Results 21 to 30 of about 263,843 (312)

Research on the Development Path of Urban Rail Transit Traction Power Supply System Based on Foreign Experience

Chengshi guidao jiaotong yanjiu
［Objective］ In the context of the current urban rail transit towards intelligent，green and low-carbon development, upgrading the traction power supply system, the "heart" of urban rail transit, is of crucial importance for realizing the green and smart ...
HU Ji, LING Chen, SU Jingqi, LIU Shuo
doaj   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

The Driver-Car [PDF]

Theory, Culture & Society, 2004
The car has become ubiquitous in late modern society and has become the leading object in the ordinary social relations of mobility. Despite its centrality to the culture and material form of modern societies, the relationship between the car and human beings has remained largely unexplored by sociology. This article argues that cars are combined with
openaire   +2 more sources

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

Molecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix, Daniel Samaga, Katharina Gehr, Benedek Dankó, Mohamed Schumann, Guido Drexler, Ahmed Alnatsha, Georg Beyer, Ujjwal Mahajan, Martin Selmansberger, Julia Mayerle, Claus Belka, Horst Zitzelsberger, Kirsten Lauber   +13 more
wiley   +1 more source

Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition

Molecular Oncology, EarlyView.
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li, Shuichi Tatarano, Hirofumi Yoshino, Saeki Saito, Mitsuhiko Tominaga, Junya Arima, Ikumi Fukuda, Takashi Sakaguchi, Ryosuke Matsushita, Yasutoshi Yamada, Hideki Enokida   +10 more
wiley   +1 more source

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

Adaptive Determination of Optimum Switching Frequency in SiC-PWM-Based Motor Drives: A Speed-Dependent Core Loss Correction Approach

IEEE Open Journal of the Industrial Electronics Society
This study focuses on identifying the optimal switching frequency for silicon-carbide (SiC)-based motor drives across a wide range of operating conditions using a loss minimization strategy. The results are then compared with those of traditional silicon-
Sepideh Amirpour, Sima Soltanipour, Torbjorn Thiringer, Pranav Katta   +3 more
doaj   +1 more source

Seasonal variations of microbes in particulate matter obtained from Dhaka City in Bangladesh

Environmental Pollutants & Bioavailability, 2021
The present study, for the first time, evaluated the seasonal variation of PM10-associated bacterial and fungal concentrations at four locations (CARS premises, Doyel Chattar, Postogola, and Chittagong Road) in Dhaka, Bangladesh.
Jahan-E- Gulshan, Shahid Akhtar Hossain, Mohammad Enayet Hossain, Md Mominul Islam, Sharmin Zaman Emon, Amika Ahmed Manzum, Zuairia Binte Jashim, Muhammad Nurul Huda   +7 more
doaj   +1 more source

Cotargeting TREM2 and IL2 pathways triggers multipronged anticancer immunity

Molecular Oncology, EarlyView.
Von Locquenghien et al. report that MiTE‐144, a triggering receptor expressed on myeloid cells 2 (TREM2) blocking antibody fused to interleukin‐2 (IL2) variant with tumour microenvironment restricted activation, demonstrates superior anticancer efficiency in a preclinical setting.
Isaure Vanmeerbeek, Jenny Sprooten, Abhishek D. Garg   +2 more
wiley   +1 more source

MODIFIED METHOD AND DESIGN OF A POWER BRAKE STAND FOR VEHICLE TESTING

International Journal of Advanced Studies, 2022
The principles of functioning of stands for testing the braking qualities of wheeled vehicles are considered. Their advantages and disadvantages are analyzed.
Igor M. Blyankinstein, Pavel M. Tarasov
doaj   +1 more source