Results 151 to 160 of about 8,126,655 (341)

Post-marketing safety surveillance for both CRM197 and TT carrier proteins PCV13 in Jiangsu, China. [PDF]

Front Public Health, 2023
Hu R, Liu Y, Zhang L, Kang G, Xu B, Li M, Yu J, Zhu Y, Guo H, Wang Z.   +9 more
europepmc   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Chemical Modification of Cytochrome C for Acid-Responsive Intracellular Apoptotic Protein Delivery for Cancer Eradication

Pharmaceutics
Delivering bioactive proteins into cells without carriers presents significant challenges in biomedical applications due to limited cell membrane permeability and the need for targeted delivery.
Bo Tang, Kwai Man Lau, Yunxin Zhu, Chihao Shao, Wai-Ting Wong, Larry M. C. Chow, Clarence T. T. Wong   +6 more
doaj   +1 more source

Transport of ADP/ATP carrier into mitochondria [PDF]

, 1984
Precursor to ADP/ATP carrier synthesized in vitro is transferred into isolated mitochondria to a protease-resistant location. This process requires an electrical potential across the inner membrane.
Neupert, Walter, Schleyer, Manfred
core  

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

Molecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns, Jaclyn S. Long, Sergio Lilla, Kelly Hodge, Marcus J. G. W. Ladds, Colin Nixon, Paula Fernández‐Palanca, Sara Zanivan, Pilar Acedo, Stephen P. Pereira, Kevin M. Ryan   +10 more
wiley   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

T300A GENETIC POLYMORPHISM: a susceptibility factor for Crohn’s disease?

Arquivos de Gastroenterologia
ContextCrohn’s disease is characterized by a chronic and debilitating inflammatory disorder of the gastrointestinal tract. Several factors may contribute to its development.
Bruno Lorenzo SCOLARO, Emily dos SANTOS, Leslie Ecker FERREIRA, Paulo Henrique Condeixa de FRANÇA, Harry KLEINUBING, Paulo Gustavo KOTZE, Mauro de Souza Leite PINHO   +6 more
doaj   +1 more source

Evidence for Non-Essential Salt Bridges in the M-Gates of Mitochondrial Carrier Proteins. [PDF]

Int J Mol Sci, 2022
Miniero DV, Monné M, Di Noia MA, Palmieri L, Palmieri F.   +4 more
europepmc   +1 more source

Synthesis and intracellular transport of mitochondrial proteins [PDF]

, 1985
A Lustig, A Lustig, A Ohashi, A Viebrock, AJ Lamb, AP Autor, AS Lewin, AS Lewin, B Hennig, B Schmidt, BE Roberts, BG Barrell, C Cote, C Zwizinski, CJ Leaver, DI Meyer, DI Meyer, DL Stigall, DM Kolansky, E Komar, E Marra, E Pratje, E Schmelzer, G Attardi, G Blobel, G Daum, G Daum, G Hallermayer, G Hallermayer, G Kreibich, G Kreil, G Macino, G Reid, G Schatz, G Schatz, G Schatz, G Srivastava, GC Shore, GC Shore, H Freitag, H Koehler, H Korb, H Riezman, H Weiss, IG Macreadie, IZ Ades, IZ Ades, J Kaput, JG Conboy, JP Kraus, K Mihara, K Mihara, K Mihara, K Watanabe, L Ernster, L Randall, LA Grivell, LE Aziz, M Inouye, M Klingenberg, M Klingenberg, M Maccechini, M Mori, M Mori, M Schleyer, M Suissa, M Teintze, M Wikstrom, M Yamamoto, M-L Maccechini, MA Harmey, MA Harmey, MD Hampsey, MM Mueckler, N Cerletti, N Nabi, N Nelson, NK Bhat, P Boehni, P Boehni, P Boogart van den, P Borst, P Borst, P Borst, P McAda, P Sonderegger, P Walter, PC Heinrich, PC Kreibich, PG Adolphus, R Jaussi, R Michel, R Sakakibara, R Zimmermann, R Zimmermann, R Zimmermann, R Zimmermann, RE Kellems, RE Kellems, RO Poyton, S Matsuura, S Miura, S Passarella, S Werner, SD Emr, SM Gasser, SM Gasser, SM Gasser, T Hunt, T Monta, T Oda, VA Rucker, W Neupert, W Wickner, Y Kamisaki, Y Raymond, Y Sagara, Y Yoshida   +117 more
core   +1 more source