Results 181 to 190 of about 15,119 (225)
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Carnosine and Carnosinase in Rat Tissue
Nature, 1957PAPER chromatography has been used for obtaining a qualitative picture of the distribution of carnosine and ‘carnosinase’ in the albino rat.
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Carnosine and Carnosine-Related Antioxidants: A Review
Current Medicinal Chemistry, 2005First isolated and characterized in 1900 by Gulewitsch, carnosine ( β-alanyl-L-hystidine) is a dipeptide commonly present in mammalian tissue, and in particular in skeletal muscle cells; it is responsible for a variety of activities related to the detoxification of the body from free radical species and the by-products of membrane lipids ...
Andrea Guiotto +3 more
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Carnosine and Diabetic Nephropathy
Current Medicinal Chemistry, 2020Diabetic Nephropathy (DN) is a major complication in patients with type 1 or type 2 diabetes and represents the leading cause of end-stage renal disease. Novel therapeutic approaches are warranted. In view of a polymorphism in the carnosinase 1 gene CNDP1, resulting in reduced carnosine degradation activity and a significant DN risk reduction ...
Verena, Peters +2 more
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Current Medicinal Chemistry, 2020
Carnosine (β-alanyl-L-histidine) is a small dipeptide with numerous activities, including antioxidant effects, metal ion chelation, proton buffering capacity, and inhibitory effects on protein carbonylation and glycation. Carnosine has been mostly studied in organs where it is abundant, including skeletal muscle, cerebral cortex, kidney, spleen, and ...
Ken-Ichiro, Tanaka, Masahiro, Kawahara
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Carnosine (β-alanyl-L-histidine) is a small dipeptide with numerous activities, including antioxidant effects, metal ion chelation, proton buffering capacity, and inhibitory effects on protein carbonylation and glycation. Carnosine has been mostly studied in organs where it is abundant, including skeletal muscle, cerebral cortex, kidney, spleen, and ...
Ken-Ichiro, Tanaka, Masahiro, Kawahara
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Carnosine in Nucleated Erythrocytes
Nature, 1974IN the course of studies of the metabolism of intracerebrally administered L-U-14C-histidine in brains of mice and frogs (Rana pipiens), analyses were also performed on blood samples from the injected animals. The mice received 1.5×106 c.p.m. of the labelled histidine, and 1 h later samples of blood were taken by means of orbital puncture.
J N, Van Balgooy +2 more
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Experientia, 1981
Carnosine levels were determined in chick erythrocytes (2510 nmoles/g cells) and plasma from chick (27 nmoles/ml),rat and rabbit. Carnosine was also measured in rabbit reticulocyte-rich blood (105 nmoles/g cells), normal blood (18 nmoles/g cells) and in bone marrow.
J E, Seely, F D, Marshall
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Carnosine levels were determined in chick erythrocytes (2510 nmoles/g cells) and plasma from chick (27 nmoles/ml),rat and rabbit. Carnosine was also measured in rabbit reticulocyte-rich blood (105 nmoles/g cells), normal blood (18 nmoles/g cells) and in bone marrow.
J E, Seely, F D, Marshall
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Neurochemical Research, 1977
The amount and specificity of binding ofL-carnosine (β-alanyl-L-histidine) by crude soluble and particulate fractions of several tissues were investigated with proton magnetic resonance ((1)HMR) spectrometry. It was found that the particulate fraction of only nasal olfactory mucosa exhibited a specific binding requiring a particular orientation of the ...
C E, Brown +4 more
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The amount and specificity of binding ofL-carnosine (β-alanyl-L-histidine) by crude soluble and particulate fractions of several tissues were investigated with proton magnetic resonance ((1)HMR) spectrometry. It was found that the particulate fraction of only nasal olfactory mucosa exhibited a specific binding requiring a particular orientation of the ...
C E, Brown +4 more
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Carnosine treatment largely prevents alterations of renal carnosine metabolism in diabetic mice
Amino Acids, 2011Recently, we identified an allelic variant of human carnosinase 1 (CN1) that results in increased enzyme activity and is associated with susceptibility for diabetic nephropathy in humans. Investigations in diabetic (db/db) mice showed that carnosine ameliorates glucose metabolism effectively.
Verena Peters +5 more
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Plasma carnosine, but not muscle carnosine, attenuates high-fat diet-induced metabolic stress
Applied Physiology, Nutrition, and Metabolism, 2015There is growing in vivo evidence that the dipeptide carnosine has protective effects in metabolic diseases. A critical unanswered question is whether its site of action is tissues or plasma. This was investigated using oral carnosine versus β-alanine supplementation in a high-fat diet rat model.
S. Stegen +10 more
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Brain Research, 1979
The dipeptide, carnosine, its synthetic enzyme, carnosine synthetase, and its degradative enzyme, carnosinase, appear to be localized in the cytosol of mouse olfactory bulb and epithelium. Mouse olfactory bulbs and epithelium were prelabeled in vivo with [3H]carnosine following intranasal irrigation with [3H]beta-alanine.
J W, Harding, J V, O'Fallon
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The dipeptide, carnosine, its synthetic enzyme, carnosine synthetase, and its degradative enzyme, carnosinase, appear to be localized in the cytosol of mouse olfactory bulb and epithelium. Mouse olfactory bulbs and epithelium were prelabeled in vivo with [3H]carnosine following intranasal irrigation with [3H]beta-alanine.
J W, Harding, J V, O'Fallon
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