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ALS plasma biomarkers reveal neurofilament and pTau correlate with disease onset and progression
Annals of Clinical and Translational Neurology, EarlyView.Abstract Objective We performed a pilot screen to assess the utility of the NULISA™ (Nucleic‐acid‐Linked Immuno‐Sandwich Assay) platform in the identification of amyotrophic lateral sclerosis (ALS) biomarkers. Methods Plasma from 86 individuals (48 ALS, 18 asymptomatic C9orf72 repeat expansion carriers (AsymC9), and 20 healthy controls) was analyzed ...
Eleanor V. Thomas +10 more
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UDP‐glucose dehydrogenase variants cause dystroglycanopathy
Annals of Clinical and Translational Neurology, EarlyView.Abstract UDP‐glucose dehydrogenase (UGDH) variants have been associated with hypotonia, developmental delay, and epilepsy. We report the first pathologic evidence of dystroglycanopathy in siblings with UGDH variants. Both presented around 6 months with developmental delay and elevated creatinine kinase.
Anna M. Reelfs +8 more
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Biosynthesis and assembly of nuclear-coded mitochondrial membrane proteins in Neurospora crassa [PDF]
, 1983 Neupert, Walter, Zimmermann, Richard
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Transport and Carrier Proteins
2021Apoprotein (Apo) is the major protein component of lipoprotein that determines its properties. Apolipoproteins are generally divided into 5–7 types. Most of their amino acid sequences have been determined. The types of apolipoproteins are named according to the classification system suggested by Alaupovic in 1972. The types are encoded with the English
Zhiwei Li, Changmin Wang
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Antibodies as carrier proteins.
Pharmaceutical research, 1998Pre-existing antibodies against a drug substance can significantly alter the pharmacokinetic profile of the drug in the circulation. Rapid clearance, mediated by complement or Fc receptors, occurs for crosslinked immune complexes, but not for complexes containing only one or two antibodies.
Bruce N. Rehlaender, Moo J. Cho
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CARRIER WEIGHTS OF CONJUGATED PROTEINS
Nature, 1941IT has recently been observed1 that the carrier weights, that is, the weight of protein carrying one gram–equivalent of prosthetic group, of a class of conjugated proteins, the chromoproteins, is in many cases equal to the Svedberg unit of about 17,600 gm. In no case is it appreciably less.
Broda, Engelbert, Goodeve, C. F.
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Import of Carrier Proteins into Mitochondria
Biological Chemistry, 1999AbstractCarrier proteins located in the inner membrane of mitochondria are responsible for the exchange of metabolites between the intermembrane space and the matrix of this organelle. All members of this family are nuclear-encoded and depend on translocation machineries for their import into mitochondria.
Truscott, Kaye N., Pfanner, Nikolaus
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Molecular and Cellular Endocrinology, 1984
The somatomedins, such as the insulin-like growth factors I and II, somatomedins A and C, and multiplication-stimulating activity, are small, growth hormone dependent polypeptides which are the assumed mediators of growth hormone action on extraskeletal tissues.
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The somatomedins, such as the insulin-like growth factors I and II, somatomedins A and C, and multiplication-stimulating activity, are small, growth hormone dependent polypeptides which are the assumed mediators of growth hormone action on extraskeletal tissues.
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Secretory carrier membrane proteins
Protoplasma, 2011Secretory carrier membrane proteins (SCAMPs) are a family of integral membrane proteins that play roles in mediating exocytosis in animal cells. However, relatively little is known about the subcellular localization, trafficking, and function of SCAMPs in plants.
Angus Ho Yin Law +2 more
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Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, 2000
The compartmentalization of cholesterol metabolism implies target-specific cholesterol trafficking between the endoplasmic reticulum, plasma membrane, lysosomes, mitochondria and peroxisomes. One hypothesis has been that sterol carrier protein-2 (SCP2, also known as the non-specific lipid transfer protein) acts in cholesterol transport through the ...
Jerzy Roch Nofer +2 more
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The compartmentalization of cholesterol metabolism implies target-specific cholesterol trafficking between the endoplasmic reticulum, plasma membrane, lysosomes, mitochondria and peroxisomes. One hypothesis has been that sterol carrier protein-2 (SCP2, also known as the non-specific lipid transfer protein) acts in cholesterol transport through the ...
Jerzy Roch Nofer +2 more
openaire +3 more sources