Results 261 to 270 of about 2,646,292 (297)

Enhancing solid tumor therapy with sequential delivery of dexamethasone and docetaxel engineered in a single carrier to overcome stromal resistance to drug delivery.

Journal of Controlled Release, 2019
Nanomedicines are often designed to target and treat solid tumors. Unfortunately, tumor and stroma composed of dense extracellular matrix, abnormal vascular barriers, elevated interstitial fluid pressure, et al., which impede the access and accumulation ...
Lu Zhang, Hai-Tao Su, Yu-Jie Liu, Ning Pang, Ji Li, X. Qi   +5 more
semanticscholar   +1 more source

Trajectory planning and tracking control for towed carrier aircraft system

Aerospace Science and Technology, 2019
As an efficient and safe dispatching scheme is of great importance to ensure the effectiveness and safety of personnel on the Aircraft Carrier, and the towed aircraft system without bar is a common means of dispatching, the dispatching of the system is a
Jie Liu, Wei Han, Haijun Peng, Xinwei Wang   +3 more
semanticscholar   +1 more source

Development of a magnetic nano-graphene oxide carrier for improved glioma-targeted drug delivery and imaging: In vitro and in vivo evaluations.

Chemico-Biological Interactions, 2018
To overcome the obstacles inflicted by the BBB in Glioblastoma multiforme (GBM) we investigated the use of Multifunctional nanoparticles that designed with a Nano-graphene oxide (NGO) sheet functionalized with magnetic poly (lactic-co-glycolic acid ...
Sakine Shirvalilou, S. Khoei, Sepideh Khoee, Nida Jamali Raoufi, M. Karimi, A. Shakeri-Zadeh   +5 more
semanticscholar   +1 more source

Facile preparation of biocompatible nanostructured lipid carrier with ultra-small size as a tumor-penetration delivery system.

Colloids and Surfaces B: Biointerfaces, 2018
Insufficient tumor penetration is one of the major obstacles for satisfactory cancer therapy. As a result, the ability to push the lower limits of size for nanoparticle platforms that have traditionally existed in larger forms is highly desirable. In our
Xin Zhao, D. Tang, Tie Yang, Cheng Wang
semanticscholar   +1 more source

Increasing the anticancer activity of azidothymidine toward the breast cancer via rational design of magnetic drug carrier based on molecular imprinting technology.

Materials Science and Engineering C: Materials for Biological Applications, 2019
Cancer treatment based anticancer drugs face serious obstacles. To prevail these obstacles, an effective targeted drug carrier can be imperative. This study aimed to design rationally an imprinting strategy for the carrying of a model anticancer drug ...
A. Hassanpour, M. Irandoust, Ebrahim Soleimani, H. Zhaleh   +3 more
semanticscholar   +1 more source

Fatty alcohol containing nanostructured lipid carrier (NLC) for progesterone oral delivery: In vitro and ex vivo studies

Journal of Drug Delivery Science and Technology, 2018
This study aims to overcome most of the obstacles that face oral administration of progesterone. Fatty alcohols (cetyl, cetostearyl and 1:1 mixture) containing NLCs were thought to be one of the most relevant systems based on progesterone drawbacks as ...
Mohammed Elmowafy, Khaled Shalaby, Mohamed M. Badran, Mohamed M. Badran, Hazim M Ali, Mohamed Abdelbakky, Ibrahim M. El-Bagory   +6 more
semanticscholar   +1 more source

Thermal‐Adaptive Photonic MOFs for High‐Performance X‐ray Scintillator

Advanced Functional Materials
Dynamic responsive scintillating materials play a significant role in advanced radiation detection technology. However, the issues such as thermal quenching, uncontrollable structure, and unsatisfactory cost, still remain obstacles to the diversified ...
Hong-Jun Li, Qianghui Dong, Yi Li, Enlai Hu, Yujie Cai, Lin Zhang, Dian Zhao, Hai Guo, Guo-Dong Qian   +8 more
semanticscholar   +1 more source

An ATP-activated spatiotemporally controlled hydrogel prodrug system for treating multidrug-resistant bacteria-infected pressure ulcers

Bioactive Materials
Adenosine triphosphate (ATP)-activated prodrug approaches demonstrate potential in antibacterial uses. However, their efficacy frequently faces obstacles due to uncontrolled premature activation and spatiotemporal distribution differences under ...
Xiaoliang Qi, Yajing Xiang, Ying Li, Jiajia Wang, Yu-Xi Chen, Yulong Lan, Jinsong Liu, Jianliang Shen   +7 more
semanticscholar   +1 more source

Blue Perovskite Light‐Emitting Diodes Using Multifunctional Small Molecule Dopants

Advances in Materials
Unbalanced charge carrier injections and high densities of non‐radiative recombination channels are still major obstacles to advancing high‐efficiency blue perovskite light‐emitting diodes (LEDs).
Zema Chu, Wei Zhang, Ji Jiang, Zheng-Chang Xia, Mingming Shi, Biwen Li, Linjie Dai, Yunxiu Shen, Yaowen Li, N. Greenham, Richard H. Friend, Xingwang Zhang, Jing-Bi You   +12 more
semanticscholar   +1 more source

Obstacles affecting innovation in small and medium enterprises: Quantitative analysis of the Argentinean manufacturing sector

Research Policy, 2021
Valeria Arza
exaly