Results 41 to 50 of about 241,740 (317)

MODIFIED METHOD AND DESIGN OF A POWER BRAKE STAND FOR VEHICLE TESTING

open access: yesInternational Journal of Advanced Studies, 2022
The principles of functioning of stands for testing the braking qualities of wheeled vehicles are considered. Their advantages and disadvantages are analyzed.
Igor M. Blyankinstein, Pavel M. Tarasov
doaj   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

open access: yesMolecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric   +10 more
wiley   +1 more source

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

open access: yesMolecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera   +11 more
wiley   +1 more source

The Close AGN Reference Survey (CARS)

open access: yes, 2017
The role of active galactic nuclei (AGN) in the evolution of galaxies remains a mystery. The energy released by these accreting supermassive black holes can vastly exceed the entire binding energy of their host galaxies, yet it remains unclear how this ...
McElroy, Rebecca   +17 more
core   +1 more source

Ingrained habits: the “kitchen cars” and the transformation of postwar Japanese diet and identity [PDF]

open access: yes, 2020
This article explores the history and politics of American-funded food demonstration buses (“kitchen cars”) in postwar Japan. Their express mission was to transform the Japanese national diet. I make two primary arguments. First, at least in the short to
Hopson, Nathan
core   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

open access: yesMolecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary   +1 more
wiley   +1 more source

[News Clip: Cars]

open access: yes, 1960
Video footage from the WBAP-TV television station in Fort Worth, Texas, to accompany a news story about the Tarrant County Modified Auto Association's annual car display at the Will Rogers Exhibits Building.
WBAP-TV (Television station : Fort Worth, Tex.)
core   +1 more source

Study on the influence of belt angle on tire grounding characteristics under longitudinal slip conditions

open access: yesJournal of Engineered Fibers and Fabrics
Using ABAQUS software as a tool and 225/60R18 tire as the research object, a finite element model of the tire was established and longitudinal slip simulation was conducted based on the completion of longitudinal slip and rubber material tests.
Jun-Ling Meng   +5 more
doaj   +1 more source

Expanding the frontier of CAR therapy: comparative insights into CAR-T, CAR-NK, CAR-M, and CAR-DC approaches

open access: yesAnnals of Hematology
Chimeric antigen receptor (CAR) therapies have demonstrated remarkable clinical efficacy in hematological malignancies, validating their therapeutic potential. However, challenges such as therapeutic resistance and limited accessibility hinder their broader application.
Zhang, Yiling   +3 more
openaire   +2 more sources

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

open access: yesMolecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim   +3 more
wiley   +1 more source

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