Results 101 to 110 of about 164,521 (355)

Using pneumococcal carriage studies to monitor vaccine impact in low- and middle-income countries.

Vaccine, 2019
Pneumococcal disease is a leading cause of childhood mortality, globally. The pneumococcal conjugate vaccine (PCV) has been introduced to many countries worldwide.
J. Chan, C. Nguyen, E. Dunne, E. Kim Mulholland, Tuya Mungun, W. Pomat, E. Rafai, C. Satzke, D. Weinberger, F. Russell   +9 more
semanticscholar   +1 more source

Clonal expansion within pneumococcal serotype 6C after use of seven-valent vaccine [PDF]

, 2013
Streptococcus pneumoniae causes invasive infections, primarily at the extremes of life. A seven-valent conjugate vaccine (PCV7) is used to protect against invasive pneumococcal disease in children.
Nicholas J Loman, Jacqueline Chan, Tocheva Anna S., O’Connor Leigh, Pallen, Mark J., Constantinidou C., Loman, Nicholas J., Pallen M.J., Faust, Saul N, Faust, Saul N., Loman, Nicholas, Clarke S.C., Tocheva A.S., Constantinidou Chrystala, Mark J Pallen, Loman, Nicholas J, Chan, Jacqueline, Constantinidou, Chrystala, Stuart C Clarke, Pallen, Mark J, Gladstone R.A., O'Connor, Leigh, Chrystala Constantinidou, Clarke, Stuart C, Tocheva, Anna S., Faust, S.N., Clarke, S.C., Johanna M C Jefferies, Loman Nicholas J., Faust Saul N., Clarke Stuart C., Gladstone, Rebecca A., Chan J., O’Connor, Leigh, Leigh O'Connor, Anna S Tocheva, Clarke, Stuart C., Pallen, Mark, Tocheva, Anna S, Jefferies J.M.C., Jefferies, Johanna M C, Loman N.J., Chan Jacqueline, Jefferies, Johanna M.C., Gladstone, Rebecca, Saul N Faust, Jefferies Johanna M. C., Jefferies, Johanna M. C., Faust S.N., Pallen Mark J., Gladstone, Rebecca A, Rebecca A Gladstone, O'Connor L., Gladstone Rebecca A.   +53 more
core   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

Genomic, Transcriptomic, and Phenotypic Analyses of Neisseria meningitidis Isolates from Disease Patients and Their Household Contacts

mSystems, 2017
Neisseria meningitidis (meningococcus) can cause meningococcal disease, a rapidly progressing and often fatal disease that can occur in previously healthy children.
Xiaoyun Ren, David A. Eccles, Gabrielle A. Greig, Jane Clapham, Nicole E. Wheeler, Stinus Lindgreen, Paul P. Gardner, Joanna K. MacKichan   +7 more
doaj   +1 more source

Pneumococcal carriage, density, and co-colonization dynamics: a longitudinal study in Indonesian infants.

International Journal of Infectious Diseases, 2019
OBJECTIVES Nasopharyngeal carriage of Streptococcus pneumoniae underpins disease development and transmission. We examined pneumococcal carriage dynamics, including density and multiple serotype carriage, in Indonesian infants during the first year of ...
C. Murad, E. Dunne, S. Sudigdoadi, E. Fadlyana, Rodman Tarigan, Casey L. Pell, Emma Watts, C. Nguyen, C. Satzke, J. Hinds, Mia Milanti Dewi, Meita Dhamayanti, N. Sekarwana, Kusnandi Rusmil, E. Mulholland, C. Kartasasmita   +15 more
semanticscholar   +1 more source

Multiple Colonization with S. pneumoniae before and after Introduction of the Seven-Valent Conjugated Pneumococcal Polysaccharide Vaccine [PDF]

, 2010
Background: Simultaneous carriage of more than one strain of Streptococcus pneumoniae promotes horizontal gene transfer events and may lead to capsule switch and acquisition of antibiotic resistance. We studied the epidemiology of cocolonization with S.
Hinds Jason, Brugger, Silvio D., Frey, Pascal, Hinds, Jason, Brugger Silvio D., Frey Pascal, Silvio D Brugger, Silvio D. Brugger, Hinds, J, Brugger, SD, Aebi, S, Jason Hinds, Kathrin Mühlemann, Mühlemann, K, Suzanne Aebi, Mühlemann Kathrin, Aebi Suzanne, Aebi, Suzanne, Mühlemann, Kathrin, Pascal Frey, Frey, P   +20 more
core   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Persistence and Diffusion of mecC-Positive CC130 MRSA Isolates in Dairy Farms in Meurthe-et-Moselle County (France)

Frontiers in Microbiology, 2019
Background: Methicillin resistance in Staphylococcus aureus (MRSA) is classically conferred by the acquisition of the mecA gene encoding an additional penicillin binding protein with low affinity for beta-lactams.
Jacques Bietrix, Jacques Bietrix, Camille Kolenda, Camille Kolenda, Anaïs Sapin, Marisa Haenni, Jean-Yves Madec, Michèle Bes, Michèle Bes, Michèle Bes, Céline Dupieux, Céline Dupieux, Céline Dupieux, Jason Tasse, Fréderic Laurent, Fréderic Laurent, Fréderic Laurent, Fréderic Laurent   +17 more
doaj   +1 more source

Antimicrobial-Resistant Klebsiella pneumoniae Carriage and Infection in Specialized Geriatric Care Wards Linked to Acquisition in the Referring Hospital

bioRxiv, 2017
Background Klebsiella pneumoniae is a leading cause of extended-spectrum beta-lactamase (ESBL) producing hospital-associated infections, for which elderly patients are at increased risk.
C. Gorrie, M. Mirčeta, R. Wick, L. Judd, K. Wyres, N. Thomson, R. Strugnell, N. Pratt, J. Garlick, K. Watson, P. Hunter, S. Mcgloughlin, D. Spelman, A. Jenney, K. Holt   +14 more
semanticscholar   +1 more source

Serotype 19A and 6C account for one-third of pneumococcal carriage among Belgian day-care children four years after a shift to a lower-valent PCV

, 2023
: Background Pneumococcal conjugate vaccines (PCVs) effectively reduce infection and asymptomatic carriage of Streptococcus pneumoniae vaccine serotypes. In 2016, Belgium replaced its infant PCV13 program by a 4-year period of PCV10.
Willen, Laura, Vermeulen, Helene, van Heirstraeten, Liesbet, Wouters, Ine, Desmet, Stefanie, van Damme, Pierre, Goossens, Herman, Beutels, Philippe, Lammens, Christine, Verhaegen, Jan, Malhotra, Surbhi, Ekinci, Esra, Theeten, Heidi   +12 more
core