Results 81 to 90 of about 2,681,423 (292)

Similarity between carotid and coronary artery responses to sympathetic stimulation and the role of alpha-1 receptors in humans [PDF]

, 2018
Background. Carotid artery (CCA) dilation occurs in healthy subjects during cold pressor test (CPT), whilst the magnitude of dilation relates to cardiovascular risk. To further explore this phenomena and mechanism, we examined carotid artery responses to
Daniel J. Green, Ainslie, Philip N., Green, Daniel, Thijs P. Kerstens, Kerstens, Thijs, Green, DJ, Tymko, MM, Thijsen, Dick, Tymko, M.M., Kerstens, TP, Michael M. Tymko, Stembridge, Mike, Thijssen, DHJ, Stembridge, M., Anke C.C.M. van Mil, Kerstens, T.P., Philip N. Ainslie, Mil, A.C.C.M. van, Mike Stembridge, van Mil, AC, Thijssen, D.H.J., Tymko, Michael, Stembridge, M, Green, D.J., Ainslie, PN, Ainslie, P.N., van Mil, Anke, Dick H. J. Thijssen   +27 more
core   +1 more source

Modulation of miR‐23b Wnt/β‐catenin Axis Strengthens Endothelial Barrier Properties

Advanced Science, EarlyView.
Early blood‐brain barrier (BBB) disruption contributes to stroke and CNS disease pathology. miR‐23b was identified as a regulator of BBB integrity in brain endothelial cells. Inhibition of miR‐23b enhanced barrier‐associated properties, promoted repair‐related signaling, and reduced BBB leakage in experimental stroke models, supporting further ...
Victor Anthony Martinez, Rose E. Presby, Sara Nakanishi, Pallavi Gaur, Ugur Akcan, Johannes Daugaard Krog, Iben Daugaard Krog, Lipi Das, David S. Johnson, Danny Jamoul, Douglas Jury, Brian Lawson, Jacob Körbelin, Lewis M. Brown, Vilas Menon, Dritan Agalliu, Irene Munk Pedersen   +16 more
wiley   +1 more source

Astrocytic LMP2 Coordinates NF‐κB and TGF‐β1/Smad3 Signaling to Drive Neuroinflammation after Cerebral Ischemia/Reperfusion

Advanced Science, EarlyView.
ABSTRACT Astrocyte reactivity critically shapes neuroinflammatory outcomes after ischemic stroke, yet the upstream regulators governing astrocyte state transitions remain incompletely defined. Here, we identify the immunoproteasome subunit low molecular weight protein 2 (LMP2) as an important modulator of astrocyte functional remodeling following ...
Yanguang Mao, Rulan Ma, Zejing Lin, Huiying Zhao, Yuexian Liu, Yonghe Su, Xu Zhang, Xingyong Chen   +7 more
wiley   +1 more source

The relationship between Intima-Media Thickness and Carotid Plaque Characteristics with Incidence and Severity of Premature Coronary Artery Disease

Novelty in Biomedicine, 2023
Background: Carotid intima media thickness (CIMT) and carotid plaque can predict premature coronary heart disease (PCAD) in patients hospitalized due to coronary artery disease or undergoing therapeutic interventions.
Mohammad Haji Aghajani, Masoomeh Raoufi, Roxana Sadeghi, Faezeh Arefinia, Mohammad Parsa Mahjoob   +4 more
doaj  

Symptomatic Bilateral Carotid Artery Occlusion: An Uncommon Pattern of Carotid Pathology

Vascular Specialist International, 2018
We report an unusual case of an 83-year-old man who was admitted with dizziness and repeated drop attacks. He was diagnosed with bilateral carotid artery occlusion and he underwent a left subclavian to left carotid bypass with ringed ...
Chrisostomos Maltezos, Christiana Anastasiadou, Anastasios Papapetrou, George Galyfos, Ioannis Sachmpazidis, Gerasimos Papacharalampous   +5 more
doaj   +1 more source

Targeted Degradation of STING by a Neutrophil Membrane‐Coated Nanoplatform Suppresses Microglial Pyroptosis After Subarachnoid Hemorrhage

Advanced Science, EarlyView.
MG1@NM‐Px serves as a microglia‐targeted STING‐degrading nanoplatform for subarachnoid hemorrhage. Following systemic administration, it crosses the blood–brain barrier and accumulates in activated microglia. STP1‐mediated STING ubiquitination and degradation suppress MAPK/inflammasome signaling, GSDME‐mediated pyroptosis, and IL‐1β release, revealing ...
Ruotian Zhang, Kaikun Yuan, Haoyu Zou, Hanfeng Qin, Jiale Liu, Jianda Sun, Feifan Zhang, Yuankui Wang, Tong Wang, Jiaxing Dai, Chunxu Li, Yichi Chen, Yingfeng Tu, Huaizhang Shi   +13 more
wiley   +1 more source

The safety and performance of the new Nitinol stent in the treatment of carotid artery stenosis : one and six month follow-up [PDF]

, 2009
Background The purpose of the trial was to evaluate the safety and performance of the new Protégé stent in the treatment of common and/or internal carotid artery stenoses. Methods The Protégé® GPS stent is a self-expanding Nitinol stent system.
Franke, Jennifer
core  

Polydopamine Nanoparticle‐Mediated Precise Near‐Infrared Optical Stimulation for Cognitive Enhancement

Advanced Science, EarlyView.
Polydopamine nanoparticles enable a precise, non‐genetic, and transcranial neuromodulation strategy via near‐infrared photothermal stimulation. By activating TRPV1 channels, this approach specifically enhances hippocampal gamma oscillations, thereby rescuing spatial memory deficits in models of perioperative neurocognitive disorder.
Yan‐Bo Zhou, Qiong Xue, Su‐Xuan Hou, Ke‐Yao Zhang, Wei‐Tong Pan, Ting‐Ting Zeng, Yu‐Ge Wang, Daqing Ma, Chenguang Zhao, Pan‐Miao Liu, Jian‐Jun Yang   +10 more
wiley   +1 more source

光学相干断层成像在颈内动脉系统中的应用进展 Application Progress of Optical Coherence Tomography in Internal Carotid Artery System

Zhongguo cuzhong zazhi, 2018
颈内动脉系统供应脑的前循环。颈内动脉粥样硬化、颈动脉血管炎以及颈内动脉夹层等病 变均会导致血管腔狭窄、斑块破裂及继发血栓的形成，继而引起缺血性脑血管病。本文介绍颈动脉 系统光学相干断层成像（optical coherence tomography, OCT）成像方法、OCT对颈动脉病变的评价方法 以及在颈动脉支架置入过程中的应用，并对OCT技术在颈动脉系统中的应用优劣势和前景进行展望。 Abstract: Internal carotid artery system supplies the
刘锐，李敏，朱武生，殷勤，刘新峰
doaj   +1 more source

USP5 Stabilizes TGFBR1 to Drive Vascular Smooth Muscle Cell Senescence and Atherosclerosis

Advanced Science, EarlyView.
This study reveals that USP5 drives vascular smooth muscle cell senescence and atherosclerosis by stabilizing TGFBR1, suppressing IDH2, and promoting glycolytic reprogramming, identifying the USP5‐TGFBR1‐IDH2 axis as a potential therapeutic target. ABSTRACT Vascular smooth muscle cell (VSMC) senescence contributes importantly to atherosclerotic plaque ...
Xinhai Cui, Yuanlong Hu, Lin Lin, Lei Zhang, Chao Li, Yunlun Li   +5 more
wiley   +1 more source