Results 81 to 90 of about 441,417 (303)

Variations and inconsistencies in venous ablation coverage policies between single-state and multistate carriers in the United States [PDF]

open access: hybrid, 2023
Paula Pinto Rodríguez   +8 more
openalex   +1 more source

Diversity and complexity in neural organoids

open access: yesFEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

open access: yesFEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil   +4 more
wiley   +1 more source

Infección respiratoria aguda en niños que acuden a un centro de desarrollo infantil Incidence of acute respiratory infections in a cohort of infants and children attending a daycare center in Mexico City

open access: yesSalud Pública de México, 2002
Objetivo. Establecer la incidencia de infección respiratoria y los patrones de colonización faríngea en niños que asisten a guarderías. Material y métodos.
Eugenia Nandí-Lozano   +3 more
doaj  

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

open access: yesFEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Rab14 regulates the transport of human papillomavirus to the trans‐Golgi network for infectious cell entry

open access: yesFEBS Letters, EarlyView.
This study reveals that the small GTPase Rab14 is necessary for human papillomavirus (HPV) infection and plays an essential role in the transport of virions to the trans‐Golgi network (TGN). HPV in the early endosome (EE), which harbors GTP‐bound Rab14, is transported to the TGN through the switch of Rab14 from its GTP‐bound to GDP‐bound form.
Yoshiyuki Ishii, Iwao Kukimoto
wiley   +1 more source

Ocorrência de Campylobater spp entre manipuladores de alimentos em cozinhas hospitalares de localidade urbana da região Sul do Brasil

open access: yesRevista de Saúde Pública
Pesquisa realizada em cozinhas hospitalares e institucionais do Município de Florianópolis, SC (Brasil) sobre a presença de Campylobacter em fezes de manipuladores de alimentos, demonstrou que a média de portadores foi de 6,2%.
Iraci Tosin, Ruben Abreu Machado
doaj  

The blood count as a compass to navigate in the ever-changing landscape of the carrier state of hemoglobinopathies: a single-center Italian experience. [PDF]

open access: yesFront Pediatr, 2023
Marchesani S   +8 more
europepmc   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

open access: yesFEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto   +3 more
wiley   +1 more source

The association between a carrier state of FMR1 premutation and numeric sex chromosome variations. [PDF]

open access: yesJ Assist Reprod Genet, 2023
Malcov M   +7 more
europepmc   +1 more source

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