Results 201 to 210 of about 6,901,957 (346)

The impact of solute carrier proteins on disrupting substance regulation in metabolic disorders: insights and clinical applications. [PDF]

Front Pharmacol
Du J, Shen M, Chen J, Yan H, Xu Z, Yang X, Yang B, Luo P, Ding K, Hu Y, He Q.   +10 more
europepmc   +1 more source

Glucose Availability Alters Gene and Protein Expression of Several Newly Classified and Putative Solute Carriers in Mice Cortex Cell Culture and D. melanogaster

, 2020
Mikaela M. Ceder, Emilia Lekholm, Axel Klaesson, Rekha Tripathi, Nadine Schweizer, Lydia Weldai, Sourabh Patil, Robert Fredriksson   +7 more
openalex   +1 more source

Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib

Molecular Oncology, EarlyView.
WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute, Júlia Huguet‐Pradell, Jordi Abril‐Fornaguera, Albert Gris‐Oliver, Alex Rialdi, Elisa Fernández‐Martínez, Carla Montironi, Vanessa Del Pozo, Peter Houghton, Laura Zanatto, Agavni Mesropian, Ieva Keraite, Swan Thung, Carolina Armengol, Pau Sancho‐Bru, Ernesto Guccione, Roser Pinyol, Josep M. Llovet   +17 more
wiley   +1 more source

Elucidating the role of carrier proteins in cytokine stabilization within double emulsion-based polymeric nanoparticles. [PDF]

Bioeng Transl Med
Rhodes ER, Day NB, Aldrich EC, Wyatt Shields C, Sprenger KG.   +4 more
europepmc   +1 more source

Direct acylation of carrier proteins with functionalized beta-lactones.

Organic Letters, 2010
J. Amoroso, Lawrence S. Borketey, Gitanjeli Prasad, N. A. Schnarr   +3 more
semanticscholar   +1 more source

A tagged parathyroid hormone derivative as a carrier of antibody cargoes transported by the G protein coupled PTH1 receptor

, 2014
Xavier Charest‐Morin, Jean‐Philippe Fortin, Robert Lodge, Isabelle Allaeys, Patrice E. Poubelle, François Marceau   +5 more
openalex   +2 more sources

Self and foreign 60-kilodalton heat shock protein T cell epitope peptides serve as immunogenic carriers for a T cell-independent sugar antigen. [PDF]

, 1995
Stephanie Könen‐Waisman, Mati Fridkin, Irun R. Cohen   +2 more
openalex   +1 more source

Design, Synthesis and Biological Investigation of Some Novel Quinazolin-4(3H)-One Tethered 1, 3, 4-Thiadiazole-Thiol Motifs as Direct Enoyl Acyl Carrier Protein Reductase Inhibitors

, 2021
Anant Deshpande, Shashikant C. Dhawale, Sanjay B. Bari, Chandrakant Bonde   +3 more
openalex   +2 more sources

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

Divergent Tandem Acyl Carrier Proteins Necessitate In-Series Polyketide Processing in the Leinamycin Family. [PDF]

Angew Chem Int Ed Engl
Phillips AP, Winter AJ, Hooper CM, Williams C, Crosby J, Willis CL, Crump MP.   +6 more
europepmc   +1 more source