Results 91 to 100 of about 179,773 (311)

Carbon Monoxide Nanomodulator Reverses Ischemia‐Reperfusion Injury in Stroke: A Novel Dual‐Channel Therapy Mode of Co‐driving Neuroprotection and Neurogenesis

Advanced Science, EarlyView.
This work develops a biomimetic and reactive oxygen species‐activated carbon monoxide (CO) nanogenerator to penetrate blood‐brain barrier, arrive in stroke‐affected regions, and release CO in a controlled manner for an innovative dual‐channel therapy strategy via co‐driving neuroprotection and neurogenesis.
Xuegang Niu, Bin Gao, Hongyi Huang, Zesheng Li, Yibin Zhang, Quanlei Liu, Chao Zhang, Yang Dai, Jinkun Xu, Mingshan Liu, Yuanyuan Zhang, Yihe Wang, Penghu Wei, Yuanxiang Lin, Yongzhi Shan, Yumin Luo, Dezhi Kang, Guoguang Zhao   +17 more
wiley   +1 more source

Multiscale optoacoustic assessment of skin microvascular reactivity in carotid artery disease

Photoacoustics
Microvascular endothelial dysfunction may provide insights into systemic diseases, such as carotid artery disease. Raster-scan optoacoustic mesoscopy (RSOM) can produce images of skin microvasculature during endothelial dysfunction challenges via ...
Angelos Karlas, Nikoletta Katsouli, Nikolina-Alexia Fasoula, Mario Reidl, Rhiannon Lees, Lan Zang, Maria del Pilar Ortega Carrillo, Stefan Saicic, Christoph Schäffer, Leontios Hadjileontiadis, Daniela Branzan, Vasilis Ntziachristos, Hans-Henning Eckstein, Michael Kallmayer   +13 more
doaj   +1 more source

Serum Resistin Level and Progression of Atherosclerosis during Glucocorticoid Therapy for Systemic Autoimmune Diseases

Metabolites, 2016
Adipokines are important regulators of several processes, including inflammation and atherosclerosis. In patients with systemic autoimmune diseases, atherosclerosis is accelerated with higher cardiovascular morbidity and mortality.
Nahoko Tanaka, Shotaro Masuoka, Natsuko Kusunoki, Toshihiro Nanki, Shinichi Kawai   +4 more
doaj   +1 more source

High fat diet attenuates the anticontractile activity of aortic PVAT via a mechanism involving AMPK and reduced adiponectin secretion [PDF]

, 2018
Background and aim: Perivascular adipose tissue (PVAT) positively regulates vascular function through production of factors such as adiponectin but this effect is attenuated in obesity.
Alganga, Husam, Almabrouk, Tarek A.M., Guzik, Tomasz J., Katwan, Omar J., Kennedy, Simon, Salt, Ian P., Skiba, Dominik S., Touyz, Rhian M., Ugusman, Azizah B., White, Anna D.   +9 more
core   +2 more sources

Microglial Fkbp5 Impairs Post‐Stroke Vascular Integrity and Regeneration by Promoting Yap1‐Mediated Glycolysis and Oxidative Phosphorylation

Advanced Science, EarlyView.
A post‐stroke perivascular niche of microglia characterized by low expression of M2 markers and elevated glycolysis, oxidative phosphorylation (OXPHOS), and phagocytic activity is identified, which is termed stroke‐activated vascular‐associated microglia (stroke‐VAM).
Yanan Li, Yanmei Qiu, Yunlei Yang, Yanhao Wei, Haokun Peng, Longhai Zeng, Pengcheng Li, Rentang Bi, Bo Hu   +8 more
wiley   +1 more source

Advances in endovascular therapy for ischemic cerebrovascular diseases

Chronic Diseases and Translational Medicine, 2016
Endovascular therapy for ischemic cerebrovascular diseases has developed rapidly in recent years. The latest clinical trials of acute ischemic stroke have shown promising results with the continued advancement of concepts, techniques, and materials ...
Jun Lu, Daming Wang
doaj   +1 more source

The acute effect of maximal exercise on central and peripheral arterial stiffness indices and hemodynamics in children and adults [PDF]

, 2016
Xavier Melo is supported by a research grant from the Foundation for Science and Technology (FCT), Ministry of Education and Science of Portugal (grant: SFRH/ BD/ 70515/ 2010). Nuno M.
Fernhall, Bo, Melo, Xavier, Pimenta, Nuno, Pinto, Rita, Santa-Clara, Helena, Santos, Diana, Sardinha, Luis   +6 more
core   +1 more source

Contribution of Gli1+ Adventitial Stem Cells to Smooth Muscle Cells in Atherosclerosis and Vascular Injury

Advanced Science, EarlyView.
Gli1+ adventitial stem cells (ASCs) have been thought to generate smooth muscle cells (SMCs) in atherosclerosis. Using a dual‐recombinase lineage tracing to exclude ectopic labeling, Wang et al. found that Gli1+ ASCs do not contribute to SMCs in atherosclerotic plaques.
Haixiao Wang, Xiuzhen Huang, Jialing Mou, Enci Wang, Yan Li, Wenjuan Pu, Yao Xie, Xiaoling Guo, Lixing Wang, Maoping Chu, Bin Zhou, Chao Niu   +11 more
wiley   +1 more source

Echolucency of carotid plaque is useful for selecting high-risk patients with chronic coronary artery disease who benefit from intensive lipid-lowering therapy [PDF]

, 2021
Manabu Uematsu, Takamitsu Nakamura, Takeo Horikoshi, Toru Yoshizaki, Yosuke Watanabe, Tsuyoshi Kobayashi, Yukio Saitō, Kazuto Nakamura, Jun–ei Obata, Kiyotaka Kugiyama   +9 more
openalex   +1 more source

Computational fluid dynamicaccuracy in mimicking changes in blood hemodynamics in patients with acute type IIIb aortic dissection treated with TEVAR [PDF]

, 2018
Background: We aimed to verify the accuracy of the Computational Fluid Dynamics (CFD) algorithm for blood flow reconstruction for type IIIb aortic dissection (TBAD) before and after thoracic endovascular aortic repair (TEVAR).
Domenig, Christoph, Huk, Ihor, Nanobachvili, Josif, Neumayer, Christoph, Piechota-Polańczyk, Aleksandra, Polanczyk, Andrzej   +5 more
core   +1 more source