Results 1 to 10 of about 81,322 (215)

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Optimized DSP Framework for 112 Gb/s PM-QPSK Systems with Benchmarking and Complexity–Performance Trade-Off Analysis

Eng
In order to enhance the performance of 112 Gb/s polarization-multiplexed quadrature phase-shift keying (PM-QPSK) coherent optical receivers, a novel digital signal processing (DSP) framework is presented in this study.
Julien Moussa H. Barakat, Abdullah S. Karar, Bilel Neji   +2 more
doaj   +1 more source

Two-Stage n-PSK Partitioning Carrier Phase Recovery Scheme for Circular mQAM Coherent Optical Systems

Photonics, 2016
A novel two-stage n-PSK partitioning carrier phase recovery (CPR) scheme for circular multilevel quadrature amplitude modulation (C-mQAM) constellations is presented.
Jaime Rodrigo Navarro, Aditya Kakkar, Xiaodan Pang, Miguel Iglesias Olmedo, Oskars Ozolins, Francesco Da Ros, Molly Piels, Richard Schatz, Darko Zibar, Gunnar Jacobsen, Sergei Popov   +10 more
doaj   +1 more source

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

Analysis of signal processing techniques for optical 112 Gb/s DP-QPSK receivers with experimental data

Journal of Microwaves, Optoelectronics and Electromagnetic Applications
This paper evaluates several signal processing techniques for optical dual-polarization quadrature phase-shift keying (DP-QPSK) coherent receivers, using offline post-processing of experimental data.
Thiago F. Portela, Diego V. Souto, Valery N. Rozental, Hugo B. Ferreira, Darli A. A. Mello, Helmut Griesser   +5 more
doaj   +1 more source

Laser Phase Noise Effects and Joint Carrier Phase Recovery in Coherent Optical Transmissions With Digital Subcarrier Multiplexing

IEEE Photonics Journal, 2017
In this paper, we numerically and experimentally investigate the impairments related to laser phase noise in coherent digital subcarrier multiplexing (SCM) systems.
Meng Qiu, Qunbi Zhuge, Mathieu Chagnon, Fangyuan Zhang, David V. Plant   +4 more
doaj   +1 more source

Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer

Molecular Oncology, EarlyView.
COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann, Eduardo García‐Galea, Alice O'Farrell, Zak Kinsella, Maxime Meylan, Florent Petitprez, Ingrid Arijs, Tom Venken, Hari Ps, Adrian Lärkeryd, Ian Miller, Janick Selves, Nadja Meindl‐Beinker, Fiorella Ruiz‐Pace, Elena Élez, Raquel Comas‐Navarro, Frank Lincoln, Dirk Fey, Gift Nyamundanda, Aoife Nolan, Joern Lewin, Raquel Perez‐Lopez, Jonathan Briody, Kathleen Bennett, Walter Kolch, David Matallanas, Alexander Kel, Enrique Arenas, Joaquín Arribas, Bart Ghesquière, Josep Tabernero, Julie Meilleroux, Deborah McNamara, Ray McDermott, Marvin Lim, Mary O'Reilly, Brian Bird, Lisa Stack, Lucia Moloney, Patrick Morris, Keith Egan, Maciej Milewski, Lars Scheuer, Joachim Behringer, Georg Bolz, Ramon Salazar, Cristina Santos, Andrea Ruiz, Orla Casey, Verena Murphy, Matthias Ebert, Livio Trusolino, Diether Lambrechts, Anguraj Sadanandam, Catherine Sautès‐Fridman, Jochen Prehn, Paolo Nuciforo, Jacques Fieschi, Florence Monville, Darran O'Connor, Wolf Fridman, Annette Byrne   +61 more
wiley   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

High-speed algorithm for carrier frequency recovery and frame synchronization in QPSK-modulated modems

Tekhnologiya i Konstruirovanie v Elektronnoi Apparature, 2018
When demodulating signals in communication systems with QPSK modulation operating in the pulsed mode, the following problems arise: rapid elimination of the reference oscillator phase ambiguity and ensuring reliable frame synchronization for a given ...
A. V. Sadchenko, O. A. Kushnirenko, E. K. Koshelev, V. I. Bondar   +3 more
doaj   +1 more source