Results 121 to 130 of about 168,461,955 (277)

Identitet prijevoznika kod ugovora o time-charteru

open access: yesUporedno pomorsko pravo, 1996
Identitet prijevoznika kod brodarskog ugovora na vrijeme (time-charter-a) jedan je od najčešćih problema koji se javljaju kod prijevoza tereta morem. Vlasnici tereta ponekad nisu sigurni od koga trebaju tražiti naknadu štete - od vlasnika broda ili od ...
Časlav Pejović
doaj  

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

open access: yesMolecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder   +10 more
wiley   +1 more source

Paramount klauzula - Pretvaranje iznosa ograničenja brodarove odgovornosti u valutu plaćanja : [prikaz presude]

open access: yesUporedno pomorsko pravo, 1996
Kada su stranke ugovorile tzv. Paramount klauzulu, a potrebno je utvrditi granicu odgovornosti prijevoznika za gubitak tereta, vrijednost sto zlatnih funti sterlinga utvrđuje se prema engleskom Zakonu o kovanju novca iz 1870.
Viktorija Lovrić
doaj  

MITF maintains genome stability in nonmelanocyte lineages

open access: yesMolecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir   +13 more
wiley   +1 more source

Article 47(2) of the Rotterdam Rules: Solution of old problems or a new confusion?

open access: yesPoredbeno Pomorsko Pravo, 2013
The Rotterdam Rules, adopted by UNCITRAL in 2008, address a number of issues that have not been regulated by previous international conventions, such as the delivery of goods and the right of control.
Časlav Pejović
doaj  

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

open access: yesMolecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka   +9 more
wiley   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

open access: yesMolecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu   +13 more
wiley   +1 more source

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