Results 51 to 60 of about 241,740 (317)

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

AI-Assisted Multi-Physics Evaluation of Mission Profile-Based Traction Inverter Design for Sustainability

World Electric Vehicle Journal
As the global transition toward carbon neutrality accelerates, the sustainability of power electronics has received growing attention from both academia and industry.
Chi Zhang, Riccardo Negri
doaj   +1 more source

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source

Light‐Driven, Dynamic Assembly of Micron‐To‐Centimeter Parts, Micromachines and Microbot Swarms

Advanced Science
This work describes light‐driven assembly of dynamic formations and functional particle swarms controlled by appropriately programmed light patterns. The system capitalizes on the use of a fluidic bed whose low thermal conductivity assures that light ...
Konstantin Polev, Govind Paneru, Valentin Visyn, Olgierd Cybulski, Slawomir Lach, Diana V. Kolygina, Evelyn Edel, Bartosz A. Grzybowski   +7 more
doaj   +1 more source

Identification of functional murine mitochondrial formyl peptides and their effects on myeloid‐derived suppressor cell generation

FEBS Open Bio, EarlyView.
We first identified functional murine mitochondrial N‐formyl peptides (MT‐FPs) and investigated their effects on the in vitro myeloid‐derived suppressor cell (MDSC) generation from bone marrow cells. We demonstrated that MT‐FPs acted directly on bone marrow cells to promote MDSC generation and modulated the polymorphonuclear (PMN)‐MDSC/monocyte (M ...
Miyako Ozawa, Saori Kagoshima, Akira Yamada   +2 more
wiley   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source

Accelerated Introduction of ‘Clean’ Cars in Sweden

, 2011
The increased focus in Sweden on greenhouse gas emissions, oil dependency and energy efficiency has lead to the implementation of different policy measures in the transport sector.
Staffan Algers, Muriel Beser Hugosson, Beser Hugosson, Muriel,, Algers, Staffan,   +3 more
core   +1 more source

The Quantum Car [PDF]

IEEE Wireless Communications Letters, 2016
4 pages, 1 ...
openaire   +3 more sources

Proteasomal degradation of intracellularly expressed Amblyomin‐X limits suicide gene therapy potential in melanoma cells

FEBS Open Bio, EarlyView.
This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel, Carlos DeOcesano Pereira, Aline Ramos Maia Lobba, Melissa Regina Fessel, Ana Marisa Chudzinski‐Tavassi   +4 more
wiley   +1 more source

Design and operation of a femtosecond micro-CARS experimental apparatus [PDF]

, 2021
La spettroscopia Raman consente di misurare mappe vibrazionali di campioni con alta risoluzione spaziale, utili per l’identificazione di composti chimici senza l’utilizzo di marcatori.
Ghezelbash, M., Merla, C., Marrocco, M., Rondino, F., Falconieri, M., Gagliardi, S.   +5 more
core