Guiding AlphaFold to predict how Munc13‐1 opens Syntaxin‐1
The syntaxin‐1 Habc‐domain (orange), linker (pink) and SNARE motif (yellow) form a closed conformation that binds to Munc18‐1 (violet) and is opened by the Munc13‐1 MUN domain (cyan) to form the SNARE complex that triggers neurotransmitter release.
Madhurima Chattopadhyay +2 more
wiley +1 more source
The Interplay of Phonons and Subgap States Governs Ultrafast Carrier Dynamics in Layered HgPSe<sub>3</sub>. [PDF]
Baserga A +17 more
europepmc +1 more source
Small RNA pathways in mammalian oocytes
Three distinct small RNA pathways operate in mammalian oocytes: RNAi interference (RNAi), the microRNA (miRNA) pathway, and the PIWI‐associated RNA (piRNA) pathway. These pathways use small RNAs to guide sequence‐specific repression and contribute to oocyte biology by targeting genes and mobile elements or appear insignificant since different ...
Petr Svoboda, Josef Pasulka
wiley +1 more source
Oxygen-vacancy-induced half-metallicity and enhanced ferromagnetism in Sr<sub>2</sub>NiMnO<sub>6</sub>: a DFT and Monte Carlo approach. [PDF]
Apu RS +4 more
europepmc +1 more source
Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard +12 more
wiley +1 more source
Packing, Flow and Aerosolization Properties of Binary Adhesive Mixtures Containing Micronized and Spray-Dried Drugs. [PDF]
Simonsson A +4 more
europepmc +1 more source
Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells
Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim +4 more
wiley +1 more source
A Conditional Structural Organization of the Light-Baryon Spectrum: Eighteen Channels and Nucleon Mass Ratios. [PDF]
Li B.
europepmc +1 more source
Correction: Liu et al. Research on Monocrystalline Silicon Micro-Nano Structures Irradiated by Femtosecond Laser. <i>Materials</i> 2022, <i>15</i>, 4897. [PDF]
Liu Y +6 more
europepmc +1 more source
Resonant Doping in Binary Sb(V)-Oxide Sb<sub>2</sub>O<sub>5</sub> for High-Mobility Transparent Conductors. [PDF]
Li K, Claes R, Squires AG, Scanlon DO.
europepmc +1 more source

