Results 11 to 20 of about 162,227 (374)
Biomolecules, 2021 The SLC25A20 transporter, also known as carnitine acyl-carnitine carrier (CAC), catalyzes the transport of short, medium and long carbon chain acyl-carnitines across the mitochondrial inner membrane in exchange for carnitine.
Annamaria Tonazzi +4 more
doaj +2 more sources
International Journal of Molecular Sciences, 2022 Mitochondria control cellular fate by various mechanisms and are key drivers of cellular metabolism. Although the main function of mitochondria is energy production, they are also involved in cellular detoxification, cellular stabilization, as well as ...
M. Virmani, Maria Cirulli
semanticscholar +1 more source
L-Carnitine and Acylcarnitines: Mitochondrial Biomarkers for Precision Medicine
Metabolites, 2021 Biomarker discovery and implementation are at the forefront of the precision medicine movement. Modern advances in the field of metabolomics afford the opportunity to readily identify new metabolite biomarkers across a wide array of disciplines.
M. R. McCann +3 more
semanticscholar +1 more source
CRIP1 suppresses BBOX1‐mediated carnitine metabolism to promote stemness in hepatocellular carcinoma
EMBO Journal, 2022 Carnitine metabolism is thought to be negatively correlated with the progression of hepatocellular carcinoma (HCC) and the specific molecular mechanism is yet to be fully elucidated.
Jing Wang +10 more
semanticscholar +1 more source
Nature Microbiology, 2021 The heightened cardiovascular disease (CVD) risk observed among omnivores is thought to be linked, in part, to gut microbiota-dependent generation of trimethylamine- N -oxide (TMAO) from l -carnitine, a nutrient abundant in red meat.
J. Buffa +32 more
semanticscholar +1 more source
Theranostics, 2021 High-throughput metabolite profiling provides the opportunity to reveal metabolic mechanisms and identify biomarkers. Psoriasis is an immune-mediated chronic inflammatory disease. However, the role of metabolism in psoriasis pathogenesis remains unclear.
Chao Chen +5 more
semanticscholar +1 more source
Role of Carnitine in Non-alcoholic Fatty Liver Disease and Other Related Diseases: An Update
Frontiers in Medicine, 2021 Carnitine is an amino acid-derived substance that coordinates a wide range of biological processes. Such functions include transport of long-chain fatty acids from the cytoplasm to the mitochondrial matrix, regulation of acetyl-CoA/CoA, control of inter ...
Na Li, Hui Zhao
semanticscholar +1 more source
Proceedings of the National Academy of Sciences of the United States of America, 2021 Significance Trimethylamine (TMA) is a disease-associated metabolite produced in the human body exclusively by microbes. Gut microbes generate TMA from essential nutrients consumed in the human diet, including l-carnitine.
L. Rajakovich +3 more
semanticscholar +1 more source
Potential Role of L-Carnitine in Autism Spectrum Disorder
Journal of Clinical Medicine, 2021 L-carnitine plays an important role in the functioning of the central nervous system, and especially in the mitochondrial metabolism of fatty acids. Altered carnitine metabolism, abnormal fatty acid metabolism in patients with autism spectrum disorder ...
Alina Kępka +6 more
semanticscholar +1 more source
Biological roles of l‐carnitine in oocyte and early embryo development
Molecular Reproduction and Development, 2021 Poor oocyte quality is responsible for female infertility. Multiple studies have been carried out to find supplements to enhance oocyte quality and mitigate infertility problems.
Jiajian Li +5 more
semanticscholar +1 more source