queens (1821), pues en ellas aparecen varios hechos históricos en los que se ha fundamentado
Lasa Álvarez, Begoña
core +2 more sources
Molecular Oncology, EarlyView.The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg +43 more
wiley +1 more source
El buen pastor en Carlos II: equidad y crítica política
Hispania, 2013 Una de las metáforas más relevantes en el pensamiento político del barroco español se relaciona con la imagen bíblica del buen pastor. Ésta ayudó a desarrollar en la segunda mitad del siglo XVII imágenes de homogeneidad política a partir del rey.
Iván Sánchez Llanes
doaj +1 more source
La justicia en venta. El beneficio de cargos americanos de audiencia bajo Carlos II (1683-1700)
, 2012 The article deals with the provision and «beneficio» (sale) of Justice appointments to Spanish American Audiencias (Higher Courts) in the 17th century, that modifies and completes previous research. The sale process of posts in American Audiencias (Crown
Á. Tapia
semanticscholar +1 more source
El Real Laboratorio Químico (1694-1700) [PDF]
, 1996 La renovación de la ciencia en la España de finales del siglo XVII tiene, en la creación del Real Laboratorio Químico, uno de sus acontecimientos interesantes.
María Esther Alegre Pérez +1 more
core +1 more source