Results 131 to 140 of about 6,901,957 (346)

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Of its five acyl carrier proteins, only AcpP1 functions in Ralstonia solanacearum fatty acid synthesis. [PDF]

Front Microbiol, 2022
Yin Y, Li R, Liang WT, Zhang WB, Hu Z, Ma JC, Wang HH.   +6 more
europepmc   +1 more source

Abstract 1132 High-throughput Virtual Screening of Potential Novel Inhibitors for Enoyl Acyl Protein Carrier Reductase (FabV) in Yersinia pestis [PDF]

Aira Balasubramanian, Arnav Patil, Sarah Sallami, Michelle Jiménez, Halimot Badmus, Kimberly Heineken, Quốc Thái Nguyễn, Josh Beckham   +7 more
openalex   +1 more source

Characterization of β-Ketoacyl-Acyl Carrier Protein Synthase III from Streptomyces glaucescens and Its Role in Initiation of Fatty Acid Biosynthesis [PDF]

, 1998
Lei Han, Sandra Lobo, Kevin A. Reynolds
openalex   +1 more source

Novel protein carrier system based on cyanobacterial nano‐sized extracellular vesicles for application in fish

, 2022
Jorge Matinha‐Cardoso, Filipe Coutinho, Steeve Lima, Ana Eufrásio, António Paulo Carvalho, Aires Oliva‐Teles, José Bessa, Paula Tamagnini, Cláudia R. Serra, Paulo Oliveira   +9 more
openalex   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

T300A GENETIC POLYMORPHISM: a susceptibility factor for Crohn’s disease?

Arquivos de Gastroenterologia
ContextCrohn’s disease is characterized by a chronic and debilitating inflammatory disorder of the gastrointestinal tract. Several factors may contribute to its development.
Bruno Lorenzo SCOLARO, Emily dos SANTOS, Leslie Ecker FERREIRA, Paulo Henrique Condeixa de FRANÇA, Harry KLEINUBING, Paulo Gustavo KOTZE, Mauro de Souza Leite PINHO   +6 more
doaj   +1 more source

Anammox Bacterial S-Adenosyl-l-Methionine Dependent Methyltransferase Crystal Structure and Its Interaction with Acyl Carrier Proteins. [PDF]

Int J Mol Sci, 2023
Uegaki T, Takei T, Yamaguchi S, Fujiyama K, Sato Y, Hino T, Nagano S.   +6 more
europepmc   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

A Clinical Trial of Entolimod a TLR-5 Adjuvant for Vaccines Using Diphtheria or Tetanus as Carrier Proteins. [PDF]

Vaccines (Basel), 2022
Kosten TR, Domingo CB, Haile CN, Nielsen DA.   +3 more
europepmc   +1 more source